Washington, D.C. 20549




Proxy Statement Pursuant to Section 14(a) of
the Securities Exchange Act of 1934 (Amendment No.     )





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Alkermes Important Notice Regarding the Internet Availability of Proxy Materials for the Annual General Meeting of Shareholders to be held on May 22, 2019 at Connaught House, 1 Burlington Road, Dublin 4, Ireland at 12:00 P.M., Irish Standard Time This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. We encourage you to access and review all of the important information contained in the proxy materials before voting. The Notice and Proxy Statement, our Annual Report on Form 10-K for the year ended December 31, 2018 and our Irish Statutory Financial Statements for the year ended December 31, 2018, including related reports, are available at: If you want to receive a paper or e-mail copy of these documents, you must request one. There is no charge to you for requesting a copy. Please make your request for a copy as instructed below on or before May 14, 2019 to facilitate timely delivery. Important information regarding the Internet availability of our proxy materials, instructions for accessing your proxy materials and voting online, and instructions for requesting paper or e-mail copies of your proxy materials are provided on the reverse side of this Notice. SHAREHOLDERS ARE CORDIALLY INVITED TO ATTEND THE ANNUAL GENERAL MEETING AND VOTE IN PERSON. To the Shareholders of Alkermes plc: Notice is hereby given that the Annual General Meeting of Shareholders of Alkermes plc (the “Company”) will be held on May 22, 2019 at Connaught House, 1 Burlington Road, Dublin 4, Ireland at 12:00 P.M., Irish Standard Time for the following purposes: 1. To elect as Class II directors to serve for a three-year term: 01 David W. Anstice AO 02 Robert A. Breyer 03 Wendy L. Dixon, Ph.D. 2. To approve, on an advisory basis, the compensation of the Company’s named executive officers. 3. To ratify, on a non-binding, advisory basis, the appointment of PricewaterhouseCoopers LLP as the independent auditor and accounting firm of the Company, and to authorize, in a binding vote, the Audit and Risk Committee of the Board of Directors of the Company (the “Board”) to set the independent auditor and accounting firm’s remuneration. 4. To approve the Alkermes plc 2018 Stock Option and Incentive Plan, as amended. The Board recommends a vote FOR all director nominees named in Proposal 1 and FOR Proposals 2, 3 and 4. INTERNET TELEPHONE E-MAIL The Securities and Exchange Commission rules permit us to make our proxy materials available to our shareholders via the Internet. Proxy materials for this Annual General Meeting and future meetings may be requested by one of the following methods: To view your proxy materials online, go to Have the 11 digit control number (located below) available when you access the website and follow the instructions. 1-877-777-2857 TOLL FREE If requesting proxy materials by e-mail, please send a blank e-mail with Alkermes plc and your 11 digit control number (located below) in the subject line. No other requests, instructions or other inquiries should be included with your e-mail requesting proxy materials. You must use the 11 digit control number located in the box below. CONTROL NO. SCAN TO VIEW MATERIALS & VOTE w

ALKERMES plc Connaught House 1 Burlington Road Dublin 4, Ireland The following proxy materials are available for you to review at: • Notice & Proxy Statement; • our Annual Report on Form 10-K for the year ended December 31, 2018; and • our Irish Statutory Financial Statements for the year ended December 31, 2018, including related reports. To obtain directions to attend our Annual General Meeting of Shareholders, please contact our Investor Relations department at ACCESSING YOUR PROXY MATERIALS ONLINE Have this notice available when you request a paper copy of the proxy materials or to vote your proxy electronically. You must reference your control number to vote by Internet or request a hard copy. You May Vote Your Proxy When You View The Proxy Materials On The Internet. You Will Be Asked To Follow The Prompts To Vote Your Shares. Your electronic vote authorizes the named proxies to vote your shares in the same manner as if you marked, signed, dated and returned the proxy card. If you wish to appoint as proxy any other person, please contact the Company Secretary. You may vote by Internet or submit your proxy by telephone until 4:59 AM, Irish Standard Time, on May 21, 2019 (11:59 PM, United States Eastern Daylight Time, on May 20, 2019). REQUESTING A PAPER COPY OF THE PROXY MATERIALS By telephone please call 1-877-777-2857 toll free or By logging onto or By e-mail at: Please include Alkermes plc and your control number in the subject line of your e-mail.