Neose Technologies, Inc.

                                     [LOGO]

                                 102 Witmer Road
                           Horsham, Pennsylvania 19044




April 7, 2003

Dear Stockholder:

         You are invited to attend the Annual Meeting of Stockholders of Neose
Technologies, Inc. on May 13, 2003. You will have the opportunity to ask
questions and make comments at the meeting. Enclosed with this letter are your
Notice of Annual Meeting of Stockholders, Proxy Statement, Proxy voting card,
and 2002 Annual Report to Stockholders.

         At this year's meeting, you will be asked to elect nine directors to
serve a term of one year each, to ratify the appointment of our independent
auditors for fiscal 2003, to increase the number of shares issuable under our
Amended and Restated 1995 Stock Option/Stock Issuance Plan, and to increase the
number of shares issuable under our Employee Stock Purchase Plan.

         I hope that you attend the meeting. Whether or not you plan to be with
us, please sign, date, and return your voting card promptly in the enclosed
envelope.

Sincerely,




C. Boyd Clarke
President and Chief Executive Officer



                            Neose Technologies, Inc.

                                     [LOGO]

                                 102 Witmer Road
                           Horsham, Pennsylvania 19044

                    Notice of Annual Meeting of Stockholders
                             to be held May 13, 2003

To the Stockholders of Neose Technologies, Inc.:

         The 2003 Annual Meeting of Stockholders will be held at our offices at
102 Witmer Road, Horsham, Pennsylvania on Tuesday, May 13, 2003 at 9:00 a.m.
During the Annual Meeting, stockholders will be asked to:

1.       Elect nine directors to serve for a term of one year or until the
         election and qualification of their successors;

2.       Ratify the appointment of our independent auditors for fiscal 2003;

3.       Approve an amendment to our Amended and Restated 1995 Stock
         Option/Stock Issuance Plan to increase the number of shares issuable
         under the plan by 825,000 (which represents 4.8% of the shares
         outstanding as of March 21, 2003);

4.       Approve an amendment to our Employee Stock Purchase Plan to increase
         the number of shares issuable under the plan by 33,000; and

5.       Transact any other business properly brought before the Annual Meeting.

         If you are a stockholder as of March 21, 2003, you may vote at the
meeting. The date of mailing this Notice of Meeting and Proxy Statement is on or
about April 7, 2003.

By order of the Board of Directors


Debra J. Poul
Secretary



                                 Proxy Statement

     This Proxy Statement and the accompanying proxy card are being mailed,
beginning on or about April 7, 2003, to owners of shares of common stock of
Neose Technologies, Inc. in connection with the solicitation of proxies by the
Board of Directors for our Annual Meeting of Stockholders. This proxy procedure
is necessary to permit all stockholders, many of whom are unable to attend the
Annual Meeting, to vote. The Board of Directors encourages you to read this
document thoroughly and to take this opportunity to vote on the matters to be
decided at the Annual Meeting.

                                    Contents


                                                                                        
     About the Meeting:  Questions and Answers ........................................      2

     Governance of the Company ........................................................      5
        Independence of Directors .....................................................      5
        Committees of the Board of Directors ..........................................      5
        Compensation of Directors .....................................................      7
        Continuing Education of Directors .............................................      7
        Code of Conduct ...............................................................      8
        Copies of Referenced Documents ................................................      8

     Relationship with Independent Auditors ...........................................      8
        Audit Fees ....................................................................      8
        All Other Fees ................................................................      8

     Report of the Audit Committee ....................................................     10

     Stock Ownership of our Directors, Executive Officers and 5% Beneficial Owners ....     11

     Section 16(a) Beneficial Ownership Reporting Compliance ..........................     14

     Proposal 1 --Election of Directors ...............................................     14
        Nominees for Election .........................................................     14
        Executive Compensation ........................................................     17
        Summary Compensation Table ....................................................     17
        Employment Agreements .........................................................     18
        Change of Control Agreements ..................................................     19
        Separation and Consulting Agreement ...........................................     19
        Option Grants During 2002 .....................................................     20
        Option Exercises and Values for 2002 ..........................................     20
        Report of the Compensation Committee ..........................................     21
        Certain Relationships and Related Transaction .................................     23
        Common Stock Performance Graph ................................................     24

     Proposal 2-- Ratification of Appointment of Independent Auditors .................     24

     Proposal 3 -- Amendment to our Amended and Restated 1995 Stock Option/
        Stock Issuance Plan ...........................................................     25
        Equity Compensation Plan Information ..........................................     31

     Proposal 4-- Amendment to our Employee Stock Purchase Plan .......................     32

     Requirements for Advance Notification of Nominees and Stockholder Proposals ......     36



                    About the Meeting: Questions and Answers

What am I voting on?

1.   The election of nine directors for a one-year term or until the election
     and qualification of their successors.
2.   The ratification of the appointment of KPMG LLP, certified public
     accountants, as independent auditors to audit and report on our financial
     statements for fiscal 2003.
3.   An amendment to our Amended and Restated 1995 Stock Option/Stock Issuance
     Plan to increase by 825,000 shares the number of shares issuable under the
     plan (which represents 4.8% of the shares outstanding as of March 21,
     2003).
4.   An amendment to our Employee Stock Purchase Plan to increase by 33,000
     shares the number of shares issuable under the plan.
5.   Any other business that properly comes before the meeting for a vote.

Who is entitled to vote at the Annual Meeting, and how many votes do they have?

Common stockholders of record at the close of business on March 21, 2003 may
vote at the Annual Meeting. Each share has one vote. There were 17,207,766
shares of common stock outstanding on March 21, 2003. From May 3, 2003 through
May 13, 2003, you may inspect a list of stockholders eligible to vote. If you
would like to inspect the list, please call Debra J. Poul, our Corporate
Secretary, at (215) 315-9000 to arrange a visit to our offices.

How do I vote?

You must be present, or represented by proxy, at the Annual Meeting in order to
vote your shares. Because many of our stockholders are unable to attend the
Annual Meeting in person, we send proxy cards to all of our stockholders to
enable them to be represented and to vote at the Annual Meeting.

What is a proxy?

A proxy is a person you appoint to vote on your behalf. If you are unable to
attend the Annual Meeting, we are seeking your appointment of proxies so that
your shares of common stock may be voted. You must complete and return the
enclosed proxy card to have your shares voted by proxy.

By completing and returning this proxy card, who am I designating as my proxy?

You will be designating C. Boyd Clarke, our President and Chief Executive
Officer, Robert I. Kriebel, our Senior Vice President and Chief Financial
Officer, and A. Brian Davis, our Vice President, Finance, as your proxies. They
may act together or individually on your behalf, and will have the authority to
appoint a substitute to act as proxy.

How will my proxy vote my shares?

Your proxy will vote according to the instructions on your proxy card. If you
complete and return your proxy card but do not indicate your vote, your proxy
will vote "FOR" the election of the nominated slate of directors (see Proposal
1) and "FOR" Proposals 2, 3, and 4. We do not intend to bring any other matter
for a vote at the Annual Meeting, and we do not know of anyone else who intends
to do so. Your proxies are authorized to vote on your behalf, however, using
their best judgment, on any other business that properly comes before the Annual
Meeting.

                                        2



How do I vote using my proxy card?

If you do not plan to vote in person at the Annual Meeting, you may vote by mail
by returning the enclosed proxy card to us. To vote by mail, simply mark, sign,
and date the enclosed proxy card, and return it in the enclosed postage-paid
envelope. Alternatively, you may deliver your proxy card to us in person, by
facsimile, or by a courier.

How do I revoke my proxy?

You may revoke your proxy at any time before your shares are voted at the Annual
Meeting by:

   .   Notifying our Corporate Secretary, Debra J. Poul, in writing at 102
       Witmer Road, Horsham, PA 19044, that you are revoking your proxy;
   .   Executing a new proxy card; or
   .   Attending and voting by ballot at the Annual Meeting.

Is my vote confidential?

Yes, only certain employees will have access to your proxy card. All comments
remain confidential, unless you ask that your name be disclosed.

Who will count the votes?

An officer of Neose Technologies, Inc. will act as the inspector of election and
count the votes.

What constitutes a quorum?

A majority of the 17,207,766 shares outstanding as of the record date, either
present or represented by proxy, constitutes a quorum. A quorum is necessary in
order to conduct the Annual Meeting. If you choose to have your shares
represented by proxy at the Annual Meeting, you will be considered part of the
quorum. If a quorum is not present at the Annual Meeting, the stockholders
present in person or by proxy may adjourn the meeting to a date when a quorum is
present. If an adjournment is for more than 30 days or a new record date is
fixed for the adjourned meeting, we will provide notice of the adjourned meeting
to each stockholder of record entitled to vote at the meeting.

What vote is required to approve each proposal?

Election of Directors. For Proposal 1, the election of directors, the nominees
will be elected by plurality of the votes cast at the Annual Meeting. You may
choose to vote, or withhold your vote, separately for each nominee. A properly
executed proxy marked "WITHHOLD AUTHORITY" with respect to the election of one
or more directors will not be voted with respect to the director or directors
indicated, although it will be counted for the purposes of determining whether
there is a quorum.

Other Proposals. For each other proposal, the affirmative vote of the holders of
a majority of the shares present in person or by proxy and entitled to vote on
the matter will be required for approval. A properly executed proxy marked
"ABSTAIN" with respect to any such matter will not be voted, although it will be
counted for purposes of determining whether there is a quorum. Therefore, an
abstention will have the effect of a negative vote.

If you hold your shares in "street name" through a broker or other nominee, your
broker or nominee may not be permitted to exercise voting discretion with
respect to some of the matters to be acted on. Thus, if you do not give your
broker specific instructions, your shares may not be voted on those matters
(so-called "broker non votes") and will not be counted in determining the number
of shares necessary for approval. As a result,

                                        3



broker non-votes have no effect on the outcome of the vote on a matter, although
the shares represented by "broker non-votes" will be counted in determining
whether there is a quorum.

What percentage of our common shares do the directors and officers own?

As of March 14, 2003, our current directors and executive officers beneficially
owned approximately 19.1% of our common shares. See the discussion under the
heading "Stock Ownership of our Directors, Executive Officers, and 5% Beneficial
Owners" on page 11 for more details.

Who is soliciting my proxy, how is it being solicited, and who pays the cost?

Neose Technologies, Inc., on behalf of the Board of Directors, through its
directors, officers, and employees, is soliciting proxies primarily by mail. In
addition, proxies may also be solicited in person, by telephone, or facsimile.
Morrow & Co., Inc., a proxy solicitation firm, will be assisting us for a fee of
approximately $6,500, plus out-of-pocket expenses. We will pay the cost of
soliciting proxies. We will also reimburse stockbrokers and other custodians,
nominees, and fiduciaries for their reasonable out-of-pocket expenses for
forwarding proxy and solicitation material to the owners of our common shares.

When are stockholder proposals for next year's Annual Meeting due?

To be included in the mailing of the Notice of Annual Meeting of Stockholders,
Proxy Statement, and Proxy voting card for next year's annual meeting, proposed
stockholder proposals must be received between November 10, 2003 and December 9,
2003 by our Corporate Secretary, at 102 Witmer Road, Horsham, PA 19044. You
should submit any proposal by a method that permits you to prove the date of
delivery to us. See the discussion under the heading "Requirements for Advance
Notification of Nominations and Stockholder Proposals" beginning on page 36 for
information regarding certain procedures provided by our By-Laws with respect to
stockholder proposals and nominations of directors.

Who are Neose's independent auditors, and will they be represented at the Annual
Meeting?

KMPG LLP served as the independent accounting firm auditing our financial
statements for 2002, and has been appointed to audit and report on our financial
statements for 2003. We expect a representative of KPMG LLP to be present at the
Annual Meeting. The representative will have an opportunity to make a statement,
if he or she desires, and will be available to answer appropriate questions.

How may I obtain a copy of Neose's Form 10-K?

You may request a copy of our Annual Report on Form 10-K for the year ended
December 31, 2002, by writing to our Corporate Secretary at 102 Witmer Road,
Horsham, Pennsylvania, 19044 or via e-mail at info@neose.com.

                                        4



                            Governance of the Company

     Our business, property and affairs are managed by, or under the direction
of, our Board of Directors, in accordance with the General Corporation Law of
the State of Delaware and our By-laws. Members of the Board of Directors are
kept informed of the Company's business through discussions with the President
and Chief Executive Officer and key members of management, by reviewing
materials provided to them by management, and by participating in meetings of
the Board of Directors and its Committees.

     Our founder, Dr. Roth has served as Chairman of the Board of Directors
since 1994. Our President and Chief Executive Officer, Mr. Clarke, has been
appointed to assume the responsibilities of Chairman of our Board of Directors,
in addition to his other responsibilities, beginning on May 13, 2003. Prior to
appointing Mr. Clarke as Chairman, the Corporate Governance Committee considered
whether the positions of Chairman and Chief Executive Officer should be held by
different people. The Committee concluded that it was appropriate at this stage
of the Company's development to have Mr. Clarke hold both of these positions,
while recognizing the need to reevaluate this decision over time. As noted
below, the Chairman of the Corporate Governance Committee performs several
important independent functions relating to the governance of the Company.

     During 2002, the Board of Directors held nine meetings and the Committees
held a total of 15 meetings. The average attendance of Board members at meetings
of the Board of Directors and Committees on which they served was 93%.

     We have been reviewing our corporate governance policies and practices by
comparing our policies and practices with those suggested by various groups or
authorities active in evaluating or setting best practices for corporate
governance of public companies. Based on this review, we have adopted, and will
continue to adopt, changes that the Board of Directors believes are the best
corporate governance policies and practices for the Company. We have adopted
changes and will continue to adopt changes, as appropriate, to comply with the
Sarbanes-Oxley Act of 2002 and rule changes made by the Securities and Exchange
Commission and NASDAQ.

Independence of Directors

     In December 2002, the Board of Directors adopted a set of Corporate
Governance Principles, addressing, among other things, standards for evaluating
the independence of the Company's directors. The full text of these Principles
can be found on our website at www.neose.com (under the section entitled "About
Neose").

     According to these Principles, no director is considered "independent"
unless the Board has affirmatively determined that the director has no material
relationship with the Company (either directly, or as a partner, stockholder or
officer of an organization that has such a relationship with the Company).
Pursuant to the Principles, the Board undertook its annual review of director
independence in December 2002. After considering all relevant facts and
circumstances, the Board affirmatively determined that all of the directors
nominated for election at the Annual Meeting are independent of the Company
under the standards set forth in the Corporate Governance Principles, with the
exception of Mr. Clarke and Dr. Roth. The Board also determined that Mr. Neff,
who is retiring from the Board, did not meet the standards of independence set
forth in the Principles.

Committees of the Board of Directors

     The Board of Directors has four Committees: the Audit Committee, the
Compensation Committee, the Corporate Governance Committee, and the Scientific
Review Committee. Lowell E. Sears (Chairman), William F. Hamilton, Ph.D. and
Mark H. Rachesky, M.D. are the current members of the Audit Committee.

                                        5



Douglas J. MacMaster, Jr. (Chairman), L. Patrick Gage, Ph.D., and Elizabeth H.
S. Wyatt are the current members of the Compensation Committee. William F.
Hamilton, Ph.D. (Chairman), Douglas J. MacMaster, Jr., Lowell E. Sears, and
Elizabeth H. S. Wyatt are the current members of the Corporate Governance
Committee. L. Patrick Gage, Ph.D. (Chairman) and Stephen A. Roth, Ph.D. are the
current members of the Scientific Review Committee.

     All members of the Audit, Compensation and Corporate Governance Committees
are required to be "independent" as that term is defined in the Corporate
Governance Principles adopted by the Board of Directors in December 2002.

     Audit Committee

     The Audit Committee consists of three directors, all of whom are
"independent" as defined in our Corporate Governance Principles and under the
rules of the Securities and Exchange Commission and NASDAQ. In addition, at
least one member of the Audit Committee qualifies as an "audit committee
financial expert" as defined in SEC Release No. 33-8177 (January 23, 2003). The
Audit Committee operates pursuant to a charter, which is attached as Appendix A
to this Proxy Statement and which can be viewed on our website at www.neose.com
(under "About Neose"). The Report of the Audit Committee is set forth on page 10
of this Proxy Statement.

     Compensation Committee

     The Compensation Committee consists of three non-employee directors, all of
whom are "independent," as defined in our Corporate Governance Principles, and
are also "Non-Employee Directors" as defined in SEC Rule 16(b)-3 and "Outside
Directors" as defined under the treasury regulations promulgated under Section
162(m) of the Internal Revenue Code. The Compensation Committee determines the
compensation of the Chief Executive Officer, and reviews and takes action on the
recommendation of the Chief Executive Officer as to the appropriate compensation
of other officers. The Compensation Committee is primarily responsible for the
administration of our Amended and Restated 1995 Stock Option/Stock Issuance
Plan, under which option grants and stock issuances may be made to all
employees, including executive officers, as well as non-employee directors and
consultants. There are no compensation committee interlocks between our Company
and any other entity involving our Company's or such other entity's executive
officers or board members. The Report of the Compensation Committee is set forth
on page 21 of this Proxy Statement.

     Corporate Governance Committee

     The Corporate Governance Committee consists of four independent directors,
as that term is defined in our Corporate Governance Principles. The Company's
Corporate Governance Committee operates pursuant to a charter, which was filed
with the SEC and can be viewed on our website at www.neose.com (under "About
Neose" or "SEC Filings"). The purpose of the Corporate Governance Committee is
to: (1) identify individuals qualified to become Board members and recommend to
the Board the director nominees for each annual meeting of the stockholders; (2)
recommend to the Board any changes in the Company's Corporate Governance
Principles; (3) lead the Board in its annual review of the Board's performance,
and make recommendations to the Board regarding Board organization, membership,
function and effectiveness, as well as committee structure, membership, function
and effectiveness; (4) recommend to the Board director nominees for each Board
Committee; (5) review the Company's efforts to promote diversity among
directors, officers, employees and contractors; (6) ensure an orientation for
all directors; and (7) perform such other functions as are allocated to it under
the Corporate Governance Principles. The Chairman of our Corporate Governance
Committee, now Dr. Hamilton, chairs the executive sessions of the Board and
otherwise functions as our lead independent director.

                                        6



     Under our By-laws, nominations for director may be made only by the Board
of Directors or a Committee of the Board, or by a stockholder entitled to vote
who delivers notice along with the additional information and materials required
by the By-laws to our Corporate Secretary not less than 120 nor more than 150
days prior to the first anniversary of the date of the proxy statement mailed to
stockholders in connection with the preceding year's annual meeting. For our
annual meeting in the year 2004, we must receive this notice on or after
November 10, 2003 and on or before December 9, 2003. You can obtain a copy of
the By-law provision by writing to our Corporate Secretary, 102 Witmer Road,
Horsham, PA 19044. A copy of our By-laws has been filed with the Securities and
Exchange Commission as an exhibit to our Quarterly Report on Form 10-Q filed on
November 13, 2002.

     Scientific Review Committee

     The Scientific Review Committee consists of one independent director, as
that term is defined in our Corporate Governance Principles, and our founder,
Dr. Roth, who is not independent. The Scientific Review Committee reviews and
evaluates the major research and development programs being conducted by the
Company and determines whether these research and development activities
prudently support our overall business objectives and strategies. The Scientific
Review Committee also reviews major trends in the marketplace and assesses
technologies that we may seek to acquire.

Compensation of Directors

     Directors who are also Neose employees receive no additional compensation
for serving as a director or as a member of any Committee of the Board. Under
our standard arrangements, which are currently under review, each non-employee
director other than Dr. Roth receives annually a retainer of $14,000, which may
be applied, in whole or in part, toward the acquisition of an option to purchase
shares of our common stock. Upon initial election or appointment to the Board of
Directors, each non-employee director receives an option to purchase 30,000
shares of our common stock, and upon re-election to the Board, each non-employee
director other than Dr. Roth receives an option to purchase 10,000 shares of our
common stock. Each automatic option grant has an exercise price equal to the
fair market value on the date of grant. Each automatic grant is immediately
exercisable, and has a term of ten years, subject to earlier termination,
following the director's cessation of service on the Board of Directors. Any
shares purchased upon exercise of the option are subject to repurchase should
the director's service as a non-employee director cease prior to vesting of the
shares. The initial automatic option grant of 30,000 shares vests in successive
equal, annual installments over the director's initial four-year period of Board
service. Each annual automatic option grant vests upon the director's completion
of one year of service on the Board of Directors, as measured from the grant
date. Each outstanding option vests immediately, however, upon certain changes
in the ownership or control of the Company.

     Non-employee directors are also compensated for their services at each
meeting of the Board or Committees on which they serve, at the following rates:
$2,500 for Board meetings attended in person; $2,000 ($2,500 for the Chairman)
for Committee meetings attended in person; and $1,000 for telephonic meetings of
the Board or a Committee lasting longer than 30 minutes.

     All Board members are reimbursed for their reasonable travel expenses
incurred to attend meetings of the Board or Committees of the Board on which
they serve.

Continuing Education of Directors

     The Company is committed to supporting the continuing education of our
directors on relevant matters. During 2002, our new director, Ms. Wyatt,
attended the Directors' Summit presented by the State of Wisconsin Investment
Board at our expense. This annual conference, which is sponsored by
institutional

                                        7



investors, focuses on current corporate governance issues. We plan to support
the attendance of our other new director, Dr. Gage, at this, or a similar,
conference in 2003.

Code of Conduct

     We have a Code of Business Conduct and Ethics, which can be viewed on our
website at www.neose.com (under "About Neose"). We require all employees to
adhere to this Code in addressing the legal and ethical issues encountered in
conducting their work. The Code of Business Conduct and Ethics requires that our
employees avoid conflicts of interest, comply with all laws and other legal
requirements, conduct business in an honest and ethical manner, and otherwise
act with integrity and in the Company's best interest. During 2002, all of our
employees were required to certify that they reviewed and understood this Code.

     The Code of Business Conduct and Ethics includes procedures for reporting
violations of the Code, which are applicable to all employees. The
Sarbanes-Oxley Act of 2002 requires companies to have procedures to receive,
retain and treat complaints received regarding accounting, internal accounting
controls or auditing matters and to allow for the confidential and anonymous
submission by employees of concerns regarding questionable accounting or
auditing matters. The Code of Business Conduct and Ethics also includes these
required procedures.

Copies of Referenced Documents.

     Copies of the documents referred to above that appear on our website are
also available upon request by any stockholder addressed to our Corporate
Secretary, 102 Witmer Road, Horsham, PA 19044.

                     Relationship with Independent Auditors

     The Audit Committee has reappointed KMPG LLP, certified public accountants,
to audit and report on our financial statements for 2003.

     In making its recommendation to ratify the appointment of KPMG LLP as the
Company's independent auditors for the fiscal year beginning January 1, 2003,
the Audit Committee considered whether KPMG LLP's provision of services other
than audit services are compatible with maintaining independence of our public
accountants and auditors. The Audit Committee reviewed the fees described below
for non-audit services and believes such fees are compatible with the
independence of KPMG LLP.

Audit Fees

     The Company has agreed to pay KPMG LLP a total of $65,660 for professional
services for the audit of our annual financial statements for 2002 and for the
review of our interim financial statements, which are included in our Quarterly
Reports on Form 10-Q for 2002.

All Other Fees

     In addition to its audit fees, KPMG LLP has billed the Company a total of
$19,850 for professional services rendered for all services other than Audit
Fees. These other services include (1) $16,350 for other accounting, audit and
tax services related to 2002, and (2) $3,500 for completion of our 2001 tax
returns. We did not engage KPMG LLP during 2002 to provide professional services
with respect to financial information systems design and implementation as
described in Paragraph (c)(4)(ii) of Rule 2-01 of Regulation S-X.

                                        8



KPMG Representatives at Annual Meeting

     We expect that representatives of KPMG LLP will be present at the Annual
Meeting. They will be given the opportunity to make a statement if they desire
to do so, and they will be available to respond to appropriate questions after
the meeting.

Information Relating to Arthur Andersen LLP

     On April 29, 2002, the Board of Directors decided to no longer engage
Arthur Andersen LLP as our independent auditors and engaged KPMG LLP to serve as
our independent auditors to audit our financial statements for the fiscal year
2002.

     Arthur Andersen's reports on the Company's consolidated financial
statements for each of the years ended 2001 and 2000 did not contain an adverse
opinion or disclaimer of opinion, nor were they qualified or modified as to
uncertainty, audit scope or accounting principles.

     During the years ended December 31, 2001 and 2000 and through the date of
this proxy statement, there were no disagreements with Arthur Andersen on any
matter of accounting principle or practice, financial statement disclosure, or
auditing scope or procedure which, if not resolved to Arthur Andersen's
satisfaction, would have caused them to make reference to the subject matter in
connection with their report on our consolidated financial statements for such
years; and there were no reportable events as defined in Item 304(a)(l)(v) of
Regulation S-K.

     During the years ended December 31, 2001 and 2000 and through the date of
the Board's decision, we did not consult KPMG LLP with respect to the
application of accounting principles to a specified transaction, either
completed or proposed, or the type of audit opinion that might be rendered on
our consolidated financial statements, or any other matters or reportable events
as set forth in Items 304(a)(2)(i) and (ii) of Regulation S-K.

     The following additional information is provided as required by the
Securities and Exchange Commission.

     .    Audit Fees. The aggregate fees billed by Arthur Andersen LLP for
          professional services for the 2001 audit and for review of the
          Company's financial statements included in our Quarterly Reports on
          Form 10-Q for 2001 totaled $45,000.
     .    Financial Information Systems Design and Implementation Fees. We did
          not engage Arthur Andersen LLP during 2001 to provide professional
          services with respect to financial information systems design and
          implementation as described in Paragraph (c)(4)(ii) of Rule 2-01 of
          Regulation S-X.
     .    All Other Fees. The aggregate fees billed by Arthur Andersen LLP for
          all other services with respect to 2001, including tax related
          services, totaled $18,000.

After consideration, the Audit Committee determined that the provision by Arthur
Andersen LLP of professional services not related to the audit of the financial
statements referred to above and not related to the reviews of the interim
financial statements referred to above was compatible with maintaining the
independence of Arthur Andersen LLP.

                                        9



                          Report of the Audit Committee

     The following Report of the Audit Committee, the Report of the Compensation
Committee, and the Stock Performance Graph shall not be deemed incorporated by
reference into any other Company filing under the Securities Act of 1933 or the
Securities Exchange Act of 1934, except to the extent specifically incorporated
by reference therein by the Company.

     The Audit Committee of the Board of Directors is comprised of directors who
meet the existing NASDAQ independence standards as well as the heightened
standards for independence included in the NASDAQ corporate governance proposals
and the Company's Corporate Governance Principles. The Chairman of the Audit
Committee qualifies as an "audit committee financial expert" as defined in SEC
Release No. 33-8177 (January 23, 2003). The Audit Committee operates under a
written charter adopted by the Board of Directors, which was reviewed and
revised in September 2002 and which is attached as Appendix A to this Proxy
Statement.

     The Audit Committee met with management during the year to consider the
adequacy of the Company's internal controls and the objectivity of its financial
reporting. The Audit Committee discussed these matters with the Company's
independent auditors and with appropriate Company financial personnel. The Audit
Committee also discussed with the Company's senior management and independent
auditors the process used for certifications by the Company's Chief Executive
Officer and Chief Financial Officer, which is required by the Securities and
Exchange Commission ("SEC") and the Sarbanes-Oxley Act of 2002 for certain of
the Company's filings with the SEC.

     The Audit Committee met eight times during 2002. The Committee schedules
its meetings with a view to ensuring that it devotes appropriate attention to
all of its responsibilities. The Committee's meetings include, whenever
appropriate, executive sessions with the Company's independent auditors without
the presence of the Company's management.

     Management is responsible for the financial reporting process, including
the system of internal controls, and for the preparation of financial statements
in accordance with generally accepted accounting principles. KPMG LLP, the
Company's independent auditors, audited the annual financial statements prepared
by management, expressed an opinion as to whether those financial statements
fairly present the financial position, results of operations and cash flows of
the Company in conformity with generally accepted accounting principles, and
discussed with the Audit Committee any issues they believe should be raised with
the Audit Committee. Our responsibility is to monitor and review these
processes. We are not professionally engaged in the practice of accounting or
auditing. We rely, without independent verification, on the information provided
to us and on the representations made by management and the independent
auditors.

     As part of its oversight of the Company's financial statements, the
Committee reviewed and discussed the Company's audited financial statements with
its independent auditors for the relevant periods with and without management
present. During fiscal 2002, management advised the Committee that each set of
financial statements reviewed had been prepared in accordance with generally
accepted accounting principles, and reviewed significant accounting and
disclosure issues with the Committee. These reviews included discussion with the
outside auditors of matters required to be discussed by Statement on Auditing
Standards No. 61, Communication with Audit Committees, as amended, by the
Auditing Standards Board of the American Institute of Certified Public Auditors.
The Audit Committee has also received the written disclosures and letter from
KPMG LLP required by Independence Standards Board No. 1, Independence
discussions with Audit Committees, and has discussed with KPMG LLP matters
relating to its independence.

                                       10



     Based on the reviews and discussions referred to above, we recommended to
the Board that the financial statements referred to above be included in our
Annual Report on Form 10-K for the year ended December 31, 2002.

Audit Committee of the Board of Directors

Lowell E. Sears, Chairman
William F. Hamilton, Ph.D.
Mark H. Rachesky, M.D.


              Stock Ownership of our Directors, Executive Officers,
                            and 5% Beneficial Owners

     The following table shows information known to us about beneficial
ownership (as defined under the regulations of the Securities and Exchange
Commission) of our common stock by:

     .    Each person we know to be the beneficial owner of at least five
          percent of our common stock;
     .    Each current director (eight of whom are nominees for re-election and
          one of whom is not);
     .    Our new director nominee;
     .    Each executive officer named in our Summary Compensation Table; and
     .    All directors and executive officers as a group.

Unless otherwise indicated, the information is as of March 14, 2003.

     On March 14, 2003, there were 17,207,766 shares of our common stock
outstanding. To calculate a stockholder's percentage of beneficial ownership, we
must include in the numerator and denominator those shares underlying options
that a person has the right to acquire upon the exercise of stock options within
60 days after March 14, 2003. Options held by other stockholders are disregarded
in this calculation. Therefore, the denominator used in calculating beneficial
ownership among our stockholders may differ. Unless we have indicated otherwise,
each person named in the table below has sole voting power and investment power
for the shares listed opposite such person's name.



                                                                         Number of Shares
                                                                          of Common Stock          Percent of
                                                                           Beneficially              Shares
Name of Beneficial Owner                                                       Owned              Outstanding
------------------------                                                 ----------------         -----------
                                                                                            
Eastbourne Capital Management, LLC(1)
1101 Fifth Avenue
Suite 160
San Rafael, CA 94901 ...........................................             2,933,166                17.0%

Kopp Investment Advisors, Inc.(2)
7701 France Avenue South
Suite 500
Edina, MN 55455 ................................................             2,284,384                13.3%

George W. Haywood(3)
c/o Cronin & Vris, LLP
380 Madison Avenue, 24/th/ Floor
New York, NY 10017 .............................................             1,588,866                 9.2%


                                       11



Domain Partners V, L.P.(4)
DP V Associates, L.P.
One Palmer Square
Princeton, NJ 08542 ........................................    949,766     5.5%

Lindsay A. Rosenwald, M.D.(5)
c/o Paramount Capital, Inc.
787 7/th/ Avenue
New York, NY 10019 .........................................    917,280     5.3%


Directors, New Director Nominee  and Named Executive Officers
-------------------------------------------------------------

Mark H. Rachesky, M.D.(6)(7)
   c/o MHR Fund Management LLC
   40 West 57/th/ Street, 33/rd/ Floor
   New York, NY 10019 ......................................    791,648     4.6%

Stephen A. Roth, Ph.D.(6)(8) ...............................    612,224     3.5%
P. Sherrill Neff(6)(9) .....................................    499,396     2.8%
C. Boyd Clarke(6) ..........................................    170,617     1.0%
Douglas J. MacMaster, Jr.(6) ...............................    100,990        *
William F. Hamilton, Ph.D.(6)(10) ..........................     85,152        *
David A. Zopf, M.D.(6) .....................................     83,097        *
Lowell E. Sears(6)(11) .....................................     65,956        *
Marjorie A. Hurley, Pharm.D.(6) ............................     60,885        *
George J. Vergis, Ph.D.(6) .................................     44,360        *
Debra J. Poul(6) ...........................................     14,980        *
Elizabeth Wyatt(6) .........................................      9,505        *
Patrick L. Gage, Ph.D. .....................................      3,500        *
Brian H. Dovey(12) .........................................          0        *

All current directors, the new director nominee, and
executive officers as a group (17 persons)(6) ..............  3,546,155    19.1%

_________
* Less than one percent.

(1)  According to a Schedule 13G/A filed February 13, 2003: (i) Eastbourne
     Capital Management, LLC ("Eastbourne"), is a registered investment advisor
     whose clients (including Black Bear Offshore Master Fund Limited ("BB
     Offshore") and Black Bear Fund I ("BB"), have the right to receive or the
     power to direct the receipt of dividends from, or the proceeds from the
     sale of, the reported shares; (ii) Eastbourne filed the Schedule 13G/A
     jointly with Richard Jon Barry ("Mr. Barry"), who is the controlling member
     of Eastbourne, BB Offshore and BB; (iii) Eastbourne and Mr. Barry comprise
     a group, but they disclaim membership in a group with any other person or
     persons; (iv) BB Offshore and BB filed the Schedule 13G/A jointly with the
     other filers but not as a group, and each expressly disclaims membership in
     a group; (v) each of Eastbourne, Mr. Barry, BB Offshore and BB disclaimed
     beneficial ownership of the reported shares except to the extent of their
     pecuniary interest therein. The foregoing table also includes the following
     shares purchased on February 13, 2003: 301,308 shares purchased by BB
     Offshore, 98,928 shares purchased by BB, and 16,430 purchased by Black Bear
     Fund II, L.L.C.

(2)  According to a Schedule 13G filed January 16, 2003: (i) Kopp Investment
     Advisors, Inc. ("KIA") is an investment adviser registered under the
     Investment Advisers Act of 1940, KIA is wholly owned by Kopp Holding
     Company ("KHC"), and KHC is wholly owned by Mr. Leroy C. Kopp ("Mr. Kopp");
     (ii) KIA reported sole voting power over 923,000 shares, sole dispositive
     power over 725,000 shares and shared dispositive power over 1,951,051;
     (iii) KHC reported beneficial ownership of 1,951,051 shares; (iv) Mr. Kopp
     reported beneficial

                                       12



     ownership of 2,088,551 shares, of which Mr. Kopp reported sole voting and
     dispositive power over 137,500 shares; (v) of the shares beneficially owned
     by KIA, KHC, and Mr. Kopp, 1,926,051 are held in a fiduciary or
     representative capacity. The foregoing table also includes 333,333 shares
     purchased by Kopp Emerging Growth Fund on February 13, 2003.

(3)  In a Schedule 13G filed on January 8, 2003, Mr. Haywood reported sole
     voting and dispositive power over 1,398,000 shares and shared voting and
     dispositive power over 24,200 shares, including 8,200 shares owned by his
     spouse and 16,000 shares owned jointly with his mother. The foregoing table
     also includes 166,666 shares purchased by Mr. Haywood on February 13, 2003.

(4)  According to a Schedule 13D filed on February 24, 2003: (i) each of Domain
     Partners V, L.P., a Delaware limited partnership ("DP V"), and DP V
     Associates, a Delaware limited partnership ("DP V A"), are limited
     partnerships whose principal business is that of a private investment
     partnership; (ii) the sole general partner of DP V and DP V A is One Palmer
     Square Associates V, L.L.C., a Delaware limited liability company ("OPSA
     V"), whose principal business is that of acting as the general partner of
     DP V and DP V A; (iii) James C. Blair, Brian H. Dovey, Jesse I. Treu,
     Kathleen K. Schoemaker, Arthur J. Klausner and Robert J. More are the
     managing members of OPSA V (the "Managing Members"); (iv) the Managing
     Members may be deemed to share the power to vote or direct the voting of
     and to dispose or to direct the disposition of the shares owned by DP V and
     DP V A; (v) the Managing Members disclaim beneficial ownership of the
     shares owned by DP V and DP V A other than the shares he or she may own
     directly, if any, or by virtue of his or her indirect pro rata interest, as
     a Managing Member of OPSA V, in the shares owned by DP V and/or DP V A;
     (vi) DP V reported sole voting and dispositive power over 927,848 shares;
     (vii) DP V A reported sole voting and dispositive power over 21,918 shares;
     and (viii) DP V and DP V A may constitute a "group" within the meaning of
     Section 13(d)(3) of the Securities Act of 1934, as amended.

(5)  According to a Schedule 13G/A filed on February 19, 2003: (i) Dr. Rosenwald
     is an investment banker, venture capitalist, fund manager and sole
     stockholder and chairman of Paramount Capital Asset Management, Inc., a
     Delaware corporation; (ii) Dr. Rosenwald reported sole voting and
     dispositive power over 396,111 shares and shared voting and dispositive
     power over 521,169 shares; and (iii) the reported shares include: (a)
     521,169 shares of which Paramount Capital may be deemed the owner; (b)
     152,157 shares of which Aries Domestic may be deemed the beneficial owner;
     (c) 32,534 shares of which Aries II may be deemed the beneficial owner; (d)
     336,478 shares of which Aries Fund may be deemed the beneficial owner; and
     (e) 31,785 shares which Dr. Rosenwald has the right to purchase under
     options exercisable within 60 days.

(6)  Includes the following shares of common stock issuable under stock options
     that are exercisable within 60 days after March 14, 2003: Rachesky - 36,258
     shares; Roth - 398,333 shares; Neff - 403,040 shares; Clarke - 135,417
     shares; MacMaster - 71,139 shares; Hamilton - 26,402 shares; Zopf - 79,791
     shares; Sears - 44,632 shares; Hurley - 54,958 shares; Vergis - 42,917
     shares; Poul - 8,125 shares; Wyatt - 9,505 shares; and all current
     directors, the new director nominee, and executive officers as a group -
     1,380,491 shares.

(7)  Includes (i) 210,526 shares of common stock held by MHR Capital Partners
     LP, (ii) 502,759 shares of common stock held by MRL Partners LP, and (iii)
     42,105 shares of common stock held by OTT LLC. Dr. Rachesky is the managing
     member of MHR Advisors LLC, which is the General Partner of MHR Capital
     Partners and MRL Partners. Dr. Rachesky is the managing member of OTT LLC.
     Dr. Rachesky may be deemed to have voting and investment control over the
     shares held by MHR Capital Partners, MRL Partners, and OTT LLC. Dr.
     Rachesky disclaims beneficial ownership of the shares held by MHR Capital
     Partners, MRL Partners, and OTT LLC, except to the extent of his pecuniary
     interest in the funds.

(8)  Includes 100,000 shares of common stock owned by Dr. Roth's wife and 15,758
     shares of common stock owned by Dr. Roth's daughter. Dr. Roth disclaims
     beneficial ownership of the shares held by his wife and daughter.

(9)  Includes 1,000 shares of common stock owned by Mr. Neff's wife. Mr. Neff
     disclaims beneficial ownership of the shares held by his wife.

(10) Excludes 43,070 shares of common stock which are exercisable within 60 days
     under options that were transferred by Dr. Hamilton in December 2002
     pursuant to a domestic relations order. Dr. Hamilton disclaims beneficial
     interest in these transferred options.

                                       13



(11) Includes 21,324 shares of common stock owned by the Sears Family Living
     Trust, of which Mr. Sears is trustee.

(12) Mr. Dovey is a Managing Member of One Palmer Square Associates V, L.L.C.,
     which is the general partner of Domain Partners V, L.P. ("DP V") and DP V
     Associates, L.P. ("DP V A"), and is nominated for election as a director of
     the Company. Mr. Dovey disclaims beneficial ownership of the shares held by
     DP V and DP V A, except to the extent of his pecuniary interest in such
     shares. See note (4) above for additional information about the beneficial
     ownership of shares held by DP V and DP V A.

             Section 16(a) Beneficial Ownership Reporting Compliance

       Based solely upon a review of reports of stock ownership (and changes in
stock ownership) and written representations received by us, we believe that our
directors and executive officers met all of their filing requirements under
Section 16(a) of the Securities and Exchange Act of 1934 during the year ended
December 31, 2002.

                       Proposal 1 -- Election of Directors

Nominees for Election

       The Board of Directors currently has nine members. P. Sherrill Neff, a
director since 1994 and a former officer of the Company, will retire from the
Board on May 13, 2003. We thank him for his years of valued service. The Board
of Directors has determined that the Board will remain fixed at nine directors
at the Annual Meeting on May 13, 2003. Each member, other than Mr. Neff, has
been nominated for re-election, and has agreed, if elected, to serve a one-year
term or until the election and qualification of his or her successor. Upon the
recommendation of the Corporate Governance Committee, the Board has also
nominated Brian H. Dovey for election to the Board. If any nominee is unable to
stand for election, which circumstance we do not anticipate, the Board may
provide for a lesser number of directors or designate a substitute. In the
latter event, shares represented by proxies may be voted for a substitute
nominee.

       If a quorum is present at the Annual Meeting, then a plurality of all
votes cast at the meeting will be sufficient to elect a director. There is no
cumulative voting in the election of directors.

       The Board of Directors recommends a vote "FOR" each of the nominees.

       C. Boyd Clarke, 54, has served on our Board, and as President and Chief
Executive Officer, since March 2002. From December 1999 through March 2002, Mr.
Clarke was President and Chief Executive Officer of Aviron, a biotechnology
company developing vaccines, which was acquired by MedImmune, and was also
Chairman from January 2001 through March 2002. From 1998 through 1999, Mr.
Clarke was Chief Executive Officer and President of U.S. Bioscience, Inc., a
biotechnology company focused on products to treat cancer, which also was
acquired by MedImmune. Mr. Clarke served as President and Chief Operating
Officer of U.S. Bioscience, Inc. from 1996 to 1998. From 1977 to 1996, Mr.
Clarke held a number of positions at Merck & Co., Inc., including being the
first President of Pasteur-Merieux MSD, and most recently as Vice President of
Merck Vaccines. Mr. Clarke has a B.S. in biochemistry, and an M.A. in history
from the University of Calgary. Mr. Clarke also serves on the Board of Trustees
of the Textile Museum in Washington, D.C.

       Brian H. Dovey, 61, is nominated to serve on our Board for the first time
this year. He is a managing member of Domain Associates, L.L.C., a private
venture capital management firm focused on life sciences, and has served in this
or similar capacities with the firm since 1988. He has served as Chairman of

                                       14



three companies and on the Board of Directors of some 20 additional companies,
including Align Technology, Inc. and Cardiac Science, Inc. Prior to joining
Domain, Mr. Dovey spent six years at Rorer Group, Inc. (now Aventis) and as
President (1986 to 1988) was the primary architect of this Fortune 500 company's
strategic shift to pharmaceuticals resulting in a doubling of annual sales to
approximately $1 billion. Previously, he was President of Survival Technology,
Inc., a start-up medical products company whose sales growth placed it in the
top ten of the Inc 100. He also held management positions with Howmedica, Inc.,
Howmet Corporation, and New York Telephone. Mr. Dovey has served as both
President and Chairman of the National Venture Capital Association and is on the
Board of Trustees for the Coriell Institute, the Wistar Institute and the
Burnham Institute. Mr. Dovey received his B.A. from Colgate University and an
M.B.A. degree from the Harvard Business School.

     L. Patrick Gage, Ph.D., 60, has served on our Board since October 2002. Dr.
Gage is Chairman of Compound Therapeutics, a private biotechnology company, and
Chairman of the Dublin (IE) Molecular Medicine Centre. He is also an advisor to
the Life Sciences Research Foundation, Perkin Elmer, Inc. and Warburg Pincus
LLC. Dr. Gage served as Senior Vice President, Science and Technology, at Wyeth
from 2001 to 2002, and as President of Wyeth Research from 1998 to 2002. Prior
to Wyeth, Dr. Gage held positions of increasing responsibility at Genetics
Institute, Inc. from 1989 to 1998, culminating with his service as President
after the company was acquired by Wyeth. He also spent 18 years at Hoffmann-La
Roche, Inc. in various scientific and management positions. Dr. Gage serves as a
director of the Biotechnology Institute and the Philadelphia Orchestra
Association. Dr. Gage has a B.S. in physics from Massachusetts Institute of
Technology and a Ph.D. from the University of Chicago.

     William F. Hamilton, Ph.D., 63, has served on our Board since 1991. Dr.
Hamilton has served on the University of Pennsylvania faculty since 1967, and is
the Landau Professor of Management and Technology, and Director of the Jerome
Fisher Program in Management and Technology at The Wharton School and the School
of Engineering and Applied Science. He serves as a director of Digital
Lightwave, Inc., a publicly-held manufacturer of telecommunications test
equipment. Dr. Hamilton received his B.S. and M.S. in chemical engineering and
his M.B.A. from the University of Pennsylvania, and his Ph.D. in applied
economics from the London School of Economics.

     Douglas J. MacMaster, Jr., 72, has served on our Board since 1993. Mr.
MacMaster served as Senior Vice President of Merck & Co., Inc. from 1988 to
1992, where he was responsible for worldwide chemical and pharmaceutical
manufacturing, the Agvet Division, and the Specialty Chemicals Group. From 1985
to 1988, Mr. MacMaster was President of the Merck Sharp Dohme Division of Merck.
Mr. MacMaster serves as a director of the following publicly-held companies:
Stratton Mutual Funds, and Martek Biosciences Corp., a biological products
manufacturing company. He received his B.A. from St. Francis Xavier University,
and his J.D. from Boston College Law School.

     Mark H. Rachesky, M.D., 44, has served on our Board since 1999. Dr.
Rachesky is the founder and President of MHR Fund Management LLC and affiliates,
investment managers of various private investment funds that invest in
inefficient market sectors, including special situation equities and distressed
investments. From 1990 through June 1996, Dr. Rachesky was employed by Carl C.
Icahn, initially as a senior investment officer and for the last three years as
sole Managing Director of Icahn Holding Corporation, and acting chief investment
advisor. Dr. Rachesky is currently on the Board of Directors of Samsonite
Corporation and Keryx Biopharmaceuticals, Inc. Dr. Rachesky is a graduate of
Stanford University School of Medicine, and Stanford University School of
Business. Dr. Rachesky graduated from the University of Pennsylvania with a
major in Molecular Aspects of Cancer.

     Stephen A. Roth, Ph.D., 60, has served on our Board since 1989, and as
Chairman from 1994. Dr. Roth is President and Chief Executive Officer of Immune
Control, Inc. He co-founded Neose, served as Chief Executive Officer from August
1994 until March 2002, and now serves as a consultant. From 1992 until August
1994, he served as Senior Vice President, Research and Development and Chief
Scientific

                                       15



Officer. Dr. Roth was on the faculty of the University of Pennsylvania from 1980
to 1994, and was Chairman of Biology from 1982 to 1987. Dr. Roth received his
A.B. in biology from The Johns Hopkins University, and his Ph.D. in
developmental biology from the Case Western Reserve University. He completed his
post-doctorate training in carbohydrate chemistry at The Johns Hopkins
University.

     Lowell E. Sears, 52, has served on our Board since 1994. He has been a
private investor involved in portfolio management and life sciences venture
capital since April 1994. From 1988 until April 1994, Mr. Sears was Chief
Financial Officer of Amgen Inc., a pharmaceutical company, and from 1992 until
1994, he also served as Senior Vice President responsible for the Asia-Pacific
region. Mr. Sears is a director of Techne Corp., which is a publicly-held
biotechnology company. Mr. Sears received his B.A. in economics from Claremont
McKenna College, and his M.B.A. from Stanford University.

     Elizabeth H.S. Wyatt, 55, has served on our Board since May 2002. From 1980
through December 2000, Ms. Wyatt held a variety of positions at Merck & Co.,
Inc., most recently as Merck's Vice President, Corporate Licensing, heading
Merck's worldwide product and technology acquisition activities. Prior to
joining Merck in 1980, Ms. Wyatt was a consultant and an academic administrator,
responsible for the Harvard Business School's first formal marketing of its
executive education programs. She currently serves on the Boards of Directors of
MedImmune, Inc. and ARIAD Pharmaceuticals, and on the Board of Trustees of
Randolph-Macon College. Ms. Wyatt received her B.A., magna cum laude, from Sweet
Briar College, an M. Ed. in counseling psychology from Boston University, and an
M.B.A. with honors from Harvard University.

How are directors nominated?

     The Board of Directors has nominated each current director to stand for
re-election based upon the recommendations of the Corporate Governance
Committee. One of our directors, Dr. Rachesky, was nominated in accordance with
an agreement by the Company to use its best efforts to cause the Board to
nominate the nominee of MHR Capital Partners for election as a Board member, as
long as MHR Capital Partners or its affiliates own at least 200,000 shares of
Neose common stock. See the discussions under the headings "Corporate Governance
Committee" and "Requirements for Advance Notification of Nominations and
Stockholder Proposals" beginning on pages 6 and 36, respectively, for
information about procedures for stockholder nomination of directors.

How many Board and Committee Meetings were held during 2002?

     During 2002, the Board of Directors held nine meetings, the Audit Committee
held eight meetings, the Compensation Committee held five meetings, and the
Corporate Governance Committee held two meetings. Each director attended at
least 75 percent of the total number of meetings of the Board and Committees on
which he or she served, except Dr. Rachesky.

                                       16



                             Executive Compensation

Summary Compensation Table

     The following table provides information about all compensation earned in
2002, 2001, and 2000 by the individuals who served as Chief Executive Officer
during 2002, and the four other most highly compensated executive officers
during 2002.



                                                                                      Long-term
                                                                                    Compensation
                                                                                    ------------
                                                                                       Shares
                                                       Annual Compensation           Underlying           All Other
                                                    -------------------------
Name and Principal Position              Year         Salary          Bonus          Options (#)         Compensation
----------------------------------     --------     -----------    ----------       ------------       ----------------
                                                                                        
C. Boyd Clarke(1)                        2002        $ 339,231       $ 254,423            750,000        $ 397,346(2)
   President and Chief Executive
   Officer

Stephen A. Roth(3)                       2002           79,245           --                  --            368,227(4)
   Chairman and Former Chief             2001          294,866         147,433             50,000            5,682(4)
   Executive Officer                     2000          274,294         109,718             50,000            5,472(4)

David A. Zopf                            2002          240,413          96,065             30,000            5,836(5)
   Executive Vice President              2001          200,136          45,021             25,000            5,646(5)
                                         2000          180,303          54,091             25,000            4,962(5)

Debra J. Poul(6)                         2002          213,333          67,500             85,000            5,180(6)
   Senior Vice President and             2001          144,933          20,925              7,500            4,460(6)
   General Counsel                       2000          102,462          16,200             10,000            1,788(6)

George J. Vergis(7)                      2002          220,500          66,150             35,000            5,836(8)
   Senior Vice President, Business       2001           93,154          47,250            180,000              180(8)
   and Commercial Development

Marjorie A. Hurley                       2002          153,086          39,468             15,000            4,383(9)
   Vice President, Regulatory            2001          137,998          21,114             12,000            4,092(9)
   Affairs and Project Management        2000          125,453          16,936             10,000            3,778(9)


__________
(1)  Mr. Clarke joined Neose in March 2002.
(2)  Includes $397,094 during 2002 of reimbursement of relocation expenses to
     Mr. Clarke, and $252 in premiums paid by us for group term life insurance.
(3)  Dr. Roth was employed by Neose, and served as chief executive officer,
     until March 2002.
(4)  Includes $356,603 paid to Dr. Roth for consulting fees pursuant to his
     Separation and Consulting Agreement; $10,000 paid to Dr. Roth's attorney
     for services rendered to Dr. Roth for negotiating that agreement; and
     $1,540, $5,250, and $5,040 of matching contributions in 2002, 2001, and
     2000, respectively, to Dr. Roth's account in our 401(k) plan. Also includes
     $84, $432, and $432 in 2002, 2001, and 2000, respectively in premiums paid
     by us for group term life insurance.
(5)  Includes $5,500, $5,214, and $4,530 of matching contributions in 2002,
     2001, and 2000, respectively, to Dr. Zopf's account in our 401(k) Plan.
     Also includes $336, $432, and $432 in 2002, 2001, and 2000, respectively in
     premiums paid by us for group term life insurance.
(6)  Ms. Poul joined Neose in January 2000 and served on a part-time basis until
     May 2002. Includes $5,500, $4,028, and $1,500 of matching contributions in
     2002, 2001, and 2000, respectively, to Ms. Poul's account in our 401(k)
     Plan. Also includes $336, $432, and $288 in 2002, 2001, and 2000,
     respectively in premiums paid by us for group term life insurance.
(7)  Dr. Vergis joined Neose in July 2001.
(8)  Includes $5,500 of matching contributions in 2002 to Dr. Vergis' account in
     our 401(k) plan. Also includes $336 and $180 in 2002 and 2001,
     respectively, in premiums paid by us for group term life insurance.
(9)  Includes $5,500, $3,660, and $3,346 of matching contributions in 2002,
     2001, and 2000, respectively, to Dr. Hurley's account in our 401(k) Plan.
     Also includes $336, $432, and $432 in 2002, 2001, and 2000, respectively in
     premiums paid by us for group term life insurance.

                                       17



                              Employment Agreements

     In March 2002, we entered into an employment agreement with C. Boyd Clarke
when he joined the Company as our President and Chief Executive Officer. Under
this agreement, which includes non-competition and confidentiality covenants:

     .    The Company agreed that Mr. Clarke would receive a minimum base salary
          of $450,000 per year, and an annual performance incentive bonus, with
          a target amount of 75% of base salary based upon the achievement of
          annual goals established by the Board of Directors and Mr. Clarke,
          which were established soon after his arrival at the Company with
          respect to 2002;

     .    The Board of Directors granted Mr. Clarke options to purchase 500,000
          shares of common stock at an exercise price of $32.05 per share, the
          fair market value on the date of grant, as follows:

               an incentive stock option to purchase 12,480 shares, which option
               vests totally in four years from the date of grant, with 3,120
               shares vesting on March 29, 2003, 260 shares vesting on the last
               day of each of the 24 months in 2004 and 2005, and an additional
               1,040 shares vesting on the last day of each of the first three
               months of 2006; and

               a non-qualified stock option to purchase 487,520 shares, which
               option vests totally in four years from the date of grant, with
               121,880 shares vesting on March 29, 2003, and shares vesting on a
               monthly basis thereafter such that an aggregate of 93,750,
               121,880, 121,880 and 28,130 options vest in each of the remainder
               of 2003, 2004, 2005, and the first three months of 2006,
               respectively.

     .    The Company agreed to reimburse Mr. Clarke for job-related expenses
          and reasonable costs related to the relocation of his residence to
          Pennsylvania, including travel expenses, temporary housing costs,
          realtor fees not to exceed $180,000, moving costs, closing costs in
          connection with the purchase of a new home, and $25,000 to defray
          additional miscellaneous expenses. Each of these payments is subject
          to partial repayment by Mr. Clarke in the event he resigns from Neose
          other than for good reason, as defined in the agreement.

     .    In the event that Mr. Clarke is involuntarily terminated without cause
          or resigns for good reason (each as defined in the agreement),
          provided that Mr. Clarke and Neose enter into a mutual release of
          claims, Mr. Clarke would receive on the date of such termination a
          cash payment equal to one year of base salary, target annual bonus for
          the year in which the termination occurs, and any unpaid bonus amounts
          from prior years. Additionally, all outstanding options that would
          have vested in the 12 months following termination would immediately
          vest and remain exercisable for 12 months following termination.

     .    In the event that Mr. Clarke is involuntarily terminated without cause
          or resigns for good reason (each as defined in the agreement) within
          18 months following certain changes of control of Neose or a sale of
          all or substantially all of our assets in a complete liquidation or
          dissolution, provided that Mr. Clarke and Neose enter into a mutual
          release of claims, Mr. Clarke would receive on the date of such
          termination a cash payment equal to two years of base salary, two
          times the target annual bonus for the year in which termination
          occurs, and any unpaid bonus amounts from prior years. Additionally,
          all outstanding options would immediately vest and remain exercisable
          for 12 months following termination.

     .    In the even that payments to Mr. Clarke under the employment agreement
          would result in the imposition of a parachute excise tax under
          Internal Revenue Code Section 4999, Mr. Clarke

                                       18



               would be entitled to receive an additional "gross-up" payment to
               insulate him from the effect of that tax.

                          Change of Control Agreements

     During the third quarter of 2002, we entered into change of control
agreements with Drs. Zopf, Vergis, and Hurley and Ms. Poul. In the event any of
these executive officers is involuntarily terminated without cause (as defined
in the agreement), the executive would receive on the date of termination a cash
payment equal to six months base salary. The Company also would arrange for
outplacement services for the employee and provide medical benefits to the
employee (and his or her spouse and dependents, if they were covered immediately
prior to such termination) for six months, at a monthly cost to the employee
equal to the monthly cost of such coverage, if any, to the employee immediately
prior to such termination.

     In the event that any of these executive officers is involuntarily
terminated without cause or resigns for good reason within 12 months following a
change of control (each as defined in the agreement), the executive would
receive on the date of termination a cash payment equal to one year of base
salary and the employee's target annual bonus for the year in which the
termination occurs. Additionally, all outstanding options that would have vested
in the 12 months following termination would immediately vest and remain
exercisable for 12 months following termination. The Company also would arrange
for outplacement services for the employee and provide medical benefits to the
employee (and his or her spouse and dependents, if they were covered immediately
prior to such termination) for 12 months, at a monthly cost to the employee
equal to the monthly cost of such coverage, if any, to the employee immediately
prior to such termination. In the event payments to any executive under the
change of control agreement would result in the imposition of a parachute excise
tax under Section 280(G) of the Internal Revenue Code, the executive would be
entitled to receive an additional "gross-up" payment to insulate the executive
from the effect of that tax.

     The change of control agreements require these executives to release the
Company from certain claims and to comply with certain restrictive covenants.

                       Separation and Consulting Agreement

     In March 2002, we entered into a Separation and Consulting Agreement with
Stephen A. Roth, Ph.D., who was our Chief Executive Officer. Under this
agreement, Dr. Roth agreed to provide consulting services to the Chief Executive
Officer and the Board of Directors for a period of 12 months, and the Company
agreed to provide health insurance benefits to Dr. Roth and pay him $39,622 per
month for 12 months. In March 2003, Dr. Roth extended his non-competition and
non-solicitation commitments, and his consulting obligations, for two additional
years under a separate non-competition agreement with the Company. As a result,
we will extend the $39,622 monthly payments for 24 additional months and, for
purposes of stock option vesting and exercisability, treat Dr. Roth as remaining
in service to Neose until the third anniversary of his resignation as Chief
Executive Officer (or until the end of his service as a director, if later). Dr.
Roth also released us from any obligations we may have incurred in connection
with his employment with us.

     Dr. Roth is no longer an employee of the Company, but continues to serve as
a director and consultant. Under the Company's Principles of Corporate
Governance, he is not an "independent" director.

                                       19



                            Option Grants During 2002

     The following table provides information about grants of stock options made
during 2002 to each of the executive officers named in our Summary Compensation
Table.



                                          Individual Grants
                     ---------------------------------------------------------------
                                                                                          Potential Realizable Value
                             Number of                                                    at Assumed Annual Rates of
                              Shares       Percentage of                                 Stock Price Appreciation for
                            Underlying     Total Options                                         Option Term (2)
                              Options       Granted to        Exercise    Expiration     -----------------------------
Name                          Granted      Employees (1)        Price        Date             5%              10%
----                          -------      -------------        -----     ----------     ------------    -------------
                                                                                      
C. Boyd Clarke ...........   500,000(3)        33.9%            $32.05     03/29/12    $ 10,078,036     $ 25,539,723
                             250,000(4)        17.0               8.75     12/24/12       1,375,707        3,486,312
Stephen A. Roth ..........        --             --                 --           --              --               --
David A. Zopf ............    30,000(4)         2.0              10.62     12/12/12         200,366          507,766
Debra J. Poul ............    50,000(4)         3.4              11.61     05/27/12         365,073          925,168
                              35,000(4)         2.4              10.62     12/12/12         233,760          592,394
George J. Vergis .........    35,000(4)         2.4              10.62     12/12/12         233,760          592,394
Marjorie A. Hurley .......    15,000(4)         1.0              11.61     05/27/12         109,522          277,550


____________

(1)  Based on a total of 1,473,800 options granted during 2002 to employees to
     purchase common stock.
(2)  The potential realizable value of each grant is calculated assuming that
     the market price per share of common stock appreciates at annualized rates
     of 5% and 10% over the ten-year option term. The results of these
     calculations are based on rates set forth by the Securities and Exchange
     Commission and are not intended to forecast possible future appreciation of
     the price of our common stock.
(3)  Includes (i) an incentive stock option to purchase 12,480 shares, which
     option vests totally in four years from the date of grant, with 3,120
     vesting on March 29, 2003, 260 shares vesting on the last day of each of
     the 24 months in 2004 and 2005, and an additional 1,040 shares vesting on
     the last day of each of the first three months of 2006; and (ii) a
     non-qualified stock option to purchase 487,520 shares, which option vests
     totally in four years from the date of grant, with 122,880 shares vesting
     on March 29, 2003, and shares vesting on a monthly basis thereafter such
     that an aggregate of 93,750, 121,880, 121,880 and 28,130 options vest in
     each of the remainder of 2003, 2004, 2005, and the first three months of
     2006, respectively.
(4)  Each option has a term of ten years from the date of grant and vests
     ratably over a four-year period, beginning on the first anniversary of the
     date of grant.

                      Option Exercises and Values for 2002

     The following table provides information about the exercise of stock
options during 2002 and the value of stock options unexercised at the end of
2002 for the executive officers named in our Summary Compensation Table. The
value of unexercised stock options is calculated by multiplying the number of
option shares by the differences between the option exercise price and the
year-end stock price.



                                                               Number of Shares
                             Number of                     Underlying Unexercised             Values of Unexercised
                              Shares                                Options                    In-The-Money Options
                            Acquired On        Value      ----------------------------     ----------------------------
Name                         Exercise         Realized    Exercisable    Unexercisable     Exercisable    Unexercisable
----                         --------         --------    -----------    -------------     -----------    -------------
                                                                                        
C. Boyd Clarke ..........          --         $     --             --       750,000        $     --        $    --
Stephen A. Roth .........          --               --        398,333        70,000          60,123             --
David A. Zopf ...........      20,899          629,060         79,791        64,375              --             --
Debra J. Poul ...........          --               --          6,875        95,625              --             --
George J. Vergis ........          --               --         42,917       172,083              --             --
Marjorie A. Hurley ......       3,481           29,623         54,958        30,875          18,619             --


                                       20



                      Report of the Compensation Committee

What is our compensation philosophy?

     The goal of our compensation program is to attract, motivate and retain the
highly talented individuals the Company needs to develop proprietary products
and provide services to our customers. Our philosophy is to provide competitive
compensation levels, but to tie compensation to individual and company
performance. We have established both corporate objectives, and individual
objectives, against which we can measure performance and determine appropriate
compensation levels. We believe in leveraging compensation by increasing the
variable component, particularly for senior executives, so that they will be
rewarded based on the achievement of corporate and individual goals. We also
believe that all employees should participate in some equity-based compensation
program.

What are the components of our executive compensation?

     The elements of our executive compensation are:

     .    Base salary;
     .    Variable compensation, consisting of annual cash bonuses based on
          performance to objectives; and
     .    Equity compensation, consisting of annual grants of long-term stock
          options.

     We have included these three components to attract and retain senior
management, to encourage senior management to achieve our corporate objectives,
and to align their interests with the interests of our stockholders.

How do we determine base salaries?

     We determine base salaries by each individual's experience and personal
performance, and by comparisons to similar positions within the biotechnology
industry. In general, base salaries are reviewed annually based on these
criteria. This year, as we focus our resources on the achievement of our
corporate objectives, consistent with our philosophy of emphasizing variable
compensation, we have frozen for one year the salary of our chief executive
officer, and have frozen for at least six months the salaries of our vice
presidents.

How do we determine annual bonuses?

     We believe that our senior executives have the greatest impact on the
achievement of our corporate objectives and their compensation should therefore
be heavily dependent on individual and corporate performance. We have instituted
a management by objectives program designed to establish clear objectives, for
both the company and each individual, as a way to communicate our expectations
to our employees and to measure their performance. We set target bonus
percentages for different levels of employees, to be applied depending on the
performance to individual and corporate objectives. For 2002, our chief
executive officer's bonus was based on the achievement of the corporate
objectives agreed to by the Board and Mr. Clarke, and for our other senior
executives, bonuses were based 50% on each senior executive's performance to
objectives, and 50% on the company's performance. The Compensation Committee
approved bonuses payable to our executive officers based on performance in 2002
totaling $606,796, which were paid in 2003. The Compensation Committee approved
bonuses payable to our executive officers based on performance in 2001 totaling
$509,996, which were paid in 2002.

                                       21



How is equity compensation used to ensure senior management is focused on
long-term results?

     We use stock options to provide long-term incentives to our executive
officers. In this way, we seek to align their interests with those of our
stockholders, and to retain our senior management.

     We have adopted guidelines for stock option grants based on job level. In
addition, when determining the number of options to grant, we look at the
individual's and the company's performance to objectives, as well as comparable
information of other biotechnology companies. Options granted to our executive
officers were based on our guidelines, as well as performance.

     The Compensation Committee approves all grants of stock options to
executive officers. Generally, each option is exercisable over a ten-year period
at the market price on the date of grant and vests in annual installments over a
four-year period. In connection with the recruitment of key executives, we have
made exceptions to the vesting schedules of certain grants. This was the case
for the options granted to Mr. Clarke when he was hired (which are described in
note 3 to the table of Option Grants During 2002 on page 20), and for options
that vest based on performance criteria which were granted in 2002 to our new
Senior Vice President, Pharmaceutical Development and Operations, and in 2001 to
our new Vice President, Business and Commercial Development.

     Our stock options will provide a benefit to the executive officer only if
he or she remains employed (or is deemed employed) by Neose during the vesting
period, and then only if the market price of our common stock increases. During
2002, the Compensation Committee approved grants to purchase 1,285,000 shares of
common stock to our executive officers, of which 750,000 were granted to Mr.
Clarke, 355,000 were granted in connection with the hiring of two new executive
officers, 150,000 were granted in connection with promotions of four of our
executive officers, and 30,000 were granted as a special award to one executive
officer. No regular annual performance grants were made in 2002, because annual
grants based on performance during 2001 were granted in 2001 and annual grants
based on performance in 2002 were granted in 2003. However, the number of
options granted in 2002 was significantly higher than the number of options
granted in 2001, primarily because of grants made to recruit new members of
senior management.

How do we determine the compensation of our Chief Executive Officer?

     We hired Mr. Clarke in March 2002. His compensation was designed to attract
him to Neose, to be competitive with the compensation packages offered by
comparable companies, and to make a significant percentage contingent on his and
our performance. We agreed to pay him a minimum base salary of $450,000 per year
and a performance incentive bonus, with a target amount of 75% of base salary,
based upon the achievement of goals established by the Board of Directors and
Mr. Clarke. Mr. Clarke was paid a bonus of $254,423 for 2002, which was 75% of
his base salary, consistent with his employment agreement. We awarded his bonus
based upon our analysis of the Company's performance to specific objectives
under his leadership.

     Mr. Clarke was provided a hiring inducement that included options to
purchase 500,000 shares of common stock at an exercise price of $32.05 per
share. Later in the year, in response to concerns raised by some of our
investors and recognizing Mr. Clarke's importance to the Company, the
Compensation Committee decided that it was in the best interest of the Company
and its stockholders to grant Mr. Clarke additional options. Implementing this
decision in December 2002, the Committee granted Mr. Clarke options to purchase
250,000 shares of common stock at an exercise price of $8.75 per share (the
closing price on the date of grant), which vest in four equal annual
installments beginning on the first anniversary of the grant date.

                                       22



What is the impact of Internal Revenue Code Section 162(m)?

     Under Section 162(m) of the Internal Revenue Code, we will not be allowed a
federal income tax deduction for compensation paid to certain executive
officers, to the extent that compensation exceeds $1 million per executive
officer in any one year. Compensation that qualifies as performance-based
compensation is not taken into account for purposes of the limitation. The
definition of performance-based compensation includes compensation deemed paid
in connection with the exercise of certain stock options. The exercised stock
options must have an exercise price equal to the fair market value of the option
shares on the grant date to qualify as performance-based compensation. Our
Amended and Restated 1995 Stock Option/Stock Issuance Plan is intended to assure
that the exercise of such stock options will qualify as performance-based
compensation. The non-qualified option granted to Mr. Clarke upon commencement
of his employment was not granted under the 1995 Stock Option/Stock Issuance
Plan and is not intended to qualify for the performance-based exemption under
Section 162(m).

     The Compensation Committee has not taken any action to limit or restructure
the elements of cash compensation payable to our executive officers. The
Compensation Committee will reconsider this decision should the individual
compensation of any executive officer approach the $1 million level.

Compensation Committee of the Board of Directors

Douglas J. MacMaster, Jr., Chairman
L. Patrick Gage, Ph.D.
Elizabeth H.S. Wyatt



                  Certain Relationships and Related Transaction

     In May 2001, we entered into a tuition reimbursement agreement with A.
Brian Davis, who serves as our Vice President, Finance. Under the agreement, we
agreed to lend Mr. Davis the amounts necessary to pay for tuition payments and
related costs and fees for an MBA degree. Interest accrues on the loan at 4.71%
per year, and is payable annually beginning in May 2002. We have agreed to
forgive repayment of the principal amount outstanding in four equal, annual
installments commencing in May 2004 if he remains employed by us on each
forgiveness date. We will forgive the accrued interest as it becomes due and, if
Mr. Davis is terminated without cause, we will forgive all outstanding principal
and interest. As of December 31, 2002, the amount outstanding under the
agreement, including accrued interest, was approximately $121,000.

                                       23



                         Common Stock Performance Graph

     The following graph assumes that $100 was invested on December 31, 1997, in
our common stock. The graph compares the cumulative return, which includes the
reinvestment of dividends, of this investment with an equivalent investment on
that date in the Nasdaq Stock Market - U.S. Index (the "Nasdaq Composite") and
the Nasdaq Stock Market Biotech Index (the "Nasdaq Biotech Index").

                                     [GRAPH]


                       Ntec                   Nasdaq                  Biotech

     12/31/1997         100                      100                      100
     12/31/1998       81.18                   140.99                   144.28
     12/31/1999       94.29                   262.44                   290.92
     12/31/2000      216.39                   157.42                   357.80
     12/31/2001      240.13                   124.89                   299.83
     12/31/2002       56.65                    86.33                   163.92

Proposal 2 -- Ratification of Appointment of Independent Auditors

     The Audit Committee of the Board of Directors has appointed KPMG LLP as the
Company's independent auditors to audit its financial statements for the year
ending December 31, 2003. KPMG LLP has served as the Company's auditors since
April 2002. Services provided to the Company by KPMG LLP during 2002 are
described under "Relationship with Independent Auditors" on page 8.

     Representatives of KPMG LLP are expected to be present at the Annual
Meeting to respond to appropriate questions and to make such statements as they
may desire.

     The Board of Directors recommends that stockholders vote "FOR" ratification
of the appointment of KPMG LLP as the Company's auditors for fiscal 2003.

     In the event that the stockholders do not ratify the appointment, the
appointment will be reconsidered by the Audit Committee.

                                       24



         Proposal 3 -- Amendment to our Amended and Restated 1995 Stock
                           Option/Stock Issuance Plan

Proposed Amendment

     At the Annual Meeting, a proposal will be presented to the stockholders to
approve and adopt an amendment to our Amended and Restated 1995 Stock
Option/Stock Issuance Plan to increase by 825,000 shares the number of shares of
common stock authorized under the stock option plan. As of the record date for
the Annual Meeting, March 21, 2003, 825,000 shares represented 4.8% of the
outstanding shares of our common stock. Of the 5,051,666 shares currently
authorized under the stock option plan, 727,441 shares have been issued pursuant
to option exercises and are no longer available for grant. Of the remaining
4,324,225 shares available for grant under the stock option plan, options to
purchase 4,172,065 shares of common stock were outstanding as of March 21, 2003,
and options to purchase 152,160 shares remained available for future grants.

     In February 2003, the Board adopted the amendment, subject to approval by
our stockholders. We believe that our ability to grant options under the stock
option plan is a valuable and necessary compensation tool that aligns the
long-term financial interests of employees and directors with the financial
interests of our stockholders. In addition, we believe that the stock option
plan helps us to attract, retain, and motivate qualified employees, and
encourages them to devote their best efforts to our business and financial
success. An increase in the number of shares available for issuance under the
stock option plan is necessary to meet these objectives. The Board of Directors
believes that approval of Proposal 3 is in the best interests of Neose and its
stockholders.

     The material features of the stock option plan are described below.
Approval of the proposal to amend the Amended and Restated 1995 Stock
Option/Stock Issuance Plan requires the affirmative vote of the holders of a
majority of shares present in person or represented by proxy at the Annual
Meeting.

     The Board of Directors recommends a vote "FOR" the proposal to amend the
stock option plan.

Description of the Stock Option Plan

     We adopted the stock option plan in 1995, and most recently amended the
stock option plan on February 12, 2003. We amended the stock option plan to
increase by 825,000 shares the number of shares of common stock authorized under
the plan, the approval of which is the subject of Proposal 3.

     The stock option plan, which provides for a committee of two or more
non-employee directors to act as the plan administrator, is currently
administered by our Compensation Committee. The plan incorporates our two
predecessor stock option plans, the 1991 Stock Option Plan and the 1992 Stock
Option Plan. The stock option plan is divided into four separate components:

     .    The Discretionary Option Grant Program, under which employees,
          non-employee directors (other than the members of the Compensation
          Committee), and consultants may be granted options to purchase shares
          of common stock;
     .    The Stock Issuance Program, under which employees, non-employee
          directors (other than the members of the Compensation Committee), and
          consultants may be issued shares of common stock either through the
          purchase of shares or as a bonus tied to the performance of services;
     .    The Automatic Option Grant Program, under which option grants will
          automatically be made annually to eligible non-employee directors to
          purchase shares of common stock; and
     .    The Director Fee Option Grant Program, under which non-employee
          directors may elect to receive all, or part, of their annual retainer
          fees in the form of a special option grant instead of cash.

                                       25



     As of March 21, 2003, options to purchase 4,172,065 shares of common stock
were outstanding under the stock option plan, and options to purchase 152,160
shares remained available for future grants. Shares of common stock issued or
currently issuable under the stock option plan are covered by registration
statements on Form S-8, which were filed with the Securities and Exchange
Commission on February 15, 1996, September 10, 1997, October 13, 1999, October
11, 2000, November 14, 2001 and August 2, 2002.

  Eligibility

     All employees, non-employee directors, and consultants are eligible to
receive grants under the stock option plan. Non-employee directors are eligible
to receive grants pursuant to the Automatic Option Grant Program and the
Director Fee Option Grant Program, and non-employee directors who do not serve
on the Compensation Committee are eligible to participate in the Discretionary
Option Grant Program and the Stock Issuance Program. As of March 21, 2003, there
were approximately 125 employees and 8 non-employee directors eligible to
participate in the stock option plan. No person may be granted, in any given
year, more than 50% of the total number of shares for which stock options, stock
appreciation rights, and direct stock issuances may be granted over the term of
the stock option plan.

  Discretionary Option Grant Program

     Under the Discretionary Option Grant Program, the Compensation Committee
has complete discretion to determine:

     .    Which eligible individuals are to receive option grants or stock
          appreciation rights;
     .    The time or times when option grants are to be made;
     .    The number of shares subject to, and the vesting schedule for, each
          option grant;
     .    The designation of each stock option as either an incentive or a
          non-qualified stock option;
     .    The maximum term for which each option grant is to remain outstanding,
          which term, for an incentive stock option, may not exceed ten years,
          and for an incentive stock option granted to a person who owns more
          than 10% of the voting power of Neose may not exceed five years; and
     .    The option exercise price, which for a non-qualified stock option may
          not be less than 85% of the fair market value of the stock on the date
          of grant. The exercise price of an incentive stock option must have an
          exercise price of at least 100% of the fair market value on the date
          of grant, provided that the recipient of the option grant does not own
          more than 10% of the voting power of Neose. If the recipient of an
          incentive stock option owns more than 10% of the voting power of
          Neose, the exercise price must be at least 110% of the fair market
          value on the date of grant. The Internal Revenue Code allows an
          optionee to receive incentive stock options only to the extent that
          the aggregate amount of incentive stock options exercisable for the
          first time by an optionee during any calendar year does not exceed
          $100,000. Any stock option that fails to meet the criteria for an
          incentive stock option will be treated as a non-qualified stock
          option.

     The fair market value of the common stock is the closing sale price per
share on the grant date as such price is reported on The Nasdaq Stock Market. If
there is no reported closing sale price on such date, the fair market value is
the closing sale price on the last preceding date for which a quotation exists.
The closing sale price per share of common stock on March 14, 2003 was $6.90.

     The Compensation Committee also has the authority to cancel outstanding
options under the Discretionary Option Grant Program (including options
incorporated from our two predecessor stock option plans) in return for the
grant of new options for the same or different number of option shares, with an
exercise price per share based upon the fair market value of the common stock on
the new grant date. However, under the Company's By-laws, stockholder approval
is required for any such repricing.

                                       26



     Stock appreciation rights may be issued under the Discretionary Option
Grant Program. These stock appreciation rights will allow the holders to
surrender their outstanding options for an appreciation distribution from Neose
equal to the fair market value of the vested shares of common stock subject to
the surrendered option less the aggregate exercise price payable for such
shares. The appreciation distribution may be made in cash or in shares of common
stock.

   Stock Issuance Program

     Under the Stock Issuance Program, the Compensation Committee has complete
discretion to determine:

     .    Which eligible individuals are to receive stock issuances;
     .    The time or times when stock issuances are to be made; and
     .    The number of shares subject to, and the vesting schedule for, each
          stock issuance.

     The Compensation Committee may issue shares of common stock for cash, a
promissory note, or past services rendered. The consideration must be equal in
value to at least 85% of the fair market value of the common stock issued. The
issued shares may be fully and immediately vested, vest in one or more
installments over a period of service, or vest upon the attainment of certain
performance milestones determined by the Compensation Committee.

  Automatic Option Grant Program

     Under the Automatic Option Grant Program, each non-employee director, on
the date first elected or appointed to the Board of Directors, will
automatically be granted an option to purchase 30,000 shares of common stock,
provided such individual has not been previously employed by us. In addition,
upon each annual re-election to the Board, each non-employee director with at
least six months of Board service will automatically be granted an option to
purchase 10,000 shares of common stock.

     All grants under the Automatic Option Grant Program will be made in strict
compliance with the provisions of such programs. Accordingly, the Compensation
Committee does not exercise any administrative discretion with respect to these
automatic options. Each automatic option has a term of ten years, subject to
earlier termination following the director's cessation of service on the Board.
Each automatic option is immediately exercisable. Any shares purchased upon
exercise of the option, however, are subject to repurchase if the director's
service as a non-employee director ceases prior to vesting of the shares. The
30,000 shares subject to each initial automatic option grant will vest in
successive equal, annual installments over the director's initial four-year
period of Board service. The shares subject to each additional automatic option
grant vest upon the director's completion of one year of service on the Board of
Directors, as measured from the grant date. In addition, shares subject to each
outstanding option will vest immediately upon certain changes in the ownership
or control of Neose.

  Director Fee Option Grant Program

     Under the Director Fee Option Grant Program, each non-employee director may
elect to receive all, or part, of his or her annual retainer fee otherwise
payable in cash in the form of a special option grant under the Director Fee
Option Grant Program. An election to receive an option grant in lieu of annual
retainer fees must be filed with us prior to the annual meeting of stockholders.
If an election is filed, the option grant is automatically made on the date of
the annual meeting, and has an exercise price per share equal to one-third of
the fair market value of the common stock on the grant date. The number of
option shares is determined by dividing the amount of the retainer fee applied
to the program by two-thirds of the fair market value of common stock on the
grant date. As a result, the total spread on the option (the fair market value
of the

                                       27



option shares on the grant date less the aggregate exercise price payable for
those shares) is equal to the portion of the retainer fee subject to the
director's election.

     All grants under the Director Fee Option Grant Program will be made in
strict compliance with the provisions of such programs. Accordingly, the
Compensation Committee does not exercise any administrative discretion with
respect to these options. The option becomes exercisable on the date of grant.
The option remains exercisable for such shares until the earlier of the
expiration of the ten-year option term or the end of the three-year period
measured from the date of the director's cessation of Board service.

  Corporate Transactions

     If we are a party to certain corporate transactions (as defined in the
stock option plan), including certain mergers or asset sales, each outstanding
option and unvested stock issuance will, under certain circumstances,
automatically vest in full. Options and stock issuances that do not vest in full
at the time of the acquisition will vest in full if the individual's service is
terminated, whether involuntarily or through a resignation for good reason,
within 18 months following the acquisition. The Compensation Committee may also
accelerate the vesting of options and unvested stock issuances upon a change in
control (as defined in the stock option plan) of Neose or the termination of the
individual's service, whether involuntarily or through a resignation for good
reason, within a specified period following the change in control. Options
currently outstanding under our predecessor stock option plans contain different
provisions for acceleration of vesting in connection with an acquisition of
Neose. Options outstanding under the 1992 Stock Option Plan may, under certain
circumstances, vest in full upon a change in control. Options outstanding under
the 1991 Stock Option Plan do not contain any acceleration of vesting provisions
in connection with a change in control. The Compensation Committee has the
discretion, however, to extend the acceleration of vesting provisions of the
stock option plan to outstanding options under our predecessor stock option
plans.

  Amendment and Termination of the Stock Option Plan

     The Board has complete and exclusive power and authority to amend or modify
the stock option plan in any, or all, respects. No amendment, however, may
adversely affect the rights and obligations of options outstanding at the time
under the stock option plan. In addition, no amendment may adversely affect the
rights of any optionee with respect to common stock issued under the stock
option plan prior to such action, unless the optionee consents to such action.
In addition, the Board may not, without stockholder approval, amend the stock
option plan to:

     .    Increase the maximum number of shares issuable under the stock option
          plan, or the maximum amount of shares for which any one individual
          participating in the stock option plan may be granted stock options,
          stock appreciation rights, and direct stock issuances for any given
          year;
     .    Materially modify the eligibility requirements for participation; or
     .    Otherwise materially increase the benefits accruing to participants.

     The stock option plan will terminate on the earlier of February 28, 2005 or
the date on which all shares available for issuance under the stock option plan
have been issued.

Federal income tax consequences of the stock option plan

     The following discussion summarizes the principal federal income tax
consequences of the stock option plan based on the Internal Revenue Code and its
regulations, and administrative and judicial interpretations. The summary does
not address any foreign, state, or local tax consequences of participation in
the stock option plan.

                                       28



   Non-Qualified Stock Options

     There generally are no federal income tax consequences to an optionee or to
Neose upon the grant of a non-qualified stock option. Upon the exercise of a
non-qualified stock option, an optionee will recognize ordinary compensation
income in an amount equal to the fair market value of the shares at the time of
exercise less the exercise price of the non-qualified stock option. We generally
will be entitled to a corresponding federal income tax deduction. Upon the sale
of shares of common stock that were acquired by the exercise of a non-qualified
stock option, an optionee will recognize a capital gain or loss. The amount of
the capital gain or loss will be equal to the difference between the amount
realized upon the sale of the shares and the optionee's adjusted tax basis in
the shares of common stock. The optionee's adjusted tax basis in the shares of
common stock is equal to the exercise price plus the amount of ordinary income
recognized by the optionee at the time of exercise of the non-qualified stock
option. The tax rate for the capital gain will depend on the length of time the
shares were held by the optionee and other factors.

  Incentive Stock Options

     A recipient of an incentive stock option will not recognize taxable income,
for purposes of the regular income tax, upon either the grant or exercise of the
incentive stock option. Under the regulations of the Internal Revenue Code
governing the alternative minimum tax, however, the exercise of an incentive
stock option generally increases the recipient's alternative minimum taxable
income in the year in which an incentive stock option is exercised. The amount
of the increase is equal to the fair market value of the shares of common stock
acquired upon exercise less the stock option exercise price. Upon a qualifying
disposition of shares acquired upon exercise of an incentive stock option, an
optionee will recognize long-term capital gain or loss, and we will not be
entitled to a corresponding federal income tax deduction. For these purposes, a
qualifying disposition is defined as a disposition of shares at least two years
after the incentive stock option was granted and at least one year after
exercise of the incentive stock option. As a general rule, if an optionee
disposes of the shares acquired upon exercise of an incentive stock option
before satisfying both holding period requirements, the gain recognized on such
a disposition will be taxed to the optionee as ordinary income, and we generally
will be entitled to a corresponding federal income tax deduction. The amount of
ordinary income is the difference between the fair market value of the shares on
the date of exercise and the option exercise price. The gain, if any, in excess
of the amount recognized as ordinary income on such a disqualifying disposition
will be long-term or short-term capital gain, depending upon the length of time
the optionee held the shares prior to the disposition.

  Stock Appreciation Rights

     An optionee will not recognize any income upon the grant of a stock
appreciation right. Upon the exercise of a stock appreciation right, the
optionee will recognize ordinary compensation income in the amount of both the
cash and the fair market value of the shares of common stock received upon such
exercise, and we generally will be entitled to a corresponding federal income
tax deduction. When an optionee sells shares acquired upon the exercise of a
stock appreciation right, the optionee will recognize a capital gain or loss.
The amount of the capital gain or loss will be equal to the difference between
the amount realized on the sale and the amount of ordinary income recognized at
the time of exercise of the stock appreciation right.

  Stock Issuances

     A recipient generally will recognize taxable income upon the grant of a
stock issuance if:

     .    The shares are not subject to a substantial risk of forfeiture; and
     .    There are no restrictions on the transferability of the shares at the
          time of grant.

                                       29



     A recipient of a grant of restricted stock (a stock issuance not meeting
either of the above criteria) normally will not recognize taxable income upon
the grant, and we will not be entitled to a corresponding federal income tax
deduction. When the shares either are transferable or are no longer subject to a
substantial risk of forfeiture, the recipient will recognize ordinary
compensation income, and we generally will be entitled to a corresponding
federal income tax deduction. The amount of the ordinary compensation income
will be equal to the difference between the fair market value of the common
stock at that time and any amount paid for the shares. A recipient may, however,
elect to recognize ordinary compensation income in the year the restricted stock
grant is awarded, and we generally will be entitled to a corresponding federal
income tax deduction. The amount of ordinary compensation income will be equal
to the difference between the fair market value of the common stock at that time
and any amount paid for the shares.

  Payment of Withholding Taxes

     Our obligation to deliver shares of common stock upon the exercise of any
stock option or upon the issuance of any shares is subject to the satisfaction
of all applicable income and employment tax withholding requirements. In some
circumstances, we permit an optionee to remit directly to the appropriate taxing
authority the amount of the optionee's withholding tax obligations.

Plan benefits

     Option grants to our current executive officers and directors to purchase
the following number of shares of common stock have been made under the stock
option plan (including our two predecessor stock option plans) from adoption of
the 1991 Stock Option Plan through March 21, 2003: C. Boyd Clarke - 262,480;
David A. Zopf - 212,498; Robert I. Kriebel - 165,000; Debra J. Poul - 137,500;
George J. Vergis - 250,000; Joseph J. Villafranca - 190,000; A. Brian Davis -
91,166; Marjorie A. Hurley - 117,833; current executive officers as a group -
1,426,477; current non-employee directors as a group - 1,340,306; and all other
employees and consultants as a group - 1,405,282.

     The benefits and amounts that may be received in the future by persons
eligible to participate in the stock option plan are not currently determinable,
except as to those future automatic grants to be awarded to non-employee
directors under the Automatic Option Grant Program.

     The above description is a partial summary of material provisions of our
stock option plan. This summary is qualified in its entirety by reference to the
full text of the plan, as amended and as proposed to be amended, attached as
Appendix B to this proxy statement.

Vote Required and Recommendation

     The affirmative vote of the holders of a majority of the shares represented
in person or by proxy and entitled to vote on this proposal is required for
approval of this proposal.

     The Board of Directors unanimously recommends a vote "FOR" the approval of
the proposed amendment to the Company's Amended and Restated 1995 Stock
Option/Stock Issuance Plan.

                                       30



Equity Compensation Plan Information

         The following table gives information about our common stock that may
be issued upon the exercise of options, warrants and rights under all of our
existing equity compensation plans as of March 21, 2003, including the Amended
and Restated 1995 Stock Option / Stock Issuance Plan. The table does not include
the additional shares requested for issuance under the Amended and Restated 1995
Stock Option/Stock Issuance Plan in this Proposal 3, or the additional shares
requested for issuance under the Employee Stock Purchase Plan in Proposal 4.



                                                                                           Number of Securities
                                                                                          remaining available for
                            Number of Securities             Weighted-average              future issuance under
                              to be issued upon              exercise price of              equity compensation
                           exercise of outstanding         outstanding options,         plans (excluding securities
    Plan Category       options, warrants and rights        warrants and rights         reflected in second column)
    -------------       ----------------------------        -------------------         ---------------------------
                                                                               
Equity
compensation plans
approved by
securityholders                 4,172,065(1)                     $17.14(1)                      152,160(1)

Equity
compensation plans
not approved by
securityholders                   499,186(2)                     $31.62                              --
                                ---------                                                       -------
Total                           4,671,251                        $18.65                         152,160
                                =========                                                       =======


(1)  Does not include rights granted under the Employee Stock Purchase Plan. The
     next scheduled purchase date under the Employee Stock Purchase Plan is July
     31, 2003, for which rights were granted in connection with the 24-month
     offering period that commenced in February 2002.
(2)  Includes option grant to C. Boyd Clarke and options to two consultants,
     each as described in the text below.

Option Grants Under Plans Not Approved by Stockholders

     On March 29, 2002, the Company's board of directors approved a grant to C.
Boyd Clarke in connection with his appointment as President and Chief Executive
officer of a non-qualified stock option to purchase 487,520 shares of common
stock. The option grant to Mr. Clarke is not pursuant to the stock option plan
and has not been submitted to, and is not required to be submitted to, the
stockholders for approval. The option is exercisable for a period of ten years
at a price of $32.05 per share, which was the fair market value of the
underlying stock on the date of grant. The option is subject to a vesting
schedule pursuant to which the options will vest and become exercisable with
respect to 121,880 shares on March 29, 2003, and on a monthly basis thereafter
such that the option will vest and become exercisable with respect to an
aggregate of 93,750, 121,880, 121,880 and 28,130 shares in each of the remainder
of 2003, 2004, 2005 and the first three months of 2006, respectively.

     On December 6, 1995, the Company granted options to two consultants in
connection with services provided to the Company. These options are now fully
vested and exercisable at a price of $13.80 per share with respect to 8,333
shares for one consultant and 3,333 for the other. These options expire on
December 6, 2005.

                                       31



           Proposal 4 -- Amendment to our Employee Stock Purchase Plan

Proposed Amendment

     At the Annual Meeting, a proposal will be presented to the stockholders to
approve and adopt an amendment to our Employee Stock Purchase Plan to increase
by 33,000 shares the number of shares of common stock authorized under the stock
purchase plan. Of the 150,000 shares currently authorized under the stock
purchase plan, 131,561 shares have been issued purchased pursuant to the plan
and, therefore, are no longer available for grant. The stock purchase plan is
intended to be qualified under Internal Revenue Code Section 423. If a plan is
qualified under Section 423, our employees who participate in the plan enjoy
certain tax advantages, as described below. In order for the plan to be
qualified, our stockholders must approve the plan.

     In February 2003, the Board adopted the proposed amendment, subject to
approval by our stockholders. The stock purchase plan allows our employees to
purchase our common stock at a discount, without being subject to tax until they
sell the stock, and without having to pay any brokerage commissions with respect
to the purchases. The purpose of the stock purchase plan is to encourage the
purchase of common stock by our employees, to provide employees with a personal
stake in Neose, and to help us retain our employees. In addition, we believe
that the stock purchase plan encourages employees to devote their best efforts
to our business and financial success. An increase in the number of shares
available for issuance under the stock option plan is necessary to meet these
objectives. The Board of Directors believes that approval of Proposal 4 is in
the best interests of Neose and its stockholders.

     The material features of the stock purchase plan are described below.
Approval of the proposal to amend the Employee Stock Purchase Plan requires the
affirmative vote of the holders of a majority of shares present in person or
represented by proxy at the Annual Meeting.

     The Board of Directors recommends a vote "FOR" the proposal to amend the
stock purchase plan.

Description of the Stock Purchase Plan

     The stock purchase plan provides employees with the right to purchase
shares of our common stock through payroll deduction. Upon approval by
stockholders of the amendment to the plan, a total of 183,000 shares of our
common stock will be available for purchase under the stock purchase plan,
subject to adjustment in the number and price of shares available for purchase
in the event the outstanding shares of common stock are increased or decreased
through stock dividends, recapitalizations, reorganizations, or similar changes.

     The stock purchase plan is administered by a committee of directors
appointed by the board. Subject to the terms of the stock purchase plan, the
committee has authority to interpret the stock purchase plan, prescribe, amend
and rescind rules and regulations relating to it and make all other
determinations deemed necessary or advisable in administering the stock purchase
plan.

  Eligibility

     To be an eligible participant, an employee must be required to work more
than 20 hours per week for more than five months per calendar year in return for
wages as defined in Internal Revenue Code Section 3401(a). Employees may
participate in the stock purchase plan at the beginning of any purchase period
after they have completed at least one month of service.

                                       32



     Any employee who, after purchasing our common stock under the stock
purchase plan, would own 5% or more of the total combined voting power or value
of all classes of our stock or any subsidiary corporation is not eligible to
participate. Ownership of stock is determined in accordance with the provisions
of Section 424(d) of the Internal Revenue Code. In addition, an employee is not
permitted to purchase stock worth more than $25,000 in fair market value in any
calendar year.

  Purchase Period

     Eligible employees may elect to participate in the stock purchase plan
during an offering period, which shall commence as designated by the committee
and shall not exceed twenty-four months. Stock will be available to be purchased
in a series of successive installments, occurring at the end of each purchase
period, during the offering period. Shares of common stock will be deemed to
have been purchased on the last business day of each purchase period. The
purchase price per share will be 85% of the lesser of:

     .    the fair market value per share of our common stock on the first day
          of the applicable offering period; or
     .    the fair market value per share of our common stock on the last day of
          the purchase period.

If any of these dates is not a trading day, then fair market value will be
determined on the next trading day after such date. In no event shall the
maximum number of shares of common stock purchasable per participant on any
purchase date exceed 1,000 shares.

  Purchase Procedures

     An eligible employee who wishes to participate in the stock purchase plan
must execute a stock purchase agreement and complete the enrollment forms
prescribed by the committee. Each participant will have payroll deductions made
from his or her compensation on each regular payday during the time he or she is
a participant in the stock purchase plan. All payroll deductions will be
credited to the participant's account under the stock purchase plan.

     If the total number of shares of common stock for which purchase rights are
exercised on the purchase date exceeds the maximum number of shares of common
stock available, the committee will make a pro rata allocation of shares
available for delivery and distribution. The unapplied account balances will be
credited to participants' accounts for the next succeeding offering or, at the
participant's election, returned to the participant without interest as soon as
practicable following the end of the offering period.

     A participant's payroll deductions under the plan may be any multiple of 1%
of the participant's base salary up to a maximum of 10% (the "Deduction Rate").
The Deduction Rate shall remain in effect throughout the offering period subject
to reduction, at any time, limited to one reduction per purchase period, and the
participant may increase the Deduction Rate prior to the commencement of any new
purchase period.

     A participant may elect to terminate outstanding purchase rights by
providing a termination form to the board or the committee at any time before
the end of the purchase period. All amounts credited to such participant's
account shall be, at the participant's election, paid as soon as practicable
following receipt of the participant's termination form or held for the purchase
of shares on the next purchase date, and no further payroll deductions will be
made with respect to the participant.

     If a participant's employment terminates for any reason (including death,
disability, or change in status) all amounts credited to such participant's
account will be, at the participant's election, immediately refunded or held for
the purchase of shares on the next purchase date. A participant who is on an
approved leave of absence shall have the election to withdraw all payroll
deductions or have such funds held for the

                                       33



purchase of shares at the end of such purchase period. Upon the participant's
return, his or her payroll deductions under the plan shall automatically resume
at the rate in effect at the time the leave began.

     All funds held or received by us under the stock purchase plan may be used
for any corporate purpose until applied to the purchase of shares of our common
stock or refunded to employees and will not be segregated from our general
assets. Shares of our common stock purchased under the stock purchase plan will
be issued from our authorized but unissued or reacquired common stock. We will
pay all fees and expenses incurred, excluding individual Federal, state, local,
or other taxes, in connection with the stock purchase plan.

     An employee's rights under the stock purchase plan belong to the employee
alone and may not be transferred or assigned to any other person during the
employee's lifetime.

   Corporate Transactions

     Immediately prior to a merger, consolidation, or sale, transfer or other
disposition of all or substantially all of the assets of the corporation
("Corporate Transaction"), all outstanding purchase rights shall automatically
be exercised. The purchase price per share preceding a Corporate Transaction
shall be 85% of the lower of: (a) the fair market value per share of common
stock on the first day of the offering period, or (b) the fair market value per
share of common stock immediately prior to the effective date of such Corporate
Transaction. The corporation shall attempt to provide ten days prior written
notice before the occurrence of any Corporate Transaction, and following the
receipt of such notice, participants may terminate their outstanding purchase
rights.

Federal income tax consequences of the stock purchase plan

     The stock purchase plan is not qualified under Section 401(a) of the
Internal Revenue Code, but is intended to qualify under Section 423 of the
Internal Revenue Code. We generally will not be entitled to a deduction with
respect to stock purchased under the stock purchase plan, unless the stock is
disposed of less than one year after it is purchased by the employee, or less
than two years after the start of the offering period pursuant to which the
stock was purchased.

     Generally, no tax consequences arise at the time the participant purchases
shares of common stock. Upon a disposition of shares, the participant will
receive compensation taxable as ordinary income for the taxable year in which
the disposition occurs in an amount equal to the lesser of:

     .    the excess of the purchase price over the fair market value of the
          shares at the beginning of the offering period, or
     .    the excess over the purchase price of (a) the amount actually received
          for the shares if sold or exchanged or (b) the fair market value of
          the shares on the date of any other termination of his or her
          ownership (such as by gift).

The amount of such ordinary income is then added to the participant's basis in
his shares for purposes of determining capital gain or loss. This tax treatment
only applies if the following holding period requirement is satisfied:

     .    the participant does not dispose of the shares for at least one year
          after the date of purchase, and
     .    the participant does not dispose of the shares for at least two years
          after the beginning of the offering period during which the shares
          were purchased.

     If a participant disposes of shares of common stock purchased under the
stock purchase plan before the holding period is satisfied, he or she will
receive compensation taxable as ordinary income in the amount of the difference
between the amount paid for the shares and the fair market value of the shares
at the time of

                                       34



purchase. If the shares are sold or exchanged, the amount of such ordinar income
is added to the participant's basis in his shares for purposes of determining
capital gain or loss.

     If a participant dies before disposing of the shares purchased under the
stock purchase plan, he or she will be deemed to have realized compensation
income taxable as ordinary income in the taxable year closing with his or her
death in an amount equal to the lesser of:

     .    the excess of the purchase price over the fair market value of the
          shares at the beginning of the offering period, or
     .    the excess of the fair market value of the shares on the date of death
          over the purchase price

  Amendment and Termination of the Stock Purchase Plan

     The committee has the right to amend, modify, or terminate the stock
purchase plan at any time to become effective immediately following close of any
purchase period. However, the committee may not, without the approval of the
corporation's stockholders: (i) materially increase the number of shares of
common stock issuable under the plan or the maximum number of shares purchasable
per participant on any one purchase date, (ii) alter the purchase price formula
so as to reduce the purchase price payable for the shares of common stock
purchasable under the plan, (iii) materially increase the benefits accruing to
participants under the plan or materially modify the requirements for
eligibility to participate in the plan, or (iv) otherwise amend the stock
purchase plan, if such amendment, by law, requires stockholder approval.

Plan benefits

     Our current executive officers have purchased the following number of
shares of common stock under the stock purchase plan since adoption of the
Employee Stock Purchase Plan in 1995 through March 21, 2003: C. Boyd Clarke - 0;
David A. Zopf - 5,661; Robert I. Kriebel - 0; Debra J. Poul - 1,855; George J.
Vergis - 1,443; Joseph J. Villafranca - 0; A. Brian Davis - 3,579; Marjorie A.
Hurley - 3,651; current executive officers as a group--16,189; and all other
employees as a group--115,372. The benefits and amounts that may be received in
the future by persons eligible to participate in the stock purchase plan are not
currently determinable.

     The above description is a partial summary of material provisions of our
stock purchase plan. This summary is qualified in its entirety by reference to
the full text of the plan, as amended and as proposed to be amended, attached as
Appendix C to this proxy statement.

Vote Required and Recommendation

     The affirmative vote of the holders of a majority of the shares represented
in person or by proxy and entitled to vote on this proposal is required for
approval of this proposal.

     The Board of Directors unanimously recommends a vote "FOR" the approval of
the proposed amendment to the Company's Employee Stock Purchase Plan.

                                       35



              Requirements for Advance Notification of Nominations
                            and Stockholder Proposals

  Advance Notice Requirements for next year's Annual Meeting

     Under Section 11 of Article II of our By-Laws, you may nominate a person
for election as a director or propose business to be considered at next year's
Annual Meeting if you:

     .    Are a holder of record at the time of giving the notice described
          below;
     .    Are entitled to vote at next year's Annual Meeting; and
     .    Deliver a written notice of intent to make a nomination or proposal to
          our Corporate Secretary at our offices. You must deliver the written
          notice of intent, which must contain the relevant information
          described below, between November 10, 2003 and December 9, 2003. If
          the date of next year's Annual Meeting is earlier than April 12, 2004
          or later than July 13, 2004, however, your written notice of intent
          must be delivered between the 90th day before next year's Annual
          Meeting and the later of:

          -    The 60th day before next year's Annual Meeting; or
          -    The 10th day after our first public announcement of next year's
               Annual Meeting date.

     If the Board of Directors decides to propose, for next year's Annual
Meeting, an increase in the number of directors, the advance notice requirements
will differ from those described above if we fail to make a timely public
announcement of the proposal. Our public announcement must be made as described
in our By-Laws, and must either name all of the nominees for director or specify
the new size of the Board of Directors. To be considered timely, our first
public announcement of such a proposal must be made:

     .    By March 28, 2004, if the date of next year's Annual Meeting is
          between April 12, 2004 and July 13, 2004; or

     .    By 70 days before next year's Annual Meeting, if the date of next
          year's Annual Meeting is earlier than April 12, 2004 or later than
          July 13, 2004.

     If we fail to meet the applicable deadline for making a timely public
announcement, and you would like to nominate individuals for the new position(s)
created by the increase, you must deliver your written notice of intent by no
later than the 10th day after our first public announcement. Your written notice
of intent may nominate individuals only for new position(s) created by the
increase, and must contain the information described below.

  Requirements for a Written Notice of Intent

     Your written notice of intent to make a nomination or proposal must contain
your name, address, and the number of each class of our shares you own
beneficially and of record. If you are delivering the written notice of intent
on behalf of a beneficial owner of our shares, the written notice of intent also
must contain the beneficial owner's name, address, and the number of each class
of our shares held beneficially and of record. Your written notice of intent
also must include:

     .    As to each person you propose to nominate for election or re-election
          as a director, the nominee's written consent to be named in the proxy
          statement as a nominee and to serve as a director if elected.
     .    As to any other business you propose to bring before the meeting:

                                       36



          -    A brief description of the business;
          -    The reasons for conducting the business at the meeting; and
          -    Your material interest in the business, or the material interest
               in the business of the beneficial owner, if any, on whose behalf
               the proposal is made.

  Other Requirements

     You also must comply with all applicable requirements of the Securities
Exchange Act of 1934 for nominations of directors and proposals of business to
be conducted at stockholder meetings. If you have not complied with the
procedures described above, the chairman of a meeting may refuse to acknowledge
your nomination or proposal. These procedures will not be deemed to affect any
of your rights under Rule 14a-8 under the Securities Exchange Act of 1934 to
request inclusion of proposals in our proxy statements.

                                       37



                                                                      APPENDIX A

                          AMENDED AND RESTATED CHARTER
                             OF THE AUDIT COMMITTEE
                          OF THE BOARD OF DIRECTORS OF
                            NEOSE TECHNOLOGIES, INC.

The Board of Directors (the "Board") of Neose Technologies, Inc. (the "Company")
hereby adopts this Amended and Restated Charter to establish the new governing
principles of the Audit Committee.

1.     Role of the Audit Committee. The role of the Audit Committee is:

       1.1    To act, directly, to fulfill the responsibilities that are
              required of audit committees under the regulations of the
              Securities and Exchange Commission ("SEC") or Nasdaq;

       1.2    To oversee all material aspects of the Company's reporting,
              control and audit functions;

       1.3    To oversee the independence and performance of the Company's
              independent auditors; and

       1.4    To provide a means for open communication between and among the
              Company's independent auditors, financial and senior management,
              the Audit Committee and the Board.

While the Audit Committee has the responsibilities and powers set forth in this
Charter, it is not the duty of the Audit Committee to plan or conduct audits, or
to determine that the Company's financial statements are complete and accurate,
or that they are in accordance with generally accepted accounting principles.
The responsibility to plan and conduct audits is that of the Company's
independent auditors. The Company's management has the responsibility to
determine that the Company's financial statements are complete and accurate and
in accordance with generally accepted accounting principles. It is also not the
duty of the Audit Committee to ensure the Company's compliance with laws and
regulations. The primary responsibility for these matters also rests with the
Company's management.

2.     Composition of the Audit Committee

       2.1    The Board shall designate the members of the Audit Committee at
              each annual organizational meeting of the Board, and the members
              shall serve until the next such meeting or until their successors
              are designated by the Board.

       2.2    All members of the Audit Committee shall be "independent" as that
              term is defined in the regulations of the SEC and Nasdaq. Each
              member of the

                                      A-1



              Audit Committee shall be free of any relationship that, in the
              opinion of the Board, would interfere with his or her exercise of
              independent judgment as an Audit Committee member. All Audit
              Committee members shall have a basic understanding of finance and
              accounting, and shall be able to read and understand financial
              statements at the time of their appointment.

              One member of the Committee shall have accounting or related
              financial management experience, and the Board shall use best
              efforts to assure that one member of the Audit Committee is a
              "financial expert" as that term is defined by SEC rulemaking. In
              addition, the members of the Audit Committee shall meet any other
              requirements of the applicable regulations of the SEC and Nasdaq.

3.     Meetings of the Audit Committee. The Audit Committee shall meet at least
       four times annually, and more frequently as circumstances require. The
       Audit Committee, or the Chair of the Audit Committee, shall be
       responsible for meeting with the independent auditors to discuss the
       interim financial statements.

4.     Responsibilities of the Audit Committee. The Audit Committee shall have
       the responsibilities set forth below with respect to:

       4.1    The Company's Risk and Control Environment

              4.1.1   To discuss with the Company's management, independent
                      auditors and financial management the integrity of the
                      Company's financial reporting processes and controls,
                      particularly the controls in areas representing
                      significant financial and business risks; and

              4.1.2   To investigate any matter brought to its attention within
                      the scope of its role and responsibilities.

       4.2    The Company's Independent Auditors

              4.2.1   To appoint, oversee, and authorize the compensation of the
                      Company's independent auditors;

              4.2.2   To have sole authority to hire and fire the Company's
                      independent auditors;

              4.2.3   To approve in advance any audit or non-audit services
                      provided by the Company's outside auditors;

              4.2.4   To actively engage in a dialogue with the independent
                      auditors about any relationships between the independent
                      auditors and the Company or any services that the
                      independent auditors provide or propose to provide that
                      may impact upon the objectivity and independence of the
                      independent auditors, and to take any appropriate action
                      to oversee the independence of the independent
                      accountants;

                                      A-2



              4.2.5   To have a constructive and positive working relationship
                      with the Company's independent auditors because of the
                      ultimate responsibility of the independent auditors to the
                      Audit Committee, as representatives of the shareholders;

              4.2.6   To be available to the independent auditors at all times,
                      and to provide sufficient opportunity for the independent
                      auditors to meet with members of the Audit Committee
                      without members of management present, to discuss, among
                      other things, the independent auditors' evaluation of the
                      Company's financial and accounting personnel, and the
                      cooperation that the independent auditors received during
                      the course of each audit;

              4.2.7   To ensure that the Audit Committee receives annually from
                      the Company's independent auditors the information about
                      all of the relationships between the independent auditors
                      and the Company that the independent auditors are required
                      to provide to the Audit Committee;

              4.2.8   To discuss with the independent auditors their qualitative
                      judgments about the appropriateness, not just the
                      acceptability, of the accounting principles and financial
                      disclosure practices used or proposed to be adopted by the
                      Company, particularly about the degree of aggressiveness
                      or conservatism of the Company's accounting principles and
                      underlying estimates; and

              4.2.9   To evaluate annually the effectiveness and objectivity of
                      the Company's independent auditors.

       4.3    The Company's Financial Reporting Process

              4.3.1   To oversee the Company's selection of and changes to its
                      accounting policies;

              4.3.2   To meet with the Company's independent auditors and
                      financial management, both to discuss the proposed scope
                      of the audit and to discuss the conclusions of the audit,
                      including any items that the independent auditors are
                      required by generally accepted auditing standards to
                      discuss with the Audit Committee, such as any significant
                      changes to the Company's accounting policies, the
                      integrity of the Company's financial reporting processes,
                      and any proposed changes or improvements in financial,
                      accounting or auditing practices;

              4.3.3   To review with the independent auditors and the Company's
                      financial management the adequacy and effectiveness of the
                      accounting and financial controls of the Company, and to
                      elicit any recommendations for the improvement of such
                      internal control

                                      A-3



                      procedures or particular areas where new or more detailed
                      controls or procedures may be desirable;

              4.3.4   To discuss with the Company's financial management and
                      independent auditors the Company's annual results and
                      interim results before they are made public;

              4.3.5   To review and discuss with the Company's financial
                      management and independent auditors the Company's audited
                      financial statements and interim financial statements
                      before they are made public; and

              4.3.6   To issue for public disclosure by the Company the report
                      required by the rules of the SEC.

       4.4    Other Matters

              4.4.1   To establish and review adherence to the Company's cash
                      management and investment policies;

              4.4.2   To review and approve all of the Company's related-party
                      transactions;

              4.4.3   To establish and maintain in place a mechanism for the
                      confidential and anonymous submission by Company employees
                      of complaints or concerns regarding the Company's
                      accounting practices, and procedures for the receipt and
                      treatment of such complaints or concerns;

              4.4.4   To adopt clear guidelines for the Company's hiring of any
                      employees of the independent auditors who were previously
                      engaged on the Company's account;

              4.4.5   To review and reassess the adequacy of this Charter on an
                      annual basis;

              4.4.6   To report to the Board the matters discussed at each
                      meeting of the Audit Committee; and

              4.4.7   To retain, at the Company's expense, special legal,
                      accounting or other consultants or experts that the Audit
                      Committee deems necessary in the performance of its
                      duties.

5.     Compensation of Audit Committee

       5.1    Each member of the Audit Committee shall be compensated by the
              Company for his or her Board and Committee service, in the manner
              and at the rates established from time to time by the Board.

                                      A-4



5.2    The Company shall not provide any direct compensation for Audit Committee
       members except for their Board and Committee service, as authorized in
       Section 5.1.

                                      A-5



                                                                      Appendix B

                            NEOSE TECHNOLOGIES, INC.
                      1995 STOCK OPTION/STOCK ISSUANCE PLAN
                    (Amended and Restated as of May 13, 2003)


                                   ARTICLE ONE

                                     GENERAL

I.    PURPOSE OF THE PLAN

      A.   This 1995 Stock Option/Stock Issuance Plan (the "Plan") is intended
to promote the interests of Neose Technologies, Inc., a Delaware corporation
(the "Corporation"), by providing eligible individuals with the opportunity to
obtain an equity interest, or otherwise increase their equity interest, in the
Corporation. This Plan shall serve as the successor equity incentive program to
the Corporation's 1992 Stock Option Plan and 1991 Stock Option Plan.

      B.   The Discretionary Option Grant and Stock Issuance Programs of the
Plan became effective immediately upon the adoption of the Plan by the
Corporation's Board of Directors. Such date is hereby designated the "Plan
Effective Date." The Automatic Option Grant Program became effective upon the
execution and final pricing of the Underwriting Agreement for the initial public
offering of the Corporation's Common Stock. The execution date of such
Underwriting Agreement is hereby designated as the Automatic Option Program
Effective Date. The Director Fee Option Grant Program became effective on March
16, 1996.

II.   DEFINITIONS

      A.   For the purposes of this Plan, the following definitions shall be in
effect:

           Board: the Corporation's Board of Directors.

           Change in Control: a change in ownership or control of the
Corporation effected through either of the following transactions:

           --  the direct or indirect acquisition by any person or related group
of persons (other than the Corporation or a person that directly or indirectly
controls, is controlled by, or is under common control with, the Corporation) of
beneficial ownership (within the meaning of Rule 13d-3 of the 1934 Act) of
securities possessing more than fifty percent (50%) of the total combined voting
power of the Corporation's outstanding securities pursuant to a tender or
exchange offer made directly to the Corporation's shareholders which the Board
does not recommend such shareholders to accept, or

           --  a change in the composition of the Board over a period of
thirty-six (36) months or less such that a majority of the Board members ceases,
by reason of one or more

                                      B-1



contested elections for Board membership, to be comprised of individuals who
either (a) have been Board members continuously since the beginning of such
period or (b) have been elected or nominated for election as Board members
during such period by at least a majority of the Board members described in
clause (a) who were still in office at the time such election or nomination was
approved by the Board.

           Code: the Internal Revenue Code of 1986, as amended.

           Committee: the committee of two (2) or more Board members appointed
by the Board to administer and interpret the Plan. The Committee members shall
be "outside directors" as defined under Code Section 162(m) and related Treasury
Regulations and may be "non-employee" Board members as defined under Rule 16b-3
of the 1934 Act. However, notwithstanding anything in the Plan to the contrary,
the Board must ratify or approve any grants made under the Discretionary Option
Grant Program or Stock Issuance Program to any Board members or officers of the
Corporation. References in the Plan to the Committee shall be deemed to include
the Board, with respect to ratification or approval of grants made to Board
members and officers of the Corporation. In addition, the Board may appoint a
"Non-Section 16(b) Committee" solely for the purpose of making grants under the
Discretionary Option Grant Program to individuals who are not covered by Section
16 of the 1934 Act. Such Committee shall have no powers other than the power to
make grants to such individuals. Any reference to "Committee" herein shall also
encompass the Non-Section 16(b) Committee where appropriate.

           Common Stock: shares of the Corporation's common stock.

           Corporate Transaction: either of the following shareholder-approved
transactions to which the Corporation is a party:

               (i)   a merger or consolidation in which securities possessing
more than fifty percent (50%) of the total combined voting power of the
Corporation's outstanding securities are transferred to a person or persons
different from the persons holding those securities immediately prior to such
transaction, or

               (ii)  the sale, transfer or other disposition of all or
substantially all of the Corporation's assets in complete liquidation or
dissolution of the Corporation.

           Employee: an individual who performs services while in the employ of
the Corporation or one or more parent or subsidiary corporations, subject to the
control and direction of the employer entity not only as to the work to be
performed but also as to the manner and method of performance.

           Exercise Date: the date on which the Corporation shall have written
notice of the option exercise.

           Fair Market Value: the Fair Market Value per share of Common Stock
determined in accordance with the following provisions:

           --  If the Common Stock is at the time traded on the Nasdaq National
Market, the Fair Market Value shall be the closing selling price per share on
the date in question, as such

                                      B-2



price is reported by the National Association of Securities Dealers on the
Nasdaq National Market or any successor system. If there is no reported closing
selling price for the Common Stock on the date in question, then the Fair Market
Value shall be the closing selling price on the last preceding date for which
such quotation exists.

           --  If the Common Stock is at the time listed or admitted to trading
on any national securities exchange, then the Fair Market Value shall be the
closing selling price per share on the date in question on the exchange
determined by the Plan Administrator to be the primary market for the Common
Stock, as such price is officially quoted in the composite tape of transactions
on such exchange. If there is no reported sale of Common Stock on such exchange
on the date in question, then the Fair Market Value shall be the closing selling
price on the exchange on the last preceding date for which such quotation
exists.

           --  If the Common Stock is on the date in question neither listed nor
admitted to trading on any national securities exchange nor traded on the Nasdaq
National Market, then the Fair Market Value of the Common Stock on such date
shall be determined by the Plan Administrator after taking into account such
factors as the Plan Administrator shall deem appropriate.

           Hostile Take-Over: a change in ownership of the Corporation effected
through the following transaction:

           --  the direct or indirect acquisition by any person or related group
of persons (other than the Corporation or a person that directly or indirectly
controls, is controlled by, or is under common control with, the Corporation) of
beneficial ownership (within the meaning of Rule 13d-3 of the 1934 Act) of
securities possessing more than fifty percent (50%) of the total combined voting
power of the Corporation's outstanding securities pursuant to a tender or
exchange offer made directly to the Corporation's shareholder's which the Board
does not recommend such shareholders to accept, and

           --  the acceptance of more than fifty percent (50%) of the securities
so acquired in such tender or exchange offer from holders other than the
officers and directors of the Corporation subject to the short-swing profit
restrictions of Section 16 of the 1934 Act.

           Incentive Option: a stock option which satisfies the requirements of
Code Section 422.

           Involuntary Termination: the termination of the Service of any
Optionee or Participant which occurs by reason of:

           --  such individual's voluntary resignation following (A) a change in
his or her position with the Corporation which materially reduces his or her
level of responsibility, (B) a reduction in his or her level of compensation
(including base salary, fringe benefits and any non-discretionary and
objective-standard incentive payment or bonus award) by more than ten percent
(10%) in the aggregate or (C) a relocation of such individual's place of
employment by more than fifty (50) miles, provided and only if such change,
reduction or relocation is effected by the Corporation without the individual's
consent.

                                      B-3



           Misconduct: the commission of any act of fraud, embezzlement or
dishonesty by the Optionee or Participant, any unauthorized use or disclosure by
such individual of confidential information or trade secrets of the Corporation
or its parent or subsidiary corporations, any failure to perform specific lawful
direction of the Corporation's Board or officers of the Corporation, any refusal
or neglect to perform such individual's duties, any conviction of, or entering
of a plea of nolo contendre to, a crime which constitutes a felony or any other
Misconduct by such individual adversely affecting the business or affairs of the
Corporation. The foregoing definition shall not be deemed to be inclusive of all
the acts or omissions which the Corporation or any parent or subsidiary may
consider as grounds for the dismissal or discharge of any Optionee, Participant
or other individual in the Service of the Corporation.

           1934 Act: the Securities Exchange Act of 1934, as amended.

           Non-Statutory Option: a stock option not intended to meet the
requirements of Code Section 422.

           Optionee: a person to whom an option is granted under the
Discretionary Option Grant Program, the Automatic Option Grant Program or the
Director Fee Option Grant Program.

           Participant: a person who is issued Common Stock under the Stock
Issuance Program.

           Permanent Disability: the inability of an individual to engage in any
substantial gainful activity, by reason of any medically determinable physical
or mental impairment which is expected to result in death or which has lasted or
can be expected to last for a period of not less than twelve (12) months.

           Plan Administrator: either the Board or the Committee, to the extent
the Committee is at the time responsible for the administration of the Plan in
accordance with Section IV of Article One.

           Predecessor Plans: the Corporation's 1992 Stock Option Plan and 1991
Stock Option Plan.

           Service: the performance of services on a periodic basis for the
Corporation (or any parent or subsidiary corporation) in the capacity of an
Employee, a non-employee member of the board of directors or an independent
consultant, except to the extent otherwise specifically provided in the
applicable stock option or stock issuance agreement.

           Section 12(g) Registration Date: the date on which the initial
registration of the Common Stock under Section 12(g) of the 1934 Act became
effective.

           Take-Over Price: the greater of (a) the Fair Market Value per share
of Common Stock on the date the particular option to purchase such stock is
surrendered to the Corporation in connection with a Hostile Take-Over or (b) the
highest reported price per share of Common Stock paid by the tender offeror in
effecting such Hostile Take-Over. However, if the canceled option is an
Incentive Option, then the Take-Over Price shall not exceed the clause (a) price
per share.

                                      B-4



           10% Shareholder: the owner of stock (as determined under Code Section
424(d)) possessing ten (10%) percent or more of the total combined voting power
of all classes of stock of the Corporation or any parent or subsidiary
corporation.

      B.   The following provisions shall be applicable in determining the
parent and subsidiary corporations of the Corporation:

               Any corporation (other than the Corporation) in an unbroken chain
           of corporations ending with the Corporation shall be considered to be
           a parent of the Corporation, provided each such corporation in the
           unbroken chain (other than the Corporation) owns, at the time of the
           determination, stock possessing fifty percent (50%) or more of the
           total combined voting power of all classes or stock in one of the
           other corporations in such chain.

               Each corporation (other than the Corporation) in an unbroken
           chain of corporations beginning with the Corporation shall be
           considered to be a subsidiary of the Corporation, provided each such
           corporation (other than the last corporation) in the unbroken chain
           owns, at the time of the determination, stock possessing fifty
           percent (50%) or more of the total combined voting power of all
           classes of stock in one of the other corporations in such chain.

III.  STRUCTURE OF THE PLAN

      A.   The Plan shall be divided into four separate components: the
Discretionary Option Grant Program specified in Article Two, the Stock Issuance
Program specified in Article Three, the Automatic Option Grant Program specified
in Article Four and the Director Fee Option Grant Program specified in Article
Five. Under the Discretionary Option Grant Program, eligible individuals may at
the discretion of the Plan Administrator be granted options to purchase shares
of Common Stock in accordance with the provisions of Article Two at a price not
less than eighty-five percent (85%) of the Fair Market Value of such shares on
the grant date. Under the Stock Issuance Program, eligible individuals may be
issued shares of Common Stock directly, either through the immediate purchase of
the shares (at Fair Market Value or at discounts of up to 15%) or as a bonus
tied to the individual's performance of services or the Corporation's attainment
of prescribed milestones. Under the Automatic Option Grant Program, each
individual serving as a non-employee Board member on the Automatic Option Grant
Program Effective Date and each individual who first joins the Board as a
non-employee director at any time after such Effective Date shall at periodic
intervals receive option grants to purchase shares of Common Stock in accordance
with the provisions of Article Four, with the first such grants to be made on
such Effective Date. Under the Director Fee Option Grant Program, each
non-employee Board member may elect to apply all or a portion of his or her
annual retainer fee otherwise payable in cash to a special below market option
grant.

      B.   Unless the context clearly indicates otherwise, the provisions of
Articles One and Six shall apply to all equity programs under the Plan and shall
accordingly govern the interests of all individuals under the Plan.

                                      B-5



IV.   ADMINISTRATION OF THE PLAN

      A.   The Discretionary Option Grant and Stock Issuance Programs shall be
administered solely and exclusively by the Committee, subject to such conditions
and limitations as the Board may decide, to the extent permissible under
applicable securities and tax laws requirements.

      B.   Members of the Committee shall serve for such period of time as the
Board may determine and shall be subject to removal by the Board at any time.

      C.   The Plan Administrator shall have full power and authority (subject
to the express provisions of the Plan) to establish rules and regulations for
the proper administration of the Discretionary Option Grant and Stock Issuance
Programs and to make such determinations under, and issue such interpretations
of, the provisions of such programs and any outstanding option grants or stock
issuances thereunder as it may deem necessary or advisable. Decisions of the
Plan Administrator shall be final and binding on all parties who have an
interest in the Discretionary Option Grant or Stock Issuance Program or any
outstanding option grant or share issuance thereunder.

      D.   Administration of the Automatic Option Grant and Director Fee Option
Grant Programs shall be self-executing in accordance with the express terms and
conditions of those programs, and the Plan Administrator shall exercise no
discretionary functions with respect to option grants made pursuant to those
programs.

V.    OPTION GRANTS AND STOCK ISSUANCES

      A.   The persons eligible to participate in the Discretionary Option Grant
Program under Article Two and the Stock Issuance Program under Article Three
shall be limited to the following

               (i)   officers and other employees of the Corporation (or any
parent or subsidiary corporation);

               (ii)  non-employee members of the Board or the non-employee
members of the board of directors of any parent or subsidiary corporation; and

               (iii) consultants who provide valuable services to the
Corporation (or any parent or subsidiary corporation); provided such services
are not in connection with the offer or sale of securities in a capital-raising
transaction.

      B.   The Plan Administrator shall have full authority to determine, (i)
with respect to the option grants made under the Discretionary Option Grant
Program, which eligible individuals are to receive option grants, the time or
times when such grants are to be made, the number of shares to be covered by
each such grant, the status of the granted option as either an Incentive Option
or a Non-Statutory Option, the time or times at which each granted option is to
become exercisable and the maximum term for which the option may remain
outstanding, and (ii) with respect to stock issuances under the Stock Issuance
Program, the number of shares to be issued

                                       B-6



to each Participant, the vesting schedule (if any) to be applicable to the
issued shares, and the consideration to be paid by the Participant for such
shares.

VI.   STOCK SUBJECT TO THE PLAN

      A.   Shares of Common Stock shall be available for issuance under the Plan
and shall be drawn from either the Corporation's authorized but unissued shares
of Common Stock or from reacquired shares of Common Stock, including shares
repurchased by the Corporation on the open market. The maximum number of shares
of Common Stock which may be issued over the term of the Plan shall not exceed
5,876,666* shares, subject to adjustment from time to time in accordance with
the provisions of this Section VI. Such authorized share reserve is comprised of
(i) the number of shares which remained for issuance, as of the Plan Effective
Date, under the Predecessor Plans as last approved by the Corporation's
shareholders, including the shares subject to the outstanding options
incorporated into this Plan and any other shares which would have been available
for future option grant under the Predecessor Plans as last approved by the
shareholders, plus (ii) an additional increase of 333,333* shares authorized by
the Board on the Plan Effective Date, (iii) an additional increase of 600,000*
shares authorized by the Board on December 6, 1995, (iv) an additional increase
of 500,000 shares authorized by the Board on March 19, 1997, (v) an additional
increase of 495,000 shares authorized by the Board on April 16, 1999, (vi) an
additional increase of 690,000 shares authorized by the Board on April 17, 2000,
(vii) an additional increase of 700,000 shares authorized by the Board on March
21, 2001, (viii) an additional increase of 1,150,000 shares authorized by the
Board on April 10, 2002, and (ix) an additional increase of 825,000 shares
authorized by the Board on February 12, 2003. As one or more outstanding options
under the Plan are exercised, the number of shares issued with respect to each
such option shall reduce, on a share-for-share basis, the number of shares
available for issuance under this Plan.

      B.   In no event shall the aggregate number of shares of Common Stock for
which any one individual participating in the Plan may be granted stock options,
separately exercisable stock appreciation rights and direct stock issuances for
any given year exceed fifty percent (50%) of the total number of shares for
which stock options, separately exercisable stock appreciation rights and direct
stock issuances may be granted over the term of the Plan.

      C.   Should one or more outstanding options under this Plan (including
options incorporated from the Predecessor Plans) expire or terminate for any
reason prior to exercise in full (including any option canceled in accordance
with the cancellation-regrant provisions of Section IV of Article Two of the
Plan), then the shares subject to the portion of each option not so exercised
shall be available for subsequent issuance under the Plan. Shares subject to any
stock appreciation rights exercised under the Plan and all share issuances under
the Plan, whether or not the shares are subsequently repurchased by the
Corporation pursuant to its repurchase rights under the Plan, shall reduce on a
share-for-share basis the number of shares of Common Stock available for
subsequent issuance under the Plan. In addition, should the exercise price of an
outstanding option under the Plan be paid with shares of Common Stock or should
shares of

------------------------
*     Reflects the 1-for-3 stock split that was effected immediately prior to
the consummation of the initial public offering of the Common Stock.

                                      B-7



Common Stock otherwise issuable under the Plan be withheld by the Corporation in
satisfaction of the withholding taxes incurred in connection with the exercise
of an outstanding option under the Plan or the vesting of a direct share
issuance made under the Plan, then the number of shares of Common Stock
available for issuance under the Plan shall be reduced by the gross number of
shares for which the option is exercised or which vest under the share issuance,
and not by the net number of shares of Common Stock actually issued to the
holder of such option or share issuance.

     D.   Should any change be made to the Common Stock issuable under the Plan
by reason of any stock split, stock dividend, recapitalization, combination of
shares, exchange of shares or other change affecting the outstanding Common
Stock as a class without the Corporation's receipt of consideration, then
appropriate adjustments shall be made to (i) the maximum number and/or class of
securities issuable under the Plan, (ii) the maximum amount and/or class of
securities for which any one individual participating in the Plan may be granted
stock options, separately exercisable stock appreciation rights and direct stock
issuances for any given year under the Plan, (iii) the number and/or class of
securities for which automatic option grants are to be subsequently made per
eligible non-employee Board member under the Automatic Option Grant Program,
(iv) the number and/or class of securities and price per share in effect under
each option outstanding under the Discretionary Option Grant, Automatic Option
Grant or Director Fee Option Grant Program and (v) the number and/or class of
securities and price per share in effect under each outstanding option
incorporated into this Plan from the Predecessor Plans. Such adjustments to the
outstanding options are to be effected in a manner which shall preclude the
enlargement or dilution of rights and benefits under such options. The
adjustments determined by the Plan Administrator shall be final, binding and
conclusive.

                                   ARTICLE TWO

                       DISCRETIONARY OPTION GRANT PROGRAM

I.   TERMS AND CONDITIONS OF OPTIONS

          Options granted pursuant to the Discretionary Option Grant Program
shall be authorized by action of the Plan Administrator and may, at the Plan
Administrator's discretion, be either Incentive Options or Non-Statutory
Options. Individuals who are not Employees of the Corporation or its parent or
subsidiary corporations may only be granted Non-Statutory Options. Each granted
option shall be evidenced by one or more instruments in the form approved by the
Plan Administrator; provided, however, that each such instrument shall comply
with the terms and conditions specified below. Each instrument evidencing an
Incentive Option shall, in addition, be subject to the applicable provisions of
Section II of this Article Two.

     A.   Exercise Price.

          1.   The exercise price per share shall be fixed by the Plan
Administrator in accordance with the following provisions:

                                       B-8



               (i)   The exercise price per share of Common Stock subject to an
Incentive Option shall in no event be less than one hundred percent (100%) of
the Fair Market Value of such Common Stock on the grant date.

               (ii)  The exercise price per share of Common Stock subject to a
Non-Statutory Option shall in no event be less than eighty-five percent (85%) of
the Fair Market Value of such Common Stock on the grant date.

               (iii) If any individual to whom an Incentive Option is granted is
a 10% Shareholder, then the exercise price per share shall not be less than one
hundred ten percent (110%) of the Fair Market Value per share of Common Stock on
the grant date.

          2.   The exercise price shall become immediately due upon exercise of
the option and shall, subject to the provisions of Section I of Article Six, be
payable in one or more of the forms specified below:

               (i)   cash or check made payable to the Corporation,

               (ii)  in shares of Common Stock held by the Optionee for the
requisite period necessary to avoid a charge to the Corporation's earnings for
financial reporting purposes and valued at Fair Market Value on the Exercise
Date, or

               (iii) to the extent the option is exercised for vested shares,
through a special sale and remittance procedure pursuant to which the Optionee
shall concurrently provide irrevocable written instructions (a) to a
Corporation-designated brokerage firm to effect the immediate sale of the
purchased shares and remit to the Corporation, out of the sale proceeds
available on the settlement date, sufficient funds to cover the aggregate
exercise price payable for the purchased shares plus all applicable Federal,
state and local income and employment taxes required to be withheld by the
Corporation by reason of such purchase and (b) to the Corporation to deliver the
certificates for the purchased shares directly to such brokerage firm in order
to complete the sale transaction.

          3.   Except to the extent such sale and remittance procedure is
utilized, payment of the exercise price for the purchased shares must be made on
the Exercise Date.

     B.   Term and Exercise of Options. Each option granted under this Plan
shall be exercisable at such time or times and during such period as is
determined by the Plan Administrator and set forth in the instrument evidencing
the grant. No such option, however, shall have a maximum term in excess of ten
(10) years measured from the grant date.

          1.   During the lifetime of the Optionee, the option, together with
any related stock appreciation right, shall be exercisable only by the Optionee
and shall not be assignable or transferable by the Optionee, except for a
transfer of the option by will or by the laws of descent and distribution
following the Optionee's death or, with respect to options other than Incentive
Options, if permitted in any specific case by the Plan Administrator, pursuant
to a domestic relations order (as defined under the Code or Treasury
Regulations).

                                       B-9



          2.   Notwithstanding the foregoing, the Plan Administrator may provide
that an Optionee may transfer Non-Statutory Options to family members or other
persons or entities according to such terms as the Plan Administrator may
determine; provided that the Optionee receives no consideration for the transfer
of an option and the transferred option shall continue to be subject to the same
terms and conditions as were applicable to the option immediately before the
transfer.

     C.   Termination of Service.

          1.   Except to the extent otherwise provided pursuant to subsection
C.2 below, the following provisions shall govern the exercise period applicable
to any options held by the Optionee at the time of cessation of Service or
death:

               (i)   Should the Optionee cease to remain in Service for any
reason other than death, Permanent Disability or Misconduct, then the period
during which each outstanding option held by such Optionee is to remain
exercisable shall be limited to the three (3)-month period following the date of
such cessation of Service.

               (ii)  Should the Optionee's Service terminate by reason of
Permanent Disability, then the period during which each outstanding option held
by the Optionee is to remain exercisable shall be limited to the twelve
(12)-month period following the date of such cessation of Service.

               (iii) Should the Optionee die while holding one or more
outstanding options, then the period during which each such option is to remain
exercisable shall be limited to the twelve (12)-month period following the date
of the Optionee's death. During such limited period, the option may be exercised
by the personal representative of the Optionee's estate or by the person or
persons to whom the option is transferred pursuant to the Optionee's will or in
accordance with the laws of descent and distribution.

               (iv)  Should the Optionee's Service be terminated for Misconduct,
then all outstanding options held by the Optionee shall terminate immediately
and cease to be outstanding.

               (v)   Under no circumstances, however, shall any such option be
exercisable after the specified expiration date of the option term.

               (vi)  During the applicable post-Service exercise period, the
option may not be exercised in the aggregate for more than the number of vested
shares for which the option is exercisable on the date of the Optionee's
cessation of Service. Upon the expiration of the applicable exercise period or
(if earlier) upon the expiration of the option term, the option shall terminate
and cease to be exercisable for any vested shares for which the option has not
been exercised. However, the option shall, immediately upon the Optionee's
cessation of Service, terminate and cease to be outstanding with respect to any
option shares for which the option is not at that time exercisable or in which
the Optionee is not otherwise at that time vested.

          2.   The Plan Administrator shall have complete discretion,
exercisable either at the time the option is granted or at any time while the
option remains outstanding,

                                      B-10



               -     to extend the period of time for which the option is to
          remain exercisable following the Optionee's cessation of Service or
          death from the limited period in effect under subsection C.1 of this
          Section I of Article Two to such greater period of time as the Plan
          Administrator shall deem appropriate; provided that in no event shall
          such option be exercisable after the specified expiration date of the
          option term; and/or

               -     to permit one or more options held by the Optionee under
          this Article Two to be exercised, during the limited post-Service
          exercise period applicable under this paragraph C, not only with
          respect to the number of vested shares of Common Stock for which each
          such option is exercisable at the time of the Optionee's cessation of
          Service but also with respect to one or more subsequent installments
          for which the option would otherwise have become exercisable had such
          cessation of Service not occurred.

     D.   Shareholder Rights. An Optionee shall have no shareholder rights with
respect to any shares covered by the option until such individual shall have
exercised the option and paid the exercise price for the purchased shares.

     E.   Unvested Shares. The Plan Administrator shall have the discretion to
authorize the issuance of unvested shares of Common Stock under the Plan. Should
the Optionee cease Service while holding such unvested shares, the Corporation
shall have the right to repurchase, at the exercise price paid per share, any or
all of those unvested shares. The terms and conditions upon which such
repurchase right shall be exercisable (including the period and procedure for
exercise and the appropriate vesting schedule for the purchased shares) shall be
established by the Plan Administrator and set forth in the agreement evidencing
such repurchase right. All outstanding repurchase rights under the Plan shall
terminate automatically upon the occurrence of any Corporate Transaction, except
to the extent the repurchase rights are expressly assigned to the successor
corporation (or parent thereof) in connection with the Corporate Transaction.

II.  INCENTIVE OPTIONS

          Incentive Options may only be granted to individuals who are
Employees, and the terms and conditions specified below shall be applicable to
all Incentive Options granted under the Plan. Except as modified by the
provisions of this Section II, all the provisions of Articles One, Two and Six
of the Plan shall be applicable to all Incentive Options granted hereunder. Any
Options specifically designated as Non-Statutory shall not be subject to the
terms and conditions of this Section II.

     A.   Dollar Limitation. The aggregate Fair Market Value (determined as of
the respective date or dates of grant) of the Common Stock for which one or more
options granted to any Employee under this Plan (or any other option plan of the
Corporation or its parent or subsidiary corporations) may for the first time
become exercisable as incentive stock options under the Federal tax laws during
any one calendar year shall not exceed the sum of One Hundred Thousand Dollars
($100,000). To the extent the Employee holds two (2) or more such options which
become exercisable for the first time in the same calendar year, the foregoing
limitation on the exercisability of such options as incentive stock options
under the Federal tax

                                      B-11



laws shall be applied on the basis of the order in which such options are
granted. Should the number of shares of Common Stock for which any Incentive
Option first becomes exercisable in any calendar year exceed the applicable One
Hundred Thousand Dollar ($100,000) limitation, then that option may nevertheless
be exercised in that calendar year for the excess number of shares as a
Non-Statutory Option under the Federal tax laws.

     B.   10% Shareholder. If any individual to whom an Incentive Option is
granted is a 10% Shareholder, then the option term shall not exceed five (5)
years measured from the grant date.

III. CORPORATE TRANSACTION/CHANGE IN CONTROL

     A.   In the event of any Corporate Transaction, each option which is at the
time outstanding under this Article Two shall automatically accelerate so that
each such option shall, immediately prior to the specified effective date for
such Corporate Transaction, become fully exercisable with respect to the total
number of shares of Common Stock at the time subject to such option and may be
exercised for all or any portion of such shares as fully-vested shares. However,
an outstanding option under this Article Two shall not so accelerate if and to
the extent: (i) such option is, in connection with such Corporate Transaction,
either to be assumed by the successor corporation or parent thereof or to be
replaced with a comparable option to purchase shares of the capital stock of the
successor corporation or parent thereof, (ii) such option is to be replaced with
a cash incentive program of the successor corporation which preserves the option
spread existing at the time of such Corporate Transaction and provides for
subsequent payout in accordance with the same vesting schedule applicable to
such option, (iii) such option is to be replaced by another incentive program
which the Plan Administrator determines is reasonably equivalent in value to the
program contemplated by either clause (i) or (ii) above, or (iv) the
acceleration of such option is subject to other limitations imposed by the Plan
Administrator at the time of the option grant. However, upon an Optionee's
cessation of Service by reason of an Involuntary Termination (other than for
Misconduct) within eighteen (18) months after a Corporate Transaction in which
his or her outstanding options are assumed or replaced pursuant to clause (i),
(ii) or (iii) above, each such option under clause (i) shall automatically
accelerate and become fully exercisable with respect to the total number of
shares of Common Stock at the time subject to such option and may be exercised
for all or any portion of such shares as fully-vested shares, the cash incentive
program under clause (ii) shall become fully vested and the benefits under a
clause (iii) replacement program shall become fully vested. The option as so
accelerated shall remain exercisable until the earlier of (i) the expiration of
the option term or (ii) the expiration of a ninety (90)-day period measured from
the date of such Involuntary Termination. The determination of option
comparability under clause (i) or program comparability under clause (iii) above
shall be made by the Plan Administrator, and its determination shall be final,
binding and conclusive.

     B.   Immediately following the consummation of a Corporate Transaction, all
outstanding options under this Article Two shall terminate and cease to remain
outstanding, except to the extent assumed by the successor corporation or its
parent company.

     C.   Each outstanding option under this Article Two that is assumed in
connection with a Corporate Transaction shall be appropriately adjusted,
immediately after such Corporate

                                      B-12



Transaction, to apply and pertain to the number and class of securities which
would have been issued to the option holder in consummation of such Corporate
Transaction had such person exercised the option immediately prior to such
Corporate Transaction. Appropriate adjustments shall also be made to the
exercise price payable per share, provided the aggregate exercise price payable
for such securities shall remain the same. In addition, the class and number of
securities available for issuance under the Plan on both an aggregate and
participant basis following the consummation of such Corporate Transaction shall
be appropriately adjusted.

     D.   The Plan Administrator shall have the discretionary authority,
exercisable either at the time the option is granted or at any time while the
option remains outstanding, to provide for the automatic acceleration of one or
more outstanding options under this Article Two (and the termination of one or
more of the Corporation's outstanding repurchase rights under this Article Two)
upon the occurrence of a Change in Control. The Plan Administrator shall also
have full power and authority to condition any such option acceleration (and the
termination of any outstanding repurchase rights) upon the Optionee's cessation
of Service by reason of an Involuntary Termination (other than for Misconduct)
within a specified period following such Change in Control.

     E.   Any options accelerated in connection with a Change in Control shall
remain fully exercisable until the expiration or sooner termination of the
option term or the surrender of such option in accordance with Section V of this
Article Two.

     F.   The grant of options under this Article Two shall in no way affect the
right of the Corporation to adjust, reclassify, reorganize or otherwise change
its capital or business structure or to merge, consolidate, dissolve, liquidate
or sell or transfer all or any part of its business or assets.

     G.   The portion of any Incentive Option accelerated under this Section III
in connection with a Corporate Transaction or Change in Control shall remain
exercisable as an incentive stock option under the Federal tax laws only to the
extent the dollar limitation of Section II of this Article Two is not exceeded.
To the extent such dollar limitation is exceeded, the accelerated portion of
such option shall be exercisable as a non-statutory option under the Federal tax
laws.

IV. CANCELLATION AND REGRANT OF OPTIONS

          The Plan Administrator shall have the authority to effect, at any time
and from time to time, with the consent of the affected Optionees, the
cancellation of any, or all outstanding options under this Article Two
(including outstanding options under the Predecessor Plans incorporated into
this Plan) and to grant in substitution new options under the Plan covering the
same or different numbers of shares of Common Stock but with an exercise price
per share not less than (i) one hundred percent (100%) of the Fair Market Value
on the new grant date in the case of a grant of an Incentive Option, (ii) one
hundred ten percent (110%) of such Fair Market Value in the case of an Incentive
Option grant to a 10% Shareholder or (iii) eighty-five percent (85%) of such
Fair Market Value in the case of all other grants.

                                      B-13



V.   STOCK APPRECIATION RIGHTS

     A.   Provided and only if the Plan Administrator determines in its
discretion to implement the stock appreciation right provisions of this Section
V, one or more Optionees may be granted the right, exercisable upon such terms
and conditions as the Plan Administrator may establish, to surrender all or part
of an unexercised option under this Article Two in exchange for a distribution
from the Corporation in an amount equal to the excess of (i) the Fair Market
Value (on the option surrender date) of the number of shares in which the
Optionee is at the time vested under the surrendered option (or surrendered
portion thereof) over (ii) the aggregate exercise price payable for such vested
shares.

     B.   No surrender of an option shall be effective hereunder unless it is
approved by the Plan Administrator. If the surrender is so approved, then the
distribution to which the Optionee shall accordingly become entitled under this
Section V may be made in shares of Common Stock valued at Fair Market Value on
the option surrender date, in cash, or partly in shares and partly in cash, as
the Plan Administrator shall in its sole discretion deem appropriate.

     C.   If the surrender of an option is rejected by the Plan Administrator,
then the Optionee shall retain whatever rights the Optionee had under the
surrendered option (or surrendered portion thereof) on the option surrender date
and may exercise such rights at any time prior to the later of (i) five (5)
business days after the receipt of the rejection notice or (ii) the last day on
which the option is otherwise exercisable in accordance with the terms of the
instrument evidencing such option, but in no event may such rights be exercised
more than ten (10) years after the date of the option grant.

     D.   One or more officers of the Corporation subject to the short-swing
profit restrictions of the Federal securities laws may, in the Plan
Administrator's sole discretion, be granted limited stock appreciation rights in
tandem with their outstanding options under this Article Two. Upon the
occurrence of a Hostile Take-Over at a time when the Corporation's outstanding
Common Stock is registered under Section 12(g) of the 1934 Act, each such
officer holding one or more options with such a limited stock appreciation right
in effect for at least six (6) months shall have the unconditional right
(exercisable for a thirty (30)-day period following such Hostile Take-Over) to
surrender each such option to the Corporation, to the extent the option is at
the time exercisable for fully vested shares of Common Stock. The officer shall
in return be entitled to a cash distribution from the Corporation in an amount
equal to the excess of (i) the Take-Over Price of the vested shares of Common
Stock at the time subject to each surrendered option (or surrendered portion of
such option) over (ii) the aggregate exercise price payable for such vested
shares. Such cash distribution shall be made within five (5) days following the
option surrender date. Neither the approval of the Plan Administrator nor the
consent of the Board shall be required in connection with such option surrender
and cash distribution. Any unsurrendered portion of the option shall continue to
remain outstanding and become exercisable in accordance with the terms of the
instrument evidencing such grant.

     E.   The shares of Common Stock subject to any option surrendered for an
appreciation distribution pursuant to this Section V shall not be available for
subsequent issuance under the Plan.

                                      B-14



                                  ARTICLE THREE

                             STOCK ISSUANCE PROGRAM

I.   TERMS AND CONDITIONS OF STOCK ISSUANCES

          Shares of Common Stock may be issued under the Stock Issuance Program
through direct and immediate purchases without any intervening stock option
grants. The issued shares shall be evidenced by a Stock Issuance Agreement
("Issuance Agreement") that complies with the terms and conditions of this
Article Three.

     A.   Consideration.

          1.   Shares of Common Stock may be issued under the Stock Issuance
Program for one or more of the following items of consideration which the Plan
Administrator may deem appropriate in each individual instance:

               (i)   full payment in cash or check made payable to the
Corporation's order;

               (ii)  a promissory note payable to the Corporation's order in one
or more installments; or

               (iii) past services rendered to the Corporation or any parent or
subsidiary corporation.

          2.   The shares may, in the absolute discretion of the Plan
Administrator, be issued for consideration with a value less than one hundred
percent (100%) of the Fair Market Value of such shares at the time of issuance,
but in no event less than eighty-five percent (85%) of such Fair Market Value.

     B.   Vesting Provisions.

          1.   Shares of Common Stock issued under the Stock Issuance Program
may, in the absolute discretion of the Plan Administrator, be fully and
immediately vested upon issuance (as a bonus for past services) or may vest in
one or more installments over the Participant's period of Service or the
Corporation's attainment of performance milestones. The elements of the vesting
schedule applicable to any unvested shares of Common Stock issued under the
Stock Issuance Program, namely:

               (i)   the Service period to be completed by the Participant or
the performance objectives to be achieved by the Corporation,

               (ii)  the number of installments in which the shares are to vest,

               (iii) the interval or intervals (if any) which are to lapse
between installments, and

                                      B-15



               (iv)  the effect which death, Permanent Disability or other event
designated by the Plan Administrator is to have upon the vesting schedule, shall
be determined by the Plan Administrator and incorporated into the Issuance
Agreement executed by the Corporation and the Participant at the time such
unvested shares are issued.

          2.   The Participant shall have full shareholder rights with respect
to any shares of Common Stock issued to him or her under the Plan, whether or
not his or her interest in those shares is vested. Accordingly, the Participant
shall have the right to vote such shares and to receive any regular cash
dividends paid on such shares. Any new, additional or different shares of stock
or other property (including money paid other than as a regular cash dividend)
which the Participant may have the right to receive with respect to his or her
unvested shares by reason of any stock dividend, stock split, recapitalization,
combination of shares, exchange of shares or other change affecting the
outstanding Common Stock as a class without the Corporation's receipt of
consideration or by reason of any Corporate Transaction, shall be issued subject
to (i) the same vesting requirements applicable to his or her unvested shares
and (ii) such escrow arrangements as the Plan Administrator shall deem
appropriate.

          3.   Should the Participant cease to remain in Service while holding
one or more unvested shares of Common Stock under the Stock Issuance Program,
then the Corporation shall have the right to require the Participant to
surrender those shares immediately to the Corporation for cancellation, and the
Participant shall cease to have any further shareholder rights with respect to
the surrendered shares. To the extent the surrendered shares were previously
issued to the Participant for consideration paid in cash or cash equivalent
(including the Participant's purchase-money promissory note), the Corporation
shall repay to the Participant the cash consideration paid for the surrendered
shares and shall cancel the unpaid principal balance of any outstanding
purchase-money note of the Participant attributable to such surrendered shares.

          4.   The Plan Administrator may in its discretion elect to waive the
surrender and cancellation of one or more unvested shares of Common Stock (or
other assets attributable thereto) which would otherwise occur upon the
non-completion of the vesting schedule applicable to such shares. Such waiver
shall result in the immediate vesting of the Participant's interest in the
shares of Common Stock as to which the waiver applies. Such waiver may be
effected at any time, whether before or after the Participant's cessation of
Service or the attainment or non-attainment of the applicable performance
objectives.

II.  CORPORATE TRANSACTION/CHANGE IN CONTROL

     A.   All of the Corporation's outstanding repurchase rights under this
Article Three shall automatically terminate upon the occurrence of a Corporate
Transaction, except to the extent the Corporation's outstanding repurchase
rights are expressly assigned to the successor corporation (or parent thereof)
in connection with such Corporate Transaction. However, any assigned repurchase
rights covering the unvested shares held by a Participant under this Article
Three shall immediately terminate should there occur an Involuntary Termination
of that Participant's Service (other than for Misconduct) within eighteen (18)
months after such Corporate Transaction.

                                      B-16



     B.   The Plan Administrator shall have the discretionary authority,
exercisable either at the time the shares are issued under this Article Three or
at any time while those shares remain outstanding, to provide for the automatic
termination of the Corporation's repurchase rights with respect to those shares
should there occur a Change in Control. The Plan Administrator shall also have
full power and authority to condition the termination of those repurchase rights
upon the Participant's cessation of Service by reason of an Involuntary
Termination (other than for Misconduct) within a specified period following such
Change in Control.

III. SHARE ESCROW/TRANSFER RESTRICTIONS

     A.   Unvested shares may, in the Plan Administrator's discretion, be held
in escrow by the Corporation until the Participant's interest in such shares
vests or may be issued directly to the Participant with restrictive legends on
the certificates evidencing such unvested shares. To the extent an escrow
arrangement is utilized, the unvested shares and any securities or other assets
distributed with respect to such shares (other than regular cash dividends)
shall be delivered in escrow to the Corporation to be held until the
Participant's interest in such (or the distributed securities or assets) vests.

     B.   The Participant shall have no right to transfer any unvested shares of
Common Stock issued to him or her under the Stock Issuance Program. For purposes
of this restriction, the term "transfer" shall include (without limitation) any
sale, pledge, assignment, encumbrance, gift or other disposition of such shares,
whether voluntary or involuntary. Upon any such attempted transfer, the unvested
shares shall immediately be canceled in accordance with substantially the same
procedure in effect under Section I.B.3 of this Article Three, and neither the
Participant nor the proposed transferee shall have any rights with respect to
such canceled shares. However, the Participant shall have the right to make a
gift of unvested shares acquired under the Stock Issuance Program to his or her
spouse or issue, including adopted children, or to a trust established for such
spouse or issue, provided the transferee of such shares delivers to the
Corporation a written agreement to be bound by all the provisions of the Stock
Issuance Program and the Issuance Agreement applicable to the gifted shares.

                                  ARTICLE FOUR

                         AUTOMATIC OPTION GRANT PROGRAM

I.   ELIGIBILITY

          The individuals eligible to receive automatic option grants pursuant
to the provisions of this Article Four program shall be limited to (i) those
individuals who are serving as non-employee Board members on the Automatic
Option Grant Program Effective Date, (ii) those individuals who are first
elected or appointed as non-employee Board members on or after such Effective
Date, whether through appointment by the Board or election by the Corporation's
shareholders, and (iii) those individuals who are re-elected to serve as
non-employee Board members at one or more Annual Shareholders Meetings held
after the Section 12(g) Registration Date. In no event, however, shall a
non-employee Board member be eligible to receive an automatic option grant
pursuant to clause (i) or (ii) above if such individual has at any time been

                                      B-17



in the prior employ of the Corporation (or any parent or subsidiary
corporation), but such individual shall be eligible to receive one or more
automatic option grants pursuant to clause (iii). Each non-employee Board member
eligible to receive one or more automatic option grants pursuant to the
foregoing criteria shall be designated an "Eligible Director" for purposes of
the Plan.

II.  TERMS AND CONDITIONS OF AUTOMATIC OPTION

     A.   Grant Dates. Option grants shall be made under this Article Four on
the dates specified below:

          1.   Initial Grant. Each Eligible Director who is first elected or
appointed as a non-employee Board member after the Automatic Option Grant
Program Effective Date shall automatically be granted, on the date of such
initial election or appointment (as the case may be), a Non-Statutory Option to
purchase 30,000 shares of Common Stock upon terms and conditions of this Article
Four.

          2.   Annual Grant. On the date of each Annual Shareholders Meeting,
beginning with the first Annual Meeting held after the Section 12(g)
Registration Date, each individual who will continue to serve as an Eligible
Director shall automatically be granted, whether or not such individual is
standing for re-election as a Board member at that Annual Meeting, a
Non-Statutory Option to purchase an additional 10,000 shares of Common Stock
upon the terms and conditions of this Article Four, provided he or she has
served as a non-employee Board member for at least six (6) months prior to the
date of such Annual Meeting.

          3.   No Limitation. There shall be no limit on the number of shares
for which any one Eligible Director may be granted stock options under this
Article Four over his or her period of Board service.

     B.   Exercise Price. The exercise price per share of Common Stock subject
to each automatic option grant made under this Article Four shall be equal to
one hundred percent (100%) of the Fair Market Value per share of Common Stock,
on the automatic grant date.

     C.   Payment. The exercise price shall be payable in one of the alternative
forms specified below. To the extent the option is exercised for any unvested
shares, the Optionee must execute and deliver to the Corporation a stock
purchase agreement for those unvested shares which provides the Corporation with
the right to repurchase, at the exercise price paid per share, any unvested
shares held by the Optionee at the time of cessation of Board service and which
precludes the sale, transfer or other disposition of the purchased shares at any
time while those shares remain subject to the Corporation's repurchase right.

               (i)  full payment in cash or check drawn to the Corporation's
order;

               (ii) full payment in shares of Common Stock held for the
requisite period necessary to avoid a charge to the Corporation's earnings for
financial reporting purposes and valued at Fair Market Value on the Exercise
Date;

                                      B-18



               (iii) full payment in a combination of shares of Common Stock
held for the requisite period necessary to avoid a charge to the Corporation's
earnings for financial reporting purposes and valued at Fair Market Value on the
Exercise Date and cash or check drawn to the Corporation's order; or

               (iv)  to the extent the option is exercised for vested shares,
full payment through a sale and remittance procedure pursuant to which the
Optionee shall provide irrevocable written instructions to (a) a Corporation
designated brokerage firm to effect the immediate sale of the purchased shares
and remit to the Corporation, out of the sale proceeds available on the
settlement date, sufficient funds to cover the aggregate exercise price payable
for the purchased shares and (b) the Corporation to deliver the certificates for
the purchased shares directly to such brokerage firm in order to complete the
sale transaction.

          Except to the extent the sale and remittance procedure specified above
is used for the exercise of the option for vested shares, payment of the
exercise price for the purchased shares must accompany the exercise notice.

     D.   Option Term. Each automatic grant under this Article Four shall have a
maximum term of ten (10) years measured from the automatic grant date.

     E.   Exercisability/Vesting. Each automatic grant shall be immediately
exercisable for any or all of the option shares. However, any shares purchased
under the option shall be subject to repurchase by the Corporation, at the
exercise price paid per share, upon the Optionee's cessation of Board service
prior to vesting in those shares in accordance with the applicable schedule
below:

               Initial Grant. Each initial 30,000-share automatic grant shall
          vest, and the Corporation's repurchase right shall lapse, in a series
          of four successive and equal annual installments over the Optionee's
          period of continued service as a Board member, with the first such
          installment to vest upon Optionee's completion of one (1) year of
          Board service measured from the automatic grant date.

               Annual Grant. Each additional 10,000-share automatic grant shall
          vest, and the Corporation's repurchase right shall lapse, upon the
          Optionee's completion of one (1) year of Board service measured from
          the automatic grant date.

          Vesting of the option shares shall be subject to acceleration, as
provided in Section II.G.3 and Section III of this Article Four. In no event
shall any additional option shares vest after the Optionee's cessation of Board
service, except as otherwise provided in Section II.G.3 of this Article Four.

     F.   Non-Transferability.

          1.   During the lifetime of the Optionee, each automatic option grant,
together with the limited stock appreciation right pertaining to that option,
shall be exercisable only by the Optionee and shall not be assignable or
transferable by the Optionee, except for a transfer of the option by will or by
the laws of descent and distribution following Optionee's death or, with

                                      B-19



respect to options other than Incentive Options, if permitted in any specific
case by the Plan Administrator, pursuant to a domestic relations order (as
defined under the Code or Treasury Regulations).

          2.   Notwithstanding the foregoing, the Plan Administrator may provide
that an Optionee may transfer Non-Statutory Options to family members or other
persons or entities according to such terms as the Plan Administrator may
determine; provided that the Optionee receives no consideration for the transfer
of an option and the transferred option shall continue to be subject to the same
terms and conditions as were applicable to the option immediately before the
transfer.

     G.   Effect of Termination of Board Service.

          1.   Should the Optionee cease to serve as a Board member for any
reason (other than death or Permanent Disability) while holding one or more
automatic option grants under this Article Four, then such individual shall have
a six (6)-month period following the date of such cessation of Board service in
which to exercise each such option for any or all of the shares of Common Stock
in which the Optionee is vested at the time of such cessation of Board service.
However, each such option shall immediately terminate and cease to be
outstanding at the time of such cessation of Board service, with respect to any
shares in which the Optionee is not otherwise at that time vested under that
option.

          2.   Should the Optionee die within six (6) months after cessation of
Board service, then any automatic option grant held by the Optionee at the time
of death may subsequently be exercised. for any or all of the shares of Common
Stock in which the Optionee is vested at the time of his or her cessation of
Board service (less any option shares subsequently purchased by the Optionee
prior to death), by the personal representative of the Optionee's estate or by
the person or persons to whom the option is transferred pursuant to the
Optionee's will or in accordance with the laws of descent and distribution. The
right to exercise such option shall lapse upon the expiration of a twelve
(12)-month period measured from the date of the Optionee's death.

          3.   Should the Optionee die or become Permanently Disabled while
serving as a Board member, then the shares of Common Stock at the time subject
to each automatic option grant held by such Optionee under this Article Four
which are vested may be purchased by the Optionee (or the representative of the
Optionee's estate or the person or persons to whom the option is transferred
upon the Optionee's death) pursuant to the option for a twelve (12)-month period
following the date of the Optionee's cessation of Board service.

          4.   In no event shall any automatic grant under this Article Four
remain exercisable after the expiration date of the ten (10)-year option term.
Upon the expiration of the applicable post-service exercise period under
subparagraphs 1 through 3 above or (if earlier) upon the expiration of the ten
(10)-year option term, the automatic grant shall terminate and cease to be
outstanding for any option shares in which the Optionee was vested at the time
of his or her cessation of Board service but for which such option was not
subsequently exercised.

                                      B-20



     H.   Shareholder Rights. The holder of an automatic option grant under this
Article Four shall have none of the rights of a shareholder with respect to any
shares subject to such option until such individual shall have exercised the
option and paid the exercise price for the purchased shares.

     I.   Remaining Terms. The remaining terms and conditions of each automatic
option grant shall be as set forth in the form of Automatic Stock Option
Agreement attached as Exhibit A to the Plan.

III. CORPORATE TRANSACTION/CHANGE IN CONTROL/HOSTILE TAKE-OVER

     A.   In the event of any Corporate Transaction, the shares of Common Stock
at the time subject to each outstanding option under this Article Four but not
otherwise vested shall automatically vest in full so that each such option
shall, immediately prior to the specified effective date for the Corporate
Transaction, become fully exercisable for all of the shares of Common Stock at
the time subject to that option and may be exercised for all or any portion of
those shares as fully-vested shares. Immediately following the consummation of
the Corporate Transaction, all automatic option grants under this Article Four
shall terminate and cease to be outstanding, except to the extent one or more of
those grants are assumed by the acquiring entity or its parent corporation.

     B.   In connection with any Change in Control of the Corporation, the
shares of Common Stock at the time subject to each outstanding option under this
Article Four but not otherwise vested shall automatically vest in full so that
each such option shall, immediately prior to the specified effective date for
the Change in Control, become fully exercisable for all of the shares of Common
Stock at the time subject to that option and may be exercised for all or any
portion of those shares as fully-vested shares. Each such option shall remain so
exercisable for all the option shares following the Change in Control, until the
expiration or sooner termination of the option term.

     C.   Should a Hostile Take-Over occur at any time following the Section
12(g) Registration Date, then the Optionee shall have a thirty (30)-day period
in which to surrender to the Corporation each option held by him or her under
this Article Four for a period of at least six (6) months. The optionee shall in
return be entitled to a cash distribution from the Corporation in an amount
equal to the excess of (i) the Take-Over Price of the shares of Common Stock at
the time subject to the surrendered option (whether or not those shares are
otherwise at the time fully vested) over (ii) the aggregate exercise price
payable for such shares. The cash distribution shall be paid within five (5)
days following the surrender of the option to the Corporation. Neither the
approval of the Plan Administrator nor the consent of the Board shall be
required in connection with such option surrender and cash distribution. The
shares of Common Stock subject to each option surrendered in connection with the
Hostile Take-Over shall not be available for subsequent issuance under the Plan.

     D.   The automatic option grants outstanding under this Article Four shall
in no way affect the right of the Corporation to adjust, reclassify, reorganize
or otherwise change its capital or business structure or to merge, consolidate,
dissolve, liquidate or sell or transfer all or any part of its business or
assets.

                                      B-21



                                  ARTICLE FIVE

                        DIRECTOR FEE OPTION GRANT PROGRAM

I.   OPTION GRANTS

          Effective with respect to elections of Board members occurring at or
after the Company's regular 2003 annual meeting of shareholders, each
non-employee Board member may elect to receive all or any portion of the
retainer fees otherwise payable in cash for his or her service on the Board (on
any committee thereof) in the form of a special option grant under this Director
Fee Option Grant Program. Such election must be filed with the Corporation's
Chief Financial Officer prior to the shareholder vote that will determine
whether that Board member (or Board candidate) will be elected to serve or
continue to serve as a Board member and will apply to all retainer fees payable
during the entire term for which that Board member (or Board candidate) is then
nominated to serve. Each non-employee Board member (or Board candidate) who
files such a timely election and is then elected to serve as a Board member will
automatically be granted an option under this Director Fee Option Grant Program
on the date of the applicable shareholder vote.

          With respect to the period between January 1, 2003 and the Company's
regular 2003 annual meeting of shareholders, a pro-rata portion of the regular
annual retainer (the "Fractional Retainer") will be payable to non-employee
Board members. Each non-employee Board Member may elect to receive all or a
portion of the Fractional Retainer that would otherwise be payable in cash in
the form of a special option grant under this Director Fee Option Grant Program.
Such election must be filed with the Corporation's Chief Financial Officer prior
to the Company's regular 2002 annual meeting of shareholders and will apply only
to the Fractional Retainer. Each non-employee Board member (or Board candidate)
who files a timely election with respect to the Fractional Retainer and is then
elected to serve as a Board member at the Company's regular 2002 annual meeting
will automatically be granted an option under this Director Fee Option Grant
Program on the date of the Company's regular 2002 annual meeting of
shareholders.

II.  OPTION TERMS

          Each option shall be a Non-Statutory Option governed by the terms and
conditions specified below.

     A.   Exercise Price.

          1.   The exercise price per share will be thirty-three and one-third
percent (33-1/3%) of the Fair Market Value per share of Common Stock on the
option grant date.

          2.   The exercise price will become immediately due upon exercise of
the option and will be payable in one or more of the alternative forms
authorized under the Discretionary Option Grant Program. Except to the extent
the sale and remittance procedures specified thereunder is utilized, payment of
the exercise price for the purchased shares must be made on the Exercise Date.

                                      B-22



      B.   Number of Option Shares: The number of shares of Common Stock subject
to the option shall be determined pursuant to the following formula (rounded
down to the nearest whole number):

           X = A / (B x 66-2/3%), where

           X is the number of option shares,

           A is the portion of the annual retainer fee subject to the non-
           employee Board member's election, and

           B is the Fair Market Value per share of Common Stock on the option
           grant date.

      C.   Exercise and Term of Options. Each option granted under this Article
Five will be fully vested and immediately exercisable. Each such option will
have a maximum term of ten (10) years measured from the option grant date.

      D.   Effect of Termination of Service. Should the Optionee cease Board
service for any reason while holding one or more options under this Article
Five, then each such option will remain exercisable until the earlier of (i) the
expiration of the ten (10)-year option term or (ii) the expiration of the three
(3)-year period measured from the date of such cessation of Board service.

      E.   Death or Permanent Disability. Should the Optionee die while holding
one or more options under this Article Five, then each such option may be
exercised by the personal representative of the Optionee's estate or by the
person or persons to whom the option is transferred pursuant to the Optionee's
will or in accordance with the laws of descent and distribution.

III.  CORPORATE TRANSACTION/CHANGE IN CONTROL

      A.   In the event of any Corporate Transaction while the Optionee remains
a Board member, each outstanding option held by such Optionee under this
Director Fee Option Grant Program will be assumed by the successor corporation
(or parent thereof) in the Corporate Transaction and will remain exercisable
until the earlier of (i) the expiration of the ten (10)-year option term or (ii)
the expiration of the three (3)-year period measured from the date of the
Optionee's cessation of Board service.

      B.   The grant of options under the Director Fee Option Grant Program will
in no way affect the right of the Corporation to adjust, reclassify, reorganize
or otherwise change its capital or business structure or to merge, consolidate,
dissolve, liquidate or sell or transfer all or any part of its business or
assets.

IV.   REMAINING TERMS

           The remaining terms of each option granted under this Director Fee
Option Grant Program will be the same as the terms in effect for option grants
made under the Discretionary Option Grant Program.

                                      B-23



                                   ARTICLE SIX

                                  MISCELLANEOUS

I.    LOANS OR INSTALLMENT PAYMENTS

      A.   The Plan Administrator may, in its discretion, assist any Optionee or
Participant (including an Optionee or Participant who is an officer of the
Corporation) in the exercise of one or more options granted to such Optionee
under the Discretionary Option Grant and Automatic Option Grant Programs or the
purchase of one or more shares issued to such Participant under the Stock
Issuance Program, including the satisfaction of any Federal, state and local
income and employment tax obligations arising therefrom, by:

               (i)   authorizing the extension of a loan from the Corporation to
such Optionee or Participant, or

               (ii)  permitting the Optionee or Participant to pay the exercise
price or purchase price for the purchased Common Stock in installments over a
period of years.

      B.   The terms of any loan or installment method of payment (including the
interest rate and terms of repayment) shall be upon such terms as the Plan
Administrator specifies in the applicable option or issuance agreement or
otherwise deems appropriate at the time such exercise price or purchase price
becomes due and payable. Loans or installment payments may be authorized with or
without security or collateral. In all events, the maximum credit available to
the Optionee or Participant may not exceed the option or purchase price of the
acquired shares (less the par value of such shares) plus any Federal, state and
local income and employment tax liability incurred by the Optionee or
Participant in connection with the acquisition of such shares.

      C.   The Plan Administrator may, in its absolute discretion, determine
that one or more loans extended under this Section I shall be subject to
forgiveness by the Corporation in whole or in part upon such terms and
conditions as the Plan Administrator may in its discretion deem appropriate.

II.   AMENDMENT OF THE PLAN AND AWARDS

      A.   The Board has complete and exclusive power and authority to amend or
modify the Plan (or any component thereof) in any or all respects whatsoever.
However, (i) no such amendment or modification shall adversely affect rights and
obligations with respect to options at the time outstanding under the Plan, nor
adversely affect the rights of any Participant with respect to Common Stock
issued under the Stock Issuance Program prior to such action, unless the
Optionee or Participant consents to such amendment. In addition, the Board may
not, without the approval of the Corporation's shareholders, amend the Plan to
(i) increase the maximum number of shares issuable under the Plan or the maximum
amount of shares for which any one individual participating in the Plan may be
granted stock options, separately exercisable stock appreciation rights and
direct stock issuances for any given year under the Plan, except for permissible
adjustments under Article One, (ii) materially modify the eligibility
requirements for Plan participation, or (iii) otherwise materially increase the
benefits accruing to Plan participants.

                                      B-24



      B.   (i) Options to purchase shares of Common Stock may be granted under
the Discretionary Option Grant Program and (ii) shares of Common Stock may be
issued under the Stock Issuance Program, which are in both instances in excess
of the number of shares then available for issuance under the Plan, provided any
excess shares actually issued under the Discretionary Option Grant or the Stock
Issuance Programs are held in escrow until shareholder approval is obtained for
a sufficient increase in the number of shares available for issuance under the
Plan. If such shareholder approval is not obtained within twelve (12) months
after the date the first such excess option grants or excess share issuances are
made, then (i) any unexercised excess options shall terminate and cease to be
exercisable and (ii) the Corporation shall promptly refund the purchase price
paid for any excess shares actually issued under the Plan and held in escrow,
together with interest (at the applicable Short Term Federal Rate) for the
period the shares were held in escrow.

III.  TAX WITHHOLDING

      A.   The Corporation's obligation to deliver shares of Common Stock upon
the exercise of any stock options granted under Article Two or upon the issuance
of any shares under Article Three shall be subject to the satisfaction of all
applicable Federal, state and local income and employment tax withholding
requirements.

      B.   The Plan Administrator may, in its discretion and in accordance with
the provisions of this Section III of Article Six and such supplemental rules as
the Plan Administrator may from time to time adopt (including the applicable
safe-harbor provisions of Rule 16b-3 of the Securities and Exchange Commission),
provide any or all holders of Non-Statutory Options or unvested shares under the
Plan with the right to use shares of Common Stock in satisfaction of all or part
of the Federal, state and local income and employment tax liabilities incurred
by such holders in connection with the exercise of their options or the vesting
of their shares (the "Taxes"). Such right may be provided to any such holder in
either or both of the following formats:

               ----  The holder of the Non-Statutory Option or unvested shares
           may be provided with the election to have the Corporation withhold,
           from the shares of Common Stock otherwise issuable upon the exercise
           of such Non-Statutory Option or the vesting of such shares, a portion
           of those shares with an aggregate Fair Market Value equal to the
           percentage of the applicable Taxes (not to exceed one hundred percent
           (100%)) designated by the holder.

               ----  The Plan Administrator may, in its discretion, provide the
           holder of the Non-Statutory Option or the unvested shares with the
           election to deliver to the Corporation, at the time the Non-Statutory
           Option is exercised or the shares vest, one or more shares of Common
           Stock previously acquired by such individual (other than in
           connection with the option exercise or share vesting triggering the
           Taxes) with an aggregate Fair Market Value equal to the percentage of
           the Taxes incurred in connection with such option exercise or share
           vesting (not to exceed one hundred percent (100%)) designated by the
           holder.

                                      B-25



IV.   EFFECTIVE DATE AND TERM OF PLAN

      A.   The Discretionary Option Grant and Stock Issuance Programs of this
Plan became effective immediately upon adoption of the Plan by the Board on
March 23, 1995 (the "Plan Effective Date"). The Plan was approved by the
Corporation's shareholders on April 12, 1995. On December 9, 1995, the Board
approved an increase of 600,000 shares (which number reflects the 1-for-3
reverse stock split that was effected immediately prior to the consummation of
the initial public offering of the Common Stock) in the aggregate number of
shares issuable under the Plan; such increase was approved by the Corporation's
shareholders on December 19, 1995. The Automatic Option Grant Program of this
Plan became effective on the Automatic Option Grant Program Effective Date. The
Plan was amended by the Board on March 16, 1996 to implement the Director Fee
Option Grant Program, which amendment was approved by the Corporation's
shareholders at the 1996 Annual Stockholders Meeting. On March 19, 1997, the
Board approved an increase of 500,000 shares in the aggregate number of shares
issuable under the Plan, and on April 23, 1997, the Board approved a change in
the aggregate number of shares of Common Stock for which any one individual
participating in the Plan may be granted stock options, separately exercisable
stock appreciation rights and direct stock issuances, from a limitation of
250,000 shares over the term of the Plan, to an annual limitation not in excess
of 50% of the total number of shares for which stock options, separately
exercisable stock appreciation rights and direct stock issuances may be granted
over the term of the Plan. Both of such amendments became effective on April 23,
1997, and were approved by the Corporation's shareholders at the 1997 Annual
Stockholders Meeting. On April 16, 1999, the Board approved an increase of
495,000 shares in the aggregate number of shares issuable under the Plan and an
increase in the number of shares issuable to Eligible Directors under the annual
grant provisions of the Automatic Option Grant Program from 3,333 to 10,000
shares. Both of these changes became effective on June 15, 1999, upon their
approval by the Corporation's shareholders at the 1999 Annual Stockholders
Meeting. On April 17, 2000, the Board approved an increase of 690,000 shares in
the aggregate number of shares issuable under the Plan. This change became
effective on June 26, 2000, upon its approval by the Corporation's shareholders
at the 2000 Annual Stockholders Meeting. On March 21, 2001, the Board approved
an increase of 700,000 shares in the aggregate number of shares issuable under
the Plan. This change became effective on June 20, 2001, upon its approval by
the Corporation's shareholders at the 2001 Annual Stockholders Meeting. On April
10, 2002, the Board approved an increase of 1,200,000 shares in the aggregate
number of shares issuable under the Plan. This change became effective on June
25, 2002, upon its approval by the Corporation's shareholders at the 2002 Annual
Stockholders Meeting. On February 12, 2003, the Board approved an increase of
825,000 shares in the aggregate number of shares issuable under the Plan. This
change became effective on May 13, 2003, upon its approval by the Corporation's
shareholders at the 2003 Annual Stockholders Meeting.

      B.   Each stock option grant outstanding under the Predecessor Plans
immediately prior to the Plan Effective Date shall be incorporated into this
Plan and treated as an outstanding option under this Plan, but each such option
shall continue to be governed solely by the terms and conditions of the
instrument evidencing such grant, and nothing in this Plan shall be deemed to
affect or otherwise modify the rights or obligations of the holders of such
options with respect to their acquisition of shares of Common Stock thereunder.
However, the Plan Administrator shall have complete discretion to extend, under
such circumstances as it may deem appropriate,

                                      B-26



one or more provisions of this Plan to any or all of the stock options which are
incorporated into this Plan from the Predecessor Plans but which do not
otherwise contain such provisions.

      C.   No further option grants or stock issuances shall be made under the
Predecessor Plans from and after the Plan Effective Date.

      D.   The Plan shall terminate upon the earlier of (i) February 28, 2005 or
(ii) the date on which all shares available for issuance under the Plan shall
have been issued pursuant to the exercise of the options or stock appreciation
rights granted under the Plan or the issuance of shares (whether vested or
unvested) under the Stock Issuance Program. If the date of termination is
determined under clause (i) above, then all option grants and unvested share
issuances outstanding on such date shall thereafter continue to have force and
effect in accordance with the provisions of the instruments evidencing such
option grants or share issuances.

V.    NO EMPLOYMENT/SERVICE RIGHTS

           Neither the action of the Corporation in establishing the Plan, nor
any action taken by the Plan Administrator hereunder, nor any provision of the
Plan shall be construed so as to grant any individual the right to remain in the
employ or service of the Corporation (or any parent or subsidiary corporation)
for any period of specific duration, and the Corporation (or any parent or
subsidiary corporation retaining the services of such individual) may terminate
such individual's employment or service at any time and for any reason, with or
without cause.

VI.   USE OF PROCEEDS

           Any cash proceeds received by the Corporation from the sale of shares
pursuant to option grants or share issuances under the Plan shall be used for
general corporate purposes.

VII.  REGULATORY APPROVALS

           The implementation of the Plan, the granting of any option under the
Plan, the issuance of any shares under the Stock Issuance Program, and the
issuance of Common Stock upon the exercise or surrender of the option grants
made hereunder shall be subject to the Corporation's procurement of all
approvals and permits required by regulatory authorities having jurisdiction
over the Plan, the options granted under it, and the Common Stock issued
pursuant to it.

VIII. CHANGE OF CONTROL/CORPORATE TRANSACTION

           Notwithstanding any other provision of the Plan to the contrary, in
the event of a Corporate Transaction or a Change in Control, the Plan
Administrator shall not have the right to take any actions described in the
Plan, nor shall any provisions of the Plan be operative, if such actions or
provisions would make the Corporate Transaction or Change in Control ineligible
for pooling of interests accounting treatment or would make the Corporate
Transaction or Change in Control ineligible for desired tax treatment if, in the
absence of such actions or provisions, the Corporate Transaction or Change in
Control would qualify for such treatment and the Corporation intends to use such
treatment with respect to the Corporate Transaction or Change in Control.

                                      B-27



IX.   MISCELLANEOUS PROVISIONS

      A.   The right to acquire Common Stock or other assets under the Plan may
not be assigned, encumbered or otherwise transferred by any Optionee or
Participant.

      B.   The provisions of the Plan relating to the exercise of options and
the vesting of shares shall be governed by the laws of the Commonwealth of
Pennsylvania as such laws are applied to contracts entered into and performed in
such Commonwealth.

      C.   The provisions of the Plan shall inure to the benefit of, and be
binding upon, the Corporation and its successors or assigns, whether by
Corporate Transaction or otherwise, and the Participants and Optionees, the
legal representatives of their respective estates, their respective heirs or
legatees and their permitted assignees.

                                      B-28



                                                                      Appendix C

                            NEOSE TECHNOLOGIES, INC.
                          EMPLOYEE STOCK PURCHASE PLAN

I.     PURPOSE OF THE PLAN

              This Employee Stock Purchase Plan is intended to promote the
interests of Neose Technologies, Inc. by providing eligible employees with the
opportunity to acquire a proprietary interest in the Corporation through
participation in a payroll-deduction based employee stock purchase plan designed
to qualify under Section 423 of the Code.

              Capitalized terms herein shall have the meanings assigned to such
terms in the attached Appendix.

II.    ADMINISTRATION OF THE PLAN

              The Plan Administrator shall have full authority to interpret and
construe any provision of the Plan and to adopt such rules and regulations for
administering the Plan as it may deem necessary in order to comply with the
requirements of Code Section 423. Decisions of the Plan Administrator shall be
final and binding on all parties having an interest in the Plan.

III.   STOCK SUBJECT TO PLAN

       A. The stock purchasable under the Plan shall be shares of authorized but
unissued or reacquired Common Stock, including shares of Common Stock purchased
on the open market. The maximum number of shares of Common Stock which may be
issued over the term of the Plan shall not exceed 183,000 shares.

       B. Should any change be made to the Common Stock by reason of any stock
split, stock dividend, recapitalization, combination of shares, exchange of
shares or other change affecting the outstanding Common Stock as a class without
the Corporation's receipt of consideration, appropriate adjustments shall be
made to (i) the maximum number and class of securities issuable under the Plan,
(ii) the maximum number and class of securities purchasable per Participant on
any one Purchase Date and (iii) the number and class of securities and the price
per share in effect under each outstanding purchase right in order to prevent
the dilution or enlargement of benefits thereunder.

IV.    OFFERING PERIODS

       A. Shares of Common Stock shall be offered for purchase under the Plan
through a series of successive offering periods until such time as (i) the
maximum number of shares of Common Stock available for issuance under the Plan
shall have been purchased or (ii) the Plan shall have been sooner terminated.

       B. Each offering period shall be of such duration (not to exceed twenty-
four (24) months) as determined by the Plan Administrator prior to the start
date. The initial offering period shall commence at the Effective Time and
terminate on the last business day in January

                                       C-1



1998. The next offering period shall commence on the first business day in
February 1998, and subsequent offering periods shall commence as designated by
the Plan Administrator.

       C. Each offering period shall be comprised of a series of one or more
successive Purchase Periods. Purchase Periods shall begin on the first business
day in February and August each year and terminate on the last business day in
the following July and January, respectively, each year. However, the first
Purchase Period under the initial offering period shall commence at the
Effective Time and terminate on the last business day in July 1996.

V.     ELIGIBILITY

       A. Each individual who is an Eligible Employee at the Effective Time may
enter an offering period under the Plan on the start date of any Purchase Period
within that offering period, provided he or she remains an Eligible Employee on
such start date.

       B. Each individual who first becomes an Eligible Employee after the
Effective Time may enter an offering period under the Plan on the start date of
any Purchase Period following his or her completion of one (1) month of Service,
provided he or she remains an eligible Employee on such start date.

       C. The date an individual enters the offering period shall be designated
his or her Entry Date for purposes of that offering period.

       D. To participate in the Plan for a particular offering period, the
Eligible Employee must complete the enrollment forms prescribed by the Plan
Administrator (including a stock purchase agreement and a payroll deduction
authorization form) and file such forms with the Plan Administrator (or its
designate) on or before his or her scheduled Entry Date.

VI.    PAYROLL DEDUCTIONS

       A. The payroll deduction authorized by the Participant for purposes of
acquiring shares of Common Stock under the Plan may be any multiple of one
percent (1%) of the Base Salary paid to the Participant during each Purchase
Period within that offering period, up to a maximum of ten percent (10%). The
deduction rate so authorized shall continue in effect for the remainder of the
offering period, except to the extent such rate is changed in accordance with
the following guidelines:

              (i)   The Participant may, at any time during the offering period,
       reduce his or her rate of payroll deduction to become effective as soon
       as possible after filing the appropriate form with the Plan
       Administrator. The Participant may not, however, effect more than one (1)
       such reduction per Purchase Period.

              (ii)  The Participant may, prior to the commencement of any new
       Purchase Period within the offering period, increase the rate of his or
       her payroll deduction by filing the appropriate form with the Plan
       Administrator. The new rate (which may not exceed the ten percent (10%)
       maximum) shall become effective as of the start date of the Purchase
       Period following the filing of such form.

                                      C-2



       B. Payroll deductions shall begin on the first pay day following the
Participant's Entry Date into the offering period and shall (unless sooner
terminated by the Participant) continue through the pay day ending with or
immediately prior to the last day of that offering period. The amounts so
collected shall be credited to the Participant's book account under the Plan,
but no interest shall be paid on the balance from time to time outstanding in
such account. The amounts collected from the Participant shall not be held in
any segregated account or trust fund and may be commingled with the general
assets of the Corporation and used for general corporate purposes.

       C. Payroll deductions shall automatically cease upon the termination of
the Participant's purchase right in accordance with the provisions of the Plan.

       D. The Participant's acquisition of Common Stock under the Plan on any
Purchase Date shall neither limit nor require the Participant's acquisition of
Common Stock on any subsequent Purchase Date, whether within the same or a
different offering period.

VII.   PURCHASE RIGHTS

       A. Grant of Purchase Right. A Participant shall be granted a separate
purchase right for each offering period in which he or she participates. The
purchase right shall be granted on the Participant's Entry Date into the
offering period and shall provide the Participant with the right to purchase
shares of Common Stock, in a series of successive installments over the
remainder of such offering period, upon the terms set forth below. The
Participant shall execute a stock purchase agreement embodying such terms and
such other provisions (not inconsistent with the Plan) as the Plan Administrator
may deem advisable.

           Under no circumstances shall purchase rights be granted under
the Plan to any Eligible Employee if such individual would, immediately after
the grant, own (within the meaning of Code Section 424(d)) or hold outstanding
options or other rights to purchase, stock possessing five percent (5%) or more
of the total combined voting power or value of all classes of stock of the
Corporation or any Corporate Affiliate.

       B. Exercise of the Purchase Right. Each purchase right shall be
automatically exercised in installments on each successive Purchase Date within
the offering period, and shares of Common Stock shall accordingly be purchased
on behalf of each Participant (other than any Participant whose payroll
deductions have previously been refunded in accordance with the Termination of
Purchase Right provisions below) on each such Purchase Date. The purchase shall
be effected by applying the Participant's payroll deductions for the Purchase
Period ending on such Purchase Date (together with any carryover deductions from
the preceding Purchase Period) to the purchase of shares of Common Stock
(subject to the limitation on the maximum number of shares purchasable per
Participant on any one Purchase Date) at the purchase price in effect for the
Participant for that Purchase Date.

       C. Purchase Price. The purchase price per share at which Common Stock
will be purchased on the Participant's behalf on each Purchase Date within the
offering period shall be equal to eighty-five percent (85%) of the lower of (i)
the Fair Market Value per share of Common Stock on the Participant's Entry Date
into that offering period or (ii) the Fair Market

                                      C-3



Value per share of Common Stock on that Purchase Date. However, for each
Participant whose Entry Date is other than the start date of the offering
period, the clause (i) amount shall in no event be less than the Fair Market
Value per share of Common Stock on the start date of that offering period.

       D. Number of Purchasable Shares. The number of shares of Common Stock
purchasable by a Participant on each Purchase Date during the offering period
shall be the number of shares obtained by dividing the amount collected from the
Participant through payroll deductions during the Purchase Period ending with
that Purchase Date (together with any carryover deductions from the preceding
Purchase Period) by the purchase price in effect for the Participant for that
Purchase Date. However, the maximum number of shares of Common Stock purchasable
per Participant on any one Purchase Date shall not exceed 1,000 shares, subject
to periodic adjustments in the event of certain changes in the Corporation's
capitalization.

       E. Excess Payroll Deductions. Any payroll deductions not applied to the
purchase of Common Stock by reason of the limitation on the maximum number of
shares purchasable by the Participant on the Purchase Date shall be promptly
refunded.

       F. Termination of Purchase Right. The following provisions shall govern
the termination of outstanding purchase rights:

              (i)    A Participant may, at any nine prior to the next Purchase
       Date in the offering period, terminate his or her outstanding purchase
       right by filing the appropriate form with the Plan Administrator (or its
       designate), and no further payroll deductions shall be collected from the
       Participant with respect to the terminated purchase right. Any payroll
       deductions collected during the Purchase Period in which such termination
       occurs shall, at the Participant's election, be immediately refunded or
       held for the purchase of shares on the next Purchase Dare. If no such
       election is made at the time such purchase right is terminated, then the
       payroll deductions collected with respect to the terminated right shall
       be refunded as soon as possible.

              (ii)   The termination of such purchase right shall be
       irrevocable, and the Participant may not subsequently rejoin the offering
       period for which the terminated purchase right was granted. In order to
       resume participation in any subsequent offering period, such individual
       must re-enroll in the Plan (by making a timely filing of the prescribed
       enrollment forms) on or before his or her scheduled Entry Dale into that
       offering period.

              (iii)  Should the Participant cease to remain an Eligible Employee
       for any reason (including death, disability or change in status) while
       his or her purchase right remains outstanding, then that purchase right
       shall immediately terminate, and all of the Participant's payroll
       deductions for the Purchase Period in which the purchase right so
       terminates shall, at the Participant's election, be immediately refunded
       or held for the purchase of shares on the next Purchase Date. If no such
       election is made at the time such purchase right is terminated, then the
       payroll deductions collected with respect to the terminated right shall
       be refunded as soon as possible.

                                      C-4



              (iv)   Should the Participant cease to remain in active service by
       reason of an approved unpaid leave of absence, then the Participant shall
       have the election, exercisable up until the last business day of the
       Purchase Period in which such leave commences, to (a) withdraw all the
       payroll deductions collected during such Purchase Period or (b) have such
       funds held for the purchase of shares at the end of such Purchase Period.
       In no event, however, shall any further payroll deductions be collected
       from the Participant during such leave. Upon the Participant's return to
       active service, his or her payroll deductions under the Plan shall
       automatically resume at the rate in effect at the time the leave began.

       G. Corporate Transaction. Each outstanding purchase right shall
automatically be exercised, immediately prior to the effective date of any
Corporate Transaction, by applying the payroll deductions of each Participant
for the Purchase Period in which such Corporate Transaction occurs to the
purchase of shares of Common Stock at a purchase price per share equal to
eighty-five percent (85%) of the lower of (i) the Fair Market Value per share of
Common Stock on the Participant's Entry Date into the offering period in which
such Corporate Transaction occurs or (ii) the Fair Market Value per share of
Common Stock immediately prior to the effective date of such Corporate
Transaction. However, the applicable limitation on the number of shares of
Common Stock purchasable per Participant shall continue to apply to any such
purchase, and the clause (i) amount above shall not, for any Participant whose
Entry Date for the offering period is other than the start date of that offering
period, be less than the Fair Market Value per share of Common Stock on such
start date.

                  The Corporation shall use its best efforts to provide at least
ten (10)-days prior written notice of the occurrence of any Corporate
Transaction, and Participants shall, following the receipt of such notice, have
the right to terminate their outstanding purchase rights prior to the effective
date of the Corporate Transaction.

       H. Proration of Purchase Rights. Should the total number of shares of
Common Stock which are to be purchased pursuant to outstanding purchase rights
on any particular date exceed the number of shares then available for issuance
under the Plan, the Plan Administrator shall make a pro-rata allocation of the
available shares on a uniform and nondiscriminatory basis, and the payroll
deductions of each Participant, to the extent in excess of the aggregate
purchase price payable for the Common Stock pro-rated to such individual, shall
be refunded.

       I. Assignability. During the Participant's lifetime, the purchase right
shall be exercisable only by the Participant and shall not be assignable or
transferable by the Participant.

       J. Stockholder Rights. A Participant shall have no stockholder rights
with respect to the shares subject to his or her outstanding purchase right
until the shares are purchased on the Participant's behalf in accordance with
the provisions of the Plan and the Participant has become a holder of record of
the purchased shares.

VIII.  ACCRUAL LIMITATIONS

       A. No Participant shall be entitled to accrue rights to acquire Common
Stock pursuant to any purchase right outstanding under this Plan if and to the
extent such accrual, when aggregated

                                      C-5



with (i) rights to purchase Common Stock accrued under any other purchase right
granted under this Plan and (ii) similar rights accrued under other employee
stock purchase plans (within the meaning of Code Section 423) of the Corporation
or any Corporate Affiliate, would otherwise permit such Participant to purchase
more than Twenty-Five Thousand Dollars ($25,000) worth of stock of the
Corporation or any Corporate Affiliate (determined on the basis of the Fair
Market Value of such stock on the date or dates such rights are granted) for
each calendar year such rights are at any time outstanding.

     B. For purposes of applying such accrual limitations, the following
provisions shall be in effect:

               (i)  The right to acquire Common Stock under each outstanding
     purchase right shall accrue in a series of installments on each successive
     Purchase Dare during the offering period on which such right remains
     outstanding.

               (ii) No right to acquire Common Stock under any outstanding
     purchase right shall accrue to the extent the Participant has already
     accrued in the same calendar year the right to acquire Common Stock under
     one (1) or more other purchase rights at a rate equal to Twenty-Five
     Thousand Dollars ($25,000) worth of Common Stock (determined on the basis
     of the Fair Market Value of such stock on the date or dates of grant) for
     each calendar year such rights were at any time outstanding.

     C. If by reason of such accrual limitations, any purchase right of a
Participant does not accrue for a particular Purchase Period, then the payroll
deductions which the Participant made during that Purchase Period with respect
to such purchase right shall be promptly refunded.

     D. In the event there is any conflict between the provisions of this
Article and one or more provisions of the Plan or any instrument issued
thereunder, the provisions of this Article shall be controlling.

IX.  EFFECTIVE DATE AND TERM OF THE PLAN

     A. The Plan was adopted by the Board on December 6, 1995 and shall become
effective at the Effective Time, provided no purchase rights granted under the
Plan shall be exercised, and no shares of Common Stock shall be issued
hereunder, until (i) the Plan shall have been approved by the stockholders of
the Corporation and (ii) the Corporation shall have complied with all applicable
requirements of the 1933 Act (including the registration of the shares of Common
Stock issuable under the Plan on a Form S-8 registration statement filed with
the Securities and Exchange Commission), all applicable listing requirements of
any stock exchange (or the Nasdaq National Market, if applicable) on which the
Common Stock is listed for trading and all other applicable requirements
established by law or regulation. In the event such stockholder approval is not
obtained, or such compliance is not effected, within twelve (12) months after
the date on which the Plan is adopted by the Board, the Plan shall terminate and
have no further force or effect and all sums collected from Participants during
the initial offering period hereunder shall be refunded.

     B. Unless sooner terminated by the Board, the Plan shall terminate upon the
earliest of (i) the last business day in January 2006, (ii) the date on which
all shares available for issuance

                                       C-6



under the Plan shall have been sold pursuant to purchase rights exercised under
the Plan or (iii) the date on which all purchase rights are exercised in
connection with a Corporate Transaction. No further purchase rights shall be
granted or exercised, and no further payroll deductions shall be collected,
under the Plan following its termination.

X.   AMENDMENT OF THE PLAN

          The Board may alter, amend, suspend or discontinue the Plan at any
time to become effective immediately following the close of any Purchase Period.
However, the Board may not, without the approval of the Corporation's
stockholders, (i) materially increase the number of shares of Common Stock
issuable under the Plan or the maximum number of shares purchasable per
Participant on any one Purchase Date, except for permissible adjustments in the
event of certain changes in the Corporation's capitalization, (ii) alter the
purchase price formula so as to reduce the purchase price payable for the shares
of Common Stock purchasab1e under the Plan, or (iii) materially increase the
benefits accruing to Participants under the Plan or materially modify the
requirements for eligibility to participate in the Plan.

XI.  GENERAL PROVISIONS

     A. All costs and expenses incurred in the administration of the Plan shall
be paid by the Corporation.

     B. Nothing in the Plan shall confer upon the Participant any right to
continue in the employ of the Corporation or any Corporate Affiliate for any
period of specific duration or interfere with or otherwise restrict in any way
the rights of the Corporation (or any Corporate Affiliate employing such person)
or of the Participant, which rights are hereby expressly reserved by each, to
terminate such person's employment at any time for any reason, with or without
cause.

     C. The provisions of the Plan shall be governed by the laws of the State of
Pennsylvania without resort to that State's conflict-of-laws rules.

                                       C-7



                                   Schedule A

                          Corporations Participating in
                          Employee Stock Purchase Plan
                            As of the Effective Time


                            Neose Technologies, Inc.

                                       C-8



                                    APPENDIX

                  The following definitions shall be in effect under the Plan:

     A. Base Salary shall mean the regular base salary paid to a Participant by
one or more Participating Companies during such individual's period of
participation in the Plan, plus any pre-tax contributions made by the
Participant to any Code Section 401(k) salary deferral plan or any Code Section
125 cafeteria benefit program now or hereafter established by the Corporation or
any Corporate Affiliate. The following items of compensation shall not be
included in Base Salary: (i) all overtime payments, bonuses, commissions (other
than those functioning as base salary equivalents), profit-sharing distributions
and other incentive-type payments and (ii) any and all contributions (other than
Code Section 401(k) or Code Section 125 contributions) made on the Participant's
behalf by the Corporation or any Corporate Affiliate under any employee benefit
or welfare plan now or hereafter established.

     B. Board shall mean the Corporation's Board of Directors.

     C. Code shall mean the Internal Revenue Code of 1986, as amended.

     D. Common Stock shall mean the Corporation's common stock

     E. Corporate Affiliate shall mean any parent or subsidiary corporation of
the Corporation (as determined in accordance with Code Section 424), whether now
existing or subsequently established.

     F. Corporate Transaction shall mean either of the following
stockholder-approved transactions to which the Corporation is a party:

               (i)  a merger or consolidation in which securities possessing
     more than fifty percent (50%) of the total combined voting power of the
     Corporation's outstanding securities are transferred to a person or persons
     different from the persons holding those securities immediately prior to
     such transaction, or

               (ii) the sale, transfer or other disposition of all or
     substantially all of the assets of the Corporation in complete liquidation
     or dissolution of the Corporation.

     G. Corporation shall mean Neose Technologies, Inc., a Delaware corporation,
and any corporate successor to all or substantially all of the assets or voting
stock of Neose Technologies, Inc. which shall by appropriate action adopt the
Plan.

     H. Effective Time shall mean the time at which the Underwriting Agreement
is executed and finally priced. Any Corporate Affiliate which becomes a
Participating Corporation after such Effective Time shall designate a subsequent
Effective Time with respect to its employee-Participants.

     I. Eligible Employee shall mean any person who is employed by a
Participating Corporation on a basis under which he or she is regularly expected
to render more than twenty

                                       C-9



(20) hours of service per week for more than five (5) months per calendar year
for earnings considered wages under Code Section 3401(a).

     J. Entry Date shall mean the date an Eligible Employee first commences
participation in the offering period in effect under the Plan. The earliest
Entry Date under the Plan shall be the Effective Time.

     K. Fair Market Value per share of Common Stock on any relevant date shall
be determined in accordance with the following provisions:

               (i)   If the Common Stock is at the time traded on the Nasdaq
     National Market, then the Fair Market Value shall be the closing selling
     price per share of Common Stock on the date in question, as such price is
     reported by the National Association of Securities Dealers on the Nasdaq
     National Market or any successor system. If there is no closing selling
     price for the Common Stock on the date in question, then the Fair Market
     Value shall be the closing selling price on the last preceding date for
     which such quotation exists.

               (ii)  If the Common Stock is at the time listed on any Stock
     Exchange, then the Fair Market Value shall be the closing selling price per
     share of Common Stock on the date in question on the Stock Exchange
     determined by the Plan Administrator to be the primary market for the
     Common Stock, as such price is officially quoted in the composite tape of
     transactions on such exchange. If there is no closing selling price for the
     Common Stock on the date in question, then the Fair Market Value shall be
     the closing selling price on the last preceding date for which such
     quotation exists.

               (iii) For purposes of the initial offering period which begins at
     the Effective Time, the Fair Market Value shall be deemed to be equal to
     the price per share at which the Common Stock is sold in the initial public
     offering pursuant to the Underwriting Agreement.

     L. 1933 Act shall mean the Securities Act of 1933, as amended.

     M. Participant shall mean any Eligible Employee of a Participating
Corporation who is actively participating in the Plan.

     N. Participating Corporation shall mean the Corporation and such Corporate
Affiliate or Affiliates as may be authorized from time to time by the Board to
extend the benefits of the Plan to their Eligible Employees. The Participating
Corporations in the Plan as of the Effective Time are listed in attached
Schedule A.

     O. Plan shall mean the Corporation's Employee Stock Purchase Plan, as set
forth in this document.

     P. Plan Administrator shall mean the committee of two (2) or more Board
members appointed by the Board to administer the Plan.

                                      C-10



     Q. Purchase Date shall mean the last business day of each Purchase Period.
The initial Purchase Date shall be July 31, 1996.

     R. Purchase Period shall mean each successive period within the offering
period at the end of which there shall be purchased shares of Common Stock on
behalf of each Participant.

     S. Service shall mean an individual's performance of services for the
Corporation or any Corporate Affiliate as an employee, subject to the control
and direction of the employer entity as to both the work to be performed and the
manner and method of performance.

     T. Stock Exchange shall mean either the American Stock Exchange or the New
York Stock Exchange.

     U. Underwriting Agreement shall mean the agreement between the Corporation
and the underwriter or underwriters managing the initial public offering of the
Common Stock.

                                      C-11



                            Neose Technologies, Inc.
             PROXY FOR ANNUAL MEETING OF STOCKHOLDERS - May 13, 2003
       (This Proxy is solicited by the Board of Directors of the Company)


The undersigned stockholder of Neose Technologies, Inc. hereby appoints C. Boyd
Clarke, President and Chief Executive Officer, Robert I. Kriebel, Senior Vice
President and Chief Financial Officer, and A. Brian Davis, Vice President,
Finance, and each of them, with full power of substitution, proxies to vote the
shares of stock that the undersigned could vote if personally present at the
Annual Meeting of Stockholders of Neose Technologies, Inc. to be held at the
Company's headquarters at 102 Witmer Road, Horsham, PA 19044, on May 13, 2003,
at 9:00 A.M. (Eastern Daylight Time), or any adjournment thereof.

          (Continued and to be signed on reverse side)



                         Annual Meeting of Stockholders
                            NEOSE TECHNOLOGIES, INC.

                                  May 13, 2003

                         Please date, sign and mail your
                      proxy card back as soon as possible.

       Please Detach and Mail in the Envelope Provided as soon as possible

________________________________________________________________________

PLEASE DATE, SIGN AND RETURN PROMPTLY IN THE ENCLOSED ENVELOPE. PLEASE MARK YOUR
                   VOTE IN BLUE OR BLACK INK AS SHOWN HERE [X]


1.  ELECTION        FOR ALL NOMINEES         WITHHOLD       FOR ALL EXCEPT
    OF                                       AUTHORITY      (See instructions
    DIRECTORS                                FOR ALL        below)
                                             NOMINEES
                          [_]                    [_]              [_]

INSTRUCTION: To withhold authority to vote for
any individual nominee(s), mark "FOR ALL EXCEPT"
and fill in the circle next to each nominee you
wish to withhold, as shown here:        O

                         NOMINEES:  O  C. Boyd Clarke
                                    O  Brian H. Dovey
                                    O  L. Patrick Gage
                                    O  William F. Hamilton
                                    O  Douglas J. MacMaster, Jr.
                                    O  Mark H. Rachesky
                                    O  Stephen A. Roth
                                    O  Lowell E. Sears
                                    O  Elizabeth H.S. Wyatt


2. PROPOSAL TO RATIFY THE APPOINTMENT OF KPMG LLP AS OUR INDEPENDENT AUDITORS
FOR FISCAL 2003.

                               FOR     AGAINST     ABSTAIN
                               [_]       [_]         [_]


3. PROPOSAL TO APPROVE AND ADOPT AN AMENDMENT TO THE NEOSE TECHNOLOGIES, INC.
AMENDED AND RESTATED 1995 STOCK OPTION/STOCK ISSUANCE PLAN (THE "PLAN") TO
INCREASE THE NUMBER OF SHARES ISSUABLE UNDER THE PLAN BY 825,000 SHARES.

                               FOR     AGAINST     ABSTAIN
                               [_]       [_]         [_]



4. PROPOSAL TO APPROVE AND ADOPT AN AMENDMENT TO OUR EMPLOYEE STOCK PURCHASE
PLAN TO INCREASE THE NUMBER OF SHARES ISSUABLE UNDER THE PLAN BY 33,000 SHARES.

                               FOR     AGAINST     ABSTAIN
                               [_]       [_]         [_]


5. IN THEIR DISCRETION UPON SUCH OTHER MATTERS AS MAY PROPERLY COME BEFORE THE
MEETING.

UNLESS OTHERWISE SPECIFIED, THIS PROXY WILL BE VOTED FOR THE ELECTION OF
DIRECTORS NAMED IN PROPOSAL 1 AND FOR PROPOSALS 2, 3 AND 4.

THE UNDERSIGNED HEREBY ACKNOWLEDGES RECEIPT OF THE NOTICE OF ANNUAL MEETING OF
STOCKHOLDERS AND THE RELATED PROXY STATEMENT.

Signature of Shareholder__________________________________   Date:__________
Signature of Shareholder__________________________________   Date:__________

Note: Please sign exactly as your name or names appear on this Proxy. When
shares are held jointly, each holder should sign.

To change the address on your account, please check the box at right and
indicate your new address in the address space above. Please note that changes
to the registered name(s) on the account may not be submitted via this method.

When signing as Executor, administrator, attorney, trustee, or guardian, please
give full title as such. If the signer is a corporation, please sign full
corporate name by duly authorized officer, giving full title as such. If signer
is a partnership, please sign in partnership name by authorized person.