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                                 UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                    FORM 144

                     NOTICE OF PROPOSED SALE OF SECURITIES
              PURSUANT TO RULE 144 UNDER THE SECURITIES ACT OF 1933

ATTENTION: TRANSMIT FOR FILING 3 COPIES OF THIS FORM CONCURRENTLY WITH EITHER
           PLACING AN ORDER WITH A BROKER TO EXECUTE A SALE OR EXECUTING A SALE
           DIRECTLY WITH A MARKET MAKER.



                                                                                                            
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 1(a) NAME OF ISSUER (Please type or print)                  (b) IRS IDENT. NO.       (c) S.E.C. FILE NO.
      Pro-Pharmaceuticals, Inc.                                  04-3562325

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  (d) ADDRESS OF ISSUER                   STREET           CITY           STATE           ZIP CODE             (e) TELEPHONE NO.
                                                                                                            ------------------------
                                         7 Wells Ave.       Newton  MA              02459                    Area Code      Number
                                                                                                                   (617) 559-0033
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 2(a) NAME OF PERSON FOR WHOSE ACCOUNT THE   (b) I.R.S. NO.    (c) RELATIONSHIP      (d) ADDRESS  STREET    CITY  STATE  ZIP CODE
      SECURITIES ARE TO BE SOLD                                    TO ISSUER
Bristol Investment Fund, Ltd.                   98-0335509        Shareholder     Caledonian Fund Services Limited, 69 Dr. Roy's Dr.
                                                                                      George Town, Grand Cayman, Cayman Islands
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INSTRUCTION: The person filing this notice should contact the issuer to obtain the I.R.S. Identification Number
             and the SEC File Number
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                        Name and Address of        SEC USE
Title of the Class      Each Broker Through         ONLY
 of Securities To    whom the Securities Are      ---------   Number of Shares or    Aggregate Market
Be Sold (See instr.   To Be Offered or Each        Broker-     Other Units To Be          Value
     3(a))             Market Maker who is         Dealer            Sold            (See instr. 3(d))
                     Acquiring the Securities       File       (See instr. 3(c))
                        (See instr. 3(b))          Number
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Common Stock      Citigroup Prime Broker
                  390 Greenwich Street, 3rd Floor                      39,596             $45,931
                  New York, NY 10013
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 Number of
 Shares or        Approximate Date of        Name of Each Securities
Other Units              Sale                       Exchange
Outstanding         (See instr. 3(f))           (See instr. 3(g))
(See instr.          (MO. DAY  YR.)
   3(e))
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29,751,208              3/5/07                       AMEX
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INSTRUCTIONS:
   1.  (a) Name of issuer.
       (b) Issuer's IRS Identification Number.
       (c) Issuer's SEC file number, if any.
       (d) Issuer's address, including zip code.
       (e) Issuer's telephone number, including area code.

   2.  (a) Name of person for whose account the securities are to be sold.
       (b) Such person's or I.R.S. Identification number, if such a person is an entity.
       (c) Such person's relationship to the issuer (e.g., officer, director, 10 percent stockholder,
           or member of immediate family of any of the foregoing).
       (d) Such person's address, including zip code.

   3.  (a) Title of the class of securities to be sold
       (b) Name and address of each broker through whom the securities are intended to be sold.
       (c) Number of shares or other units to be sold (if debt securities, give the aggregate face amount).
       (d) Aggregate market value of the securities to be sold as of a specified date within 10 days prior
           to the filing of this notice.
       (e) Number of shares or other units of the class outstanding, or if debt securities the face amount
           thereof outstanding, as shown by the most recent report or statement published by the issuer.
       (f) Approximate date on which the securities are to be sold.
       (g) Name of each securities exchange, if any, on which the securities are intended to be sold.

   2


                         TABLE I--SECURITIES TO BE SOLD

Furnish the following information with respect to the acquisition of the
securities to be sold and with respect to the payment of all or any part of the
purchase price or other consideration therefor:

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     Title of    Date You    Nature of Acquisition    Name of Person From        Amount of         Date of      Nature of Payment
    the Class    Acquired       Transaction             Whom Acquired            Securities        Payment
                                                      (If Gift, Also Give        Acquired
                                                      Date Donor Acquired)
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Common Stock      2/14/06       Convertible Note              Issuer                39,596           2/14/06       Cash

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INSTRUCTIONS:
 1. If the securities were purchased and full payment therefore was not made in
    cash at the time of purchase, explain in the table or in a note thereto the
    nature of the consideration given. If the consideration consisted of any
    note or other obligation, or if payment was made in installments describe
    the arrangement and state when the note or other obligation was discharged
    in full or the last installment paid.
 2. If within two years after the acquisition of the securities the person for
    whose account they are to be sold had any short positions, put or other
    option to dispose of securities referred to in paragraph (d)(3) of Rule 144,
    furnish full information with respect thereto.
====================================================================================================================================

             TABLE II--SECURITIES SOLD DURING THE PAST THREE MONTHS

Furnish The Following Information as to All Securities of The Issuer Sold During
 The Past Three Months By The Person For Whose Account The Securities Are To Be
                                     Sold.

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   Name and Address of Seller             Title of Securities Sold         Date of Sale         Amount of        Gross Proceeds
                                                                                               Securities
                                                                                                  Sold
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REMARKS:

INSTRUCTIONS:
 See the definition of "person" in paragraph (a) of Rule 144. Information is to
 be given not only as to the person for whose account the securities are to be
 sold but also as to all other persons included in that definition. In addition,
 information shall be given as to sales by all persons whose sales are required
 by paragraph (e) of Rule 144 to be aggregated with sales for the account of the
 person filing this notice.
                                March 5, 2007
                    ----------------------------------------
                                (DATE OF NOTICE)
ATTENTION:
 The person for whose account the securities to which this notice relates are to
 be sold hereby represents by signing this notice that he does not know any
 material adverse information in regard to the current and prospective
 operations of the issuer of the securities to be sold which has not been
 publicly disclosed.
                                   Paul Kessler
                    ----------------------------------------
                                  (SIGNATURE)

 The notice shall be signed by the persons for whose account the securities are
                         to be sold. At least one copy
  of the notice shall be manually signed. Any copies not manually signed shall
                       bear typed or printed signatures.

 ATTENTION: INTERNATIONAL MISSTATEMENTS OR OMISSION OF FACTS CONSTITUTE FEDERAL
                   CRIMINAL VIOLATIONS (SEE 18 U.S.C. 1001).