FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person * Topper James N   2. Issuer Name and Ticker or Trading Symbol AMICUS THERAPEUTICS INC [FOLD] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director __X__ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) C/O FRAZIER HEALTHCARE, 550 HAMILTON AVE., SUITE 100 3. Date of Earliest Transaction (Month/Day/Year) 06/05/2007 (Street) PALO ALTO, CA 94301 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 06/05/2007   C   2,586,886 A (1) 2,586,886 I By Frazier Healthcare IV, L.P. (2) Common Stock 06/05/2007   C   13,128 A (1) 13,128 I By Frazier Affiliates IV, L.P. (2)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Underlying Securities (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Series B Convertible Preferred Stock	(1)	06/05/2007		C			988,446	(1)	(1)	Common Stock	988,446	$ 0	0	I	Frazier Healthcare IV, L.P. (2)
Series B Convertible Preferred Stock	(1)	06/05/2007		C			5,016	(1)	(1)	Common Stock	5,016	$ 0	0	I	Frazier Affiliates IV, L.P. (2)
Series C Convertible Preferred Stock	(1)	06/05/2007		C			1,011,088	(1)	(1)	Common Stock	1,011,088	$ 0	0	I	Frazier Healthcare IV, L.P. (2)
Series C Convertible Preferred Stock	(1)	06/05/2007		C			5,132	(1)	(1)	Common Stock	5,132	$ 0	0	I	Frazier Affiliates IV, L.P. (2)
Series D Convertible Preferred Stock	(1)	06/05/2007		C			572,310	(1)	(1)	Common Stock	572,310	$ 0	0	I	Frazier Healthcare IV, L.P. (2)
Series D Convertible Preferred Stock	(1)	06/05/2007		C			2,904	(1)	(1)	Common Stock	2,904	$ 0	0	I	Frazier Affiliates IV, L.P. (2)
Series B Convertible Preferred Stock Warrant (right to buy)	$ 6.375	06/05/2007		X			15,042	(3)	(3)	Series B Convertible Preferred Stock	15,042	$ 0	0	I	Frazier Healthcare IV, L.P. (2)
Series B Convertible Preferred Stock Warrant (right to buy)	$ 6.375	06/05/2007		X			76	(3)	(3)	Series B Convertible Preferred Stock	76	$ 0	0	I	Frazier Affiliates IV, L.P. (2)
Series B Convertible Preferred Stock	(1)	06/05/2007		J		15,042		(1)	(1)	Common Stock	15,042	$ 0	15,042	I	Frazier Healthcare IV, L.P. (2)
Series B Convertible Preferred Stock	(1)	06/05/2007		J		76		(1)	(1)	Common Stock	76	$ 0	76	I	Frazier Affiliates IV, L.P. (2)
Series B Convertible Preferred Stock	(1)	06/05/2007		C			15,042	(1)	(1)	Common Stock	15,042	$ 0	0	I	Frazier Healthcare IV, L.P. (2)
Series B Convertible Preferred Stock	(1)	06/05/2007		C			76	(1)	(1)	Common Stock	76	$ 0	0	I	Frazier Affiliates IV, L.P. (2)

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Topper James N C/O FRAZIER HEALTHCARE 550 HAMILTON AVE., SUITE 100 PALO ALTO, CA 94301	X	X

Signatures

/s/ James N. Topper		06/07/2007
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Each of the Series B Convertible Preferred Stock, Series C Convertible Preferred Stock and Series D Convertible Preferred Stock automatically converted into common stock on a 1-for-1 basis upon the closing of the Issuer's initial public offering on June 5, 2007.
(2)	The securities are owned directly by the entity listed. The reporting person is a limited partner of FHM IV, LP, the general partner of Frazier Healthcare IV, LP and Frazier Affiliates IV, LP. Voting and investment power over such shares is exercised by FHM IV, LLC in its role as the general partner of FHM IV, LP. The reporting person disclaims beneficial ownership of these shares except to the extent of his proportionate pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of the shares for purposes of Section 16 or for any other purpose.
(3)	The warrants to purchase Series B Convertible Preferred Stock were automatically exercised for cash immediately prior to the closing of the Issuer's initial public offering.

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