Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Schaeffer Orlov S Nicole
 2. Date of Event Requiring Statement (Month/Day/Year)
05/30/2007		 3. Issuer Name and Ticker or Trading Symbol
AMICUS THERAPEUTICS INC [FOLD]
(Last)
(First)
(Middle)
C/O AMICUS THERAPEUTICS, INC., 6 CEDAR BROOK DRIVE		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
VP, HR & Leadership Devt
 5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

CRANBURY, NJ 08512		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 12,795
D
 

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Employee Stock Option (right to buy)   (1) 03/10/2015 Common Stock 10,156 $ 0.638 D  
Employee Stock Option (right to buy)   (2) 08/01/2015 Common Stock 4,027 $ 0.638 D  
Employee Stock Option (right to buy)   (3) 10/20/2015 Common Stock 10,000 $ 5.33 D  
Employee Stock Option (right to buy)   (4) 02/28/2016 Common Stock 20,000 $ 5.33 D  
Employee Stock Option (right to buy)   (5) 04/25/2017 Common Stock 23,334 $ 13.43 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Schaeffer Orlov S Nicole
C/O AMICUS THERAPEUTICS, INC.
6 CEDAR BROOK DRIVE
CRANBURY, NJ 08512		       VP, HR & Leadership Devt  

Signatures

/s/ Douglas A. Branch, Attorney-in-fact 05/30/2007
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) These options vest and become exercisable in a series of installments. The first installment, which consisted of 25% of the total aggregate number of options granted, vested on March 21, 2006. The remaining options vest and become exercisable in a series of thirty-five successive equal monthly installments of 424 shares, beginning on April 1, 2006, with the final installment of 393 shares vesting on March 1, 2009.
(2) These options vest and become exercisable in a series of installments. The first installment, which consisted of 25% of the total aggregate number of options granted, vested on August 1, 2006. The remaining options vest and become exercisable in a series of thirty-five successive equal monthly installments of 139 shares, beginning on September 1, 2006, with the final installment of 135 shares vesting on August 1, 2009.
(3) These options vest and become exercisable in a series of installments. The first installment, which consisted of 25% of the total aggregate number of options granted, vested on October 20, 2006. The remaining options vest and become exercisable in a series of thirty-five successive equal monthly installments of 209 shares, beginning on November 1, 2006, with the final installment of 185 shares vesting on October 1, 2009.
(4) These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, vest on February 28, 2007. The remaining options vest and become exercisable in a series of thirty-five successive equal monthly installments of 417 shares, beginning on March 1, 2007, with a final installment of 405 shares vesting on February 1, 2010.
(5) These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, will vest on April 25, 2008. The remaining options vest and become exercisable in a series of thirty-five successive equal monthly installments of 487 shares, beginning on May 1, 2008, with a final installment of 455 shares vesting on April 1, 2011.

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