FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person * MITCHELL PAUL J   2. Issuer Name and Ticker or Trading Symbol Alkermes plc. [ALKS] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) CONNAUGHT HOUSE, 1 BURLINGTON ROAD 3. Date of Earliest Transaction (Month/Day/Year) 12/03/2018 (Street) DUBLIN 4 IRELAND  4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Ordinary Shares 12/03/2018   M(1)   1,000 A $ 8.98 1,000 I The Paul J. Mitchell Trust (2) Ordinary Shares 12/03/2018   S(3)   1,000 D $ 36.45 0 I The Paul J. Mitchell Trust (2) Ordinary Shares               8,000 D

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Non Qualified Stock Option (Right to Buy)

$ 8.98

12/03/2018

M(1)

1,000

(4)

10/06/2019

Ordinary Shares

1,000

$ 0

11,000

I

The Paul J. Mitchell Trust (2) (5)

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
MITCHELL PAUL J CONNAUGHT HOUSE 1 BURLINGTON ROAD DUBLIN 4 IRELAND	X

Signatures

/s/ Jennifer Baptiste, attorney-in-fact for Paul J. Mitchell		12/06/2018
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	This option exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 12/12/17.
(2)	The reporting person and his wife are co-trustees of The Paul J. Mitchell Trust and the reporting person is also a beneficiary of The Paul J. Mitchell Trust originally established on November 19, 2014 and amended and restated on September 8, 2017 ("The Paul J. Mitchell Trust").
(3)	This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 12/12/17.
(4)	These options are fully vested in accordance with their terms.
(5)	These options were transferred from the reporting person to The Paul J. Mitchell Trust on December 11, 2017.

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