Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Palling David
 2. Date of Event Requiring Statement (Month/Day/Year)
05/30/2007		 3. Issuer Name and Ticker or Trading Symbol
AMICUS THERAPEUTICS INC [FOLD]
(Last)
(First)
(Middle)
C/O AMICUS THERAPEUTICS, INC., 6 CEDAR BROOK DRIVE		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Senior VP, Drug Development
 5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

CRANBURY, NJ 08512		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 48,866
D
 
Common Stock 6,666 (1)
I
By David Palling Irrevocable Trust

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Employee Stock Option (right to buy)   (2) 12/15/2014 Common Stock 24,924 $ 0.638 D  
Employee Stock Option (right to buy)   (3) 10/20/2015 Common Stock 30,000 $ 5.33 D  
Employee Stock Option (right to buy)   (4) 02/28/2016 Common Stock 2,667 $ 5.33 D  
Employee Stock Option (right to buy)   (5) 04/25/2017 Common Stock 16,667 $ 13.43 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Palling David
C/O AMICUS THERAPEUTICS, INC.
6 CEDAR BROOK DRIVE
CRANBURY, NJ 08512		       Senior VP, Drug Development  

Signatures

/s/ Douglas A. Branch, Attorney-in-fact 05/30/2007
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) These shares are held by the David Palling Irrevocable Trust. Mr. Palling disclaims beneficial ownership of the shares held by the David Palling Irrevocable Trust except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of the shares for the purposes of section 16 or for any other purpose.
(2) These options vest and become exercisable in a series of installments. The first installment, which consisted of 25% of the total aggregate number of options granted, vested on July 1, 2005. The remaining options vest and become exercisable in a series of thirty-five successive equal monthly installments of 1,010 shares, beginning on August 1, 2005, with a final installment of 991 shares vesting on July 1, 2008.
(3) These options vest and become exercisable in a series of installments. The first installment, which consisted of 25% of the total aggregate number of options granted, vested on October 20, 2006. The remaining options vest and become exercisable in a series of thirty-five successive equal monthly installments of 626 shares, beginning on November 1, 2006, with a final installment of 590 shares vesting on October 1, 2009.
(4) These options vest and become exercisable in a series of installments. The first installment, which consisted of 25% of the total aggregate number of options granted, vested on January 2, 2007. The remaining options vest and become exercisable in a series of thirty-five successive equal monthly installments of 56 shares, beginning on February 1, 2007 with a final installment of 40 shares vesting on January 1, 2010.
(5) These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, will vest on April 25, 2008. The remaining options vest and become exercisable in a series of thirty-five successive equal monthly installments of 348 shares, beginning on May 1, 2008, with a final installment of 320 shares vesting on April 1, 2011.

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