1. Title of Derivative Security (Instr. 4) |
2. Date Exercisable and Expiration Date (Month/Day/Year) |
3. Title and Amount of Securities Underlying Derivative Security (Instr. 4) |
4. Conversion or Exercise Price of Derivative Security |
5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5) |
6. Nature of Indirect Beneficial Ownership (Instr. 5) |
Date Exercisable |
Expiration Date |
Title |
Amount or Number of Shares |
Series E Preferred Stock
|
Â
(5)
|
Â
(5)
|
Common Stock
|
367,315
|
$
(5)
|
I
|
See Footnote
(2)
(3)
|
Series E Preferred Stock
|
Â
(5)
|
Â
(5)
|
Common Stock
|
3,498
|
$
(5)
|
I
|
See Footnote
(4)
|
Series D-2 Preferred Stock
|
Â
(6)
|
Â
(6)
|
Common Stock
|
219,863
|
$
(6)
|
I
|
See Footnote
(2)
(3)
|
Series D-2 Preferred Stock
|
Â
(6)
|
Â
(6)
|
Common Stock
|
2,094
|
$
(6)
|
I
|
See Footnote
(4)
|
Series D Preferred Stock
|
Â
(7)
|
Â
(7)
|
Common Stock
|
181,689
|
$
(7)
|
I
|
See Footnote
(2)
(3)
|
Series D Preferred Stock
|
Â
(7)
|
Â
(7)
|
Common Stock
|
1,730
|
$
(7)
|
I
|
See Footnote
(4)
|
Series D-2 Preferred Stock Warrants (Right to Buy)
|
05/18/2011 |
05/18/2021 |
Common Stock
|
57,217
(1)
|
$
0.024
|
I
|
See Footnote
(2)
(3)
|
Series D-2 Preferred Stock Warrants (Right to Buy)
|
05/18/2011 |
05/18/2021 |
Common Stock
|
544
(1)
|
$
0.024
|
I
|
See Footnote
(4)
|
Common Stock Warrants (Right to Buy)
|
10/26/2012 |
10/26/2022 |
Common Stock
|
559,441
(1)
|
$
0.24
|
I
|
See Footnote
(2)
(3)
|
Common Stock Warrants (Right to Buy)
|
10/26/2012 |
10/26/2022 |
Common Stock
|
5,328
(1)
|
$
0.24
|
I
|
See Footnote
(4)
|
Common Stock Warrants (Right to Buy)
|
12/11/2012 |
09/29/2020 |
Common Stock
|
1,848
(1)
|
$
36.96
|
I
|
See Footnote
(2)
(3)
|
Common Stock Warrants (Right to Buy)
|
12/11/2012 |
09/29/2020 |
Common Stock
|
17
(1)
|
$
36.96
|
I
|
See Footnote
(4)
|
Common Stock Warrants (Right to Buy)
|
12/11/2012 |
06/05/2019 |
Common Stock
|
8,540
(1)
|
$
21.84
|
I
|
See Footnote
(2)
(3)
|
Common Stock Warrants (Right to Buy)
|
12/11/2012 |
06/05/2019 |
Common Stock
|
81
(1)
|
$
21.84
|
I
|
See Footnote
(4)
|
* |
If the form is filed by more than one reporting person, see Instruction 5(b)(v). |
** |
Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a). |
(1) |
Reflects a 1-for-24 reverse split of the Issuer's common stock effected on April 24, 2013. |
(2) |
These shares of Series E convertible preferred stock, shares of Series D convertible preferred stock, shares of Series D-2 convertible preferred stock, shares of Common Stock, warrants to purchase Series D-2 convertible preferred stock and warrants to purchase Common Stock are held of record by OrbiMed Private Investments III, LP ("OPI") and may be deemed to be indirectly beneficially owned by OrbiMed Capital GP III LLC ("Capital"), OrbiMed Advisors LLC ("Advisors") and Samuel D Isaly ("Isaly"). Capital is the sole general partner of OPI. Advisors, a registered adviser under the Investment Advisers Act of 1940, as amended, is the sole managing member of Capital. By virtue of such relationships, Capital and Advisors have voting and investment power with respect to the securities held by OPI noted above. |
(3) |
Isaly, a natural person, may also be deemed to have voting and investment power with respect to the securities held by OPI noted above in his capacity as the managing member of, and holder of a controlling interest, in Advisors. As a result, each of Capital, Advisors and Isaly may be deemed to have beneficial ownership of the securities held by OPI. The Reporting Person is an employee of Advisors and disclaims beneficial ownership over such securities, except to the extent of his pecuniary interest therein, if any. |
(4) |
These shares of Series E convertible preferred stock, shares of Series D convertible preferred stock, shares of Series D-2 convertible preferred stock, shares of Common Stock, warrants to purchase Series D-2 convertible preferred stock and warrants to purchase Common Stock are held of record by OrbiMed Associates III, LP ("Associates") and may be deemed to be indirectly beneficially owned by Advisors and Isaly. Advisors is the sole general partner of Associates. Isaly is the managing member of, and holder of a controlling interest in, Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by Associates noted above. As a result, each of Advisors and Isaly may be deemed to have beneficial ownership of the securities held by Associates. The Reporting Person disclaims beneficial ownership over such securities, except to the extent of his pecuniary interest therein if any. |
(5) |
The Series E Preferred Stock has no expiration date and is convertible at any time at the option of the holder and will automatically convert upon the closing of the Issuer's initial public offering, at a conversion ratio of 1 share of Common Stock for every 24 shares of Series E Preferred Stock, for no additional consideration. |
(6) |
The Series D-2 Preferred Stock has no expiration date and is convertible at any time at the option of the holder and will automatically convert upon the closing of the Issuer's initial public offering, at a conversion ratio of 1 share of Common Stock for every 24 shares of Series D-2 Preferred Stock, for no additional consideration. |
(7) |
The Series D Preferred Stock has no expiration date and is convertible at any time at the option of the holder and will automatically convert upon the closing of the Issuer's initial public offering, at a conversion ratio of 1 share of Common Stock for every 24 shares of Series D Preferred Stock, for no additional consideration. |