UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                    FORM 11-K

                              FOR ANNUAL REPORTS OF
               EMPLOYEE STOCK REPURCHASE SAVINGS AND SIMILAR PLANS
                        PURSUANT TO SECTION 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934


(MARK ONE)


|X|  ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES
     EXCHANGE ACT OF 1934

                   FOR THE FISCAL YEAR ENDED DECEMBER 31, 2006

                                       OR

|_|  TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES
     EXCHANGE ACT OF 1934

FOR THE TRANSITION PERIOD FROM ______________ TO ______________


                        COMMISSION FILE NUMBER 001-09974



                               Enzo Biochem, Inc.
                      Salary Reduction Profit Sharing Plan
 (Full title of the plan and the address of the plan, if different from that of
                            the issuer named below:)


             Enzo Biochem, Inc., 527 Madison Ave. New York, NY 10022
 (Name of issuer of the securities held pursuant to the plan and the address of
                        its principal executive office)

                                       1



                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                                TABLE OF CONTENTS




                                                                    PAGE
                                                             -------------------

Report of Independent Registered Public Accounting Firm              3

FINANCIAL STATEMENTS:

        Statements of Net Assets Available for Benefits
        December 31, 2006 and 2005                                   4

        Statement of Changes in Net Assets Available for
        Benefits For the year ended December 31, 2006                5

        Notes to Financial Statements                                6

SUPPLEMENTAL SCHEDULE AS OF
DECEMBER 31, 2006:

        Schedule H, Item 4i -
        Schedule of Assets Held at End of Year                       10

Signatures                                                           11

Consent of Independent Registered Public Accounting Firm         Exhibit 23

                                       2



             REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM



To the Trustees of
Enzo Biochem, Inc. Salary Reduction Profit Sharing Plan


We have audited the accompanying statements of net assets available for benefits
of Enzo Biochem,  Inc. Salary  Reduction  Profit Sharing Plan (the "Plan") as of
December 31, 2006 and 2005,  and the related  statement of changes in net assets
available  for benefits for the year ended  December 31, 2006.  These  financial
statements are the responsibility of the Plan's  management.  Our responsibility
is to express an opinion on these financial statements based on our audit.

We conducted our audit in accordance with generally  accepted auditing standards
as established by the Auditing Standards Board (United States) and in accordance
with the  standards of the Public  Company  Accounting  Oversight  Board (United
States).  Those  standards  require that we plan and perform the audit to obtain
reasonable assurance about whether the financial statements are free of material
misstatement.  The Plan is not required to have, nor were we engaged to perform,
an audit of its internal  control over financial  reporting.  Our audit included
consideration  of  internal  control  over  financial  reporting  as a basis for
designing audit  procedures that are appropriate in the  circumstances,  but not
for the  purpose of  expressing  an opinion on the  effectiveness  of the Plan's
internal  control  over  financial  reporting.  Accordingly,  we express no such
opinion. An audit also includes examining,  on a test basis, evidence supporting
the  amounts  and  disclosures  in  the  financial  statements,   assessing  the
accounting principles used and significant estimates made by management, as well
as evaluating the overall financial statement presentation.  We believe that our
audit provides a reasonable basis for our opinion.

In our opinion,  the financial  statements  referred to above present fairly, in
all material  respects,  the net assets available for benefits of the Plan as of
December 31, 2006 and 2005, and the changes in net assets available for benefits
for the year ended December 31, 2006 in conformity  with  accounting  principles
generally accepted in the United States of America.

Our audit was  conducted  for the  purpose  of  forming  an opinion on the basic
financial statements taken as a whole. The supplemental  schedule of assets held
for investment  purposes at the end of the year, is presented for the purpose of
additional analysis and is not a required part of the basic financial statements
but is supplementary information required by the Department of Labor's Rules and
Regulations for Reporting and Disclosure  under the Employee  Retirement  Income
Security Act of 1974. The  supplemental  schedule is the  responsibility  of the
Plan's management.  The supplemental schedule has been subjected to the auditing
procedures  applied in the audit of the basic  financial  statements and, in our
opinion,  is fairly  stated in all  material  respects  in relation to the basic
financial statements taken as a whole.


June 26, 2007
Woodbury, New York

                                       3



                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                 STATEMENTS OF NET ASSETS AVAILABLE FOR BENEFITS

                                  DECEMBER 31,


                                                    2006               2005
                                               --------------     --------------

ASSETS

Cash                                           $       54,129     $        6,008
                                               --------------     --------------

Investments at fair value:
  Mutual funds                                      9,583,819          8,315,380
  Common stock                                      2,251,720          1,643,178
  Insurance contract                                1,062,804            783,325
                                               --------------     --------------
                                                   12,898,343         10,741,883
                                               --------------     --------------
Receivables:
  Employer's contributions                            415,536            402,304
  Participants' contributions                          31,404             28,908
                                               --------------     --------------
                                                      446,940            431,212
                                               --------------     --------------

Loans receivable - participants                       175,842            233,700
                                               --------------     --------------

TOTAL ASSETS                                       13,575,254         11,412,803
                                               --------------     --------------

NET ASSETS AVAILABLE FOR BENEFITS              $   13,575,254     $   11,412,803
                                               ==============     ==============


See notes to financial statements.

                                       4



                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

            STATEMENT OF CHANGES IN NET ASSETS AVAILABLE FOR BENEFITS

                      FOR THE YEAR ENDED DECEMBER 31, 2006



Additions to net assets attributed to:
  Participants' contributions                                       $  1,158,334
  Employer's contributions                                               415,536
  Rollover contributions                                                   7,661
  Interest on loans to participants                                       12,641
  Net appreciation in fair value
  of investments:
    Mutual funds                                   $  1,219,063
    Common stock                                        305,392        1,524,455
                                                   ------------     ------------

      Total additions                                                  3,118,627
                                                                    ------------

Deductions from net assets attributed to:
  Benefits paid to participants                                          921,065
  Administrative expenses                                                 35,111
                                                                    ------------

      Total deductions                                                   956,176
                                                                    ------------

Net increase in net assets available for benefits                      2,162,451

Net assets available for benefits, beginning of year                  11,412,803
                                                                    ------------

Net assets available for benefits, end of year                      $ 13,575,254
                                                                    ============


See notes to financial statements.

                                       5



                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                          NOTES TO FINANCIAL STATEMENTS

NOTE 1:     PLAN DESCRIPTION

            The following description of the Enzo Biochem, Inc. Salary Reduction
            Profit Sharing Plan ("the Plan") provides only general  information.
            Participants should refer to the Plan Agreement,  as amended,  for a
            more complete description of the Plan's provisions.

            General
            -------

            The Plan is a defined  contribution plan covering all eligible full-
            time  employees of Enzo Biochem,  Inc.,  the Plan  Sponsor,  and its
            wholly  owned   subsidiaries,   Enzo  Clinical  Labs,   Inc.,   Enzo
            Therapeutics,  Inc. and Enzo Life Sciences, Inc. (collectively,  the
            "Company")  who have  completed  three  months of  service  and have
            attained age twenty-one.

            The Plan is subject to the  provisions  of the  Employee  Retirement
            Income Security Act of 1974 ("ERISA").

            Contributions
            -------------

            Eligible employee  participants can elect to defer up to the maximum
            amount permitted by the Internal Revenue Code for each year ($15,000
            in 2006 and $14,000 in 2005).  Effective  January 1, 2002,  catch-up
            contributions  are also permitted for participants who have attained
            age 50 by December  31st, in accordance  with Section  414(v) of the
            Code, in an amount up to a maximum of $5,000 in 2006,  and $4,000 in
            2005, bringing those participants'  statutory  limitation to $20,000
            for 2006 and $18,000 for 2005.

            In addition, the Company will contribute to the Plan a discretionary
            matching  contribution  equal  to 50% of  the  participant's  401(k)
            contribution,  not to exceed 50% of 10% of the participant's  annual
            compensation.  Participants  who have  completed  a year of  service
            during the plan year and are actively employed as of the last day of
            the plan year  shall be  deemed  eligible  to share in the  matching
            contribution  for the  year.  In 2006 and 2005,  the total  matching
            contributions were $415,536 and $402,304,  respectively, in the form
            of Enzo Biochem Inc. common stock.

            Effective June 1, 2006, the Company amended the Plan's participant's
            salary reduction  election.  The amendment requires  participants to
            make an initial salary deferral election,  or an election to receive
            cash in lieu of a salary  deferral  election,  within 30 days  after
            entering the Plan. A participant's  compensation will  automatically
            be reduced by 3%, which will be considered  to be the  Participant's
            salary reduction election if the Participant does not elect to defer
            a portion of compensation or elect to receive cash in lieu of making
            a salary deferral election.

            Participants' Accounts
            ----------------------

            Contributions  are invested in a choice of mutual  funds,  a benefit
            responsive  investment  contract,  and  the  common  stock  of  Enzo
            Biochem,  Inc.   Contribution   selections  are  designated  by  the
            participants.  Each  participant's  account  is  credited  with  the
            participant's  contribution  and  allocations  of (a) the  Company's
            matching  contribution  and, (b) Plan earnings,  and charged with an
            allocation  of  administrative  expenses.  Allocations  are based on
            participant  compensation  or  account  balances,  as  defined.  The
            benefit to which a  participant  is entitled is the benefit that can
            be provided from the participant's vested account.

            Effective  April 15, 2006,  the Company  amended the Plan to allow a
            Plan  participant  to  elect to  classify  all or part of his or her
            elective deferrals as a Roth 401(k) deferral.

                                       6



                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                          NOTES TO FINANCIAL STATEMENTS


NOTE 1:     PLAN DESCRIPTION (CONTINUED)

            Vesting
            -------

            Participants'  contributed  funds arising from salary reductions and
            the earnings thereon,  are fully vested at all times. Vesting in the
            Company's  matching  contribution and earnings  thereon,  is ratable
            over four years of service.  Any forfeited  amounts shall be applied
            to reduce the Company's  future  contributions.  For the years ended
            December 31, 2006 and 2005, the Company's contributions were reduced
            by forfeitures of approximately $13,700 and $11,200, respectively.

            Loans to Participants
            ---------------------

            Participants  may  borrow  from their  401(k)  accounts a minimum of
            $1,000 up to a maximum  of 50% of their  vested  account  balance or
            $50,000.  Participants are entitled to borrow from their account for
            a maximum  loan term of five years  unless the  proceeds are used to
            acquire a  principal  residence  in which  case it may  exceed  five
            years.  The loans are secured by the  participant's  vested  account
            balance  and  bear a  reasonable  rate of  interest.  Principal  and
            interest is paid ratably through payroll deductions.

            Payment of Benefits
            -------------------

            On  termination  of service due to death,  disability or retirement,
            participants  may elect to receive  an amount  equal to the value of
            the vested  interest in their account in either a lump sum amount or
            in various annuity options.  For termination of service due to other
            reasons,  a participant may receive the value of the vested interest
            in their account as a lump sum distribution. Benefits are payable in
            the form of cash or property.

            Operating Expenses
            ------------------

            Certain  operating  expenses  of the Plan are  absorbed  by the Plan
            Sponsor.


NOTE 2:     SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

            The Plan's  financial  statements  have been  prepared in conformity
            with accounting  principles  generally accepted in the United States
            of America and under the accrual basis method of accounting.

            The Plan's investments are stated at fair value. Investment earnings
            are reinvested in the respective funds.  Investment earnings include
            the Plan's  proportionate  share of realized gains and losses on the
            disposal of  investments,  and  appreciation  or depreciation in the
            fair value of the underlying  investments  comprising the respective
            mutual  funds.  All purchases and sales are recorded on a trade date
            basis.

                                       7



                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                          NOTES TO FINANCIAL STATEMENTS



NOTE 2:     SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)

            The Plan presents in the statement of changes in net asset available
            for benefits, the net appreciation in fair value of its investments,
            which  consists of the realized  gains or losses and the  unrealized
            appreciation (depreciation) on those investments.

            The  preparation  of the financial  statements  in  conformity  with
            accounting  principles  generally  accepted in the United  States of
            America  requires  management to make estimates and assumptions that
            affect reported amounts and disclosures in the financial statements.
            Actual results could differ from those estimates.


NOTE 3:     INVESTMENTS

            The  following  table  presents the fair values,  as  determined  by
            quoted market price, of the investments  except for the Metropolitan
            Life Stable Value  Contract,  which is presented at contract  value,
            which approximates fair value:

                                                             2006        2005
                                                          ----------  ----------

            Enzo Biochem, Inc.*                           $2,251,720  $1,643,178
            American Century Government Bond              $  290,796  $  266,421
            American Funds AMCAP Fund CL A*               $  754,629  $  644,819
            American Funds American Balanced Fund CL A*   $1,327,293  $1,436,346
            American Funds Europacific Growth CL A*       $1,709,274  $1,410,406
            American Funds Washington Mutual
              Investors Fund CL A*                        $2,610,689  $2,299,358
            Baron Growth Fund                             $  148,728  $  112,259
            Calamos Growth Fund CL A                      $  493,974  $  470,628
            Fidelity Contrafund*                          $  974,288  $  823,150
            Fidelity Spartan US Equity Index Fund         $  194,843  $  155,716
            Freemont Bond Fund                            $  163,272  $   75,272
            Hotchkis & Wiley Mid Cap Value CL 1           $  340,975  $  193,168
            Neuberger & Berman Genesis Fund Trust         $  422,533  $  378,051
            Metropolitan Life Stable Value Contract
             (Note 4)*                                    $1,062,804  $  783,325
            Royce Total Return                            $  151,114  $   49,786
            American Funds US Gov't Securities Fund CL A  $    1,411  $       --

            * Denotes investments representing 5% or more of net assets
              available for benefits at December 31, 2006.

                                       8



                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                          NOTES TO FINANCIAL STATEMENTS



NOTE 4:     INVESTMENT CONTRACT WITH INSURANCE COMPANY

            The Plan has a  benefit-responsive  investment contract with MetLife
            Trust Company, National Association (MetLife). MetLife maintains the
            contributions in separate  accounts.  The accounts are credited with
            earnings on the underlying  investments  and charged for participant
            withdrawals and administrative expenses. The contract is included in
            the financial  statements at contract  value as reported to the Plan
            by Counsel Trust Company.  Contract value  represents  contributions
            made under the contract, plus earnings, less participant withdrawals
            and administrative expenses.  Participants may ordinarily direct the
            withdrawal  or transfer of all or a portion of their  investment  at
            contract value.

            There are no reserves  against contract value for credit risk of the
            contract   issuer  or   otherwise   and  contract  is  estimated  to
            approximate  fair value.  The average yield and  crediting  interest
            rates  were   approximately   4.5%  and  4.1%  for  2006  and  2005,
            respectively.

NOTE 5:     RIGHT TO TERMINATE PLAN

            Although it has not  expressed  any intent to do so, the Company has
            the right under the Plan to  discontinue  its  contributions  at any
            time and to terminate the Plan subject to the provisions of ERISA.

NOTE 6:     TAX STATUS

            The Plan obtained its latest  determination  letter in February 2002
            in which the Internal  Revenue  Service  stated that the Plan was in
            compliance with the applicable  requirements of the Internal Revenue
            Code.  The Plan has been amended since  receiving the  determination
            letter.  However,  the plan administrator and the Plan's tax counsel
            believe  that the Plan is currently  designed and being  operated in
            compliance with the applicable  requirements of the Internal Revenue
            Code.

NOTE 7:     PARTY IN INTEREST TRANSACTIONS

            During  2006,  the Plan  purchased  shares of  common  stock in Enzo
            Biochem,  Inc.,  the parent  company of the Plan sponsor,  at market
            prices totaling  approximately  $130,000.  In addition,  shares were
            sold, at market prices totaling approximately  $231,000. At December
            31, 2006 and 2005,  the Plan held Enzo  Biochem,  Inc.  common stock
            with a fair value of $2,251,720 and $1,643,178, respectively.

            Fees  paid  by the  Plan  to the  third  party  Plan  administrators
            amounted to $33,211 for the year ended December 31, 2006.

NOTE 8:     RISKS AND UNCERTAINTIES

            The  Plan  invests  in  various  investment  securities.  Investment
            securities  are  exposed  to  various  risk such as  interest  rate,
            market,  and credit risks.  Due to the level of risk associated with
            certain investment  securities,  it is at least reasonably  possible
            that changes in the values of  investment  securities  will occur in
            the  near  term  and  that  such  changes  could  materially  affect
            participants'  account  balances  and the  amounts  reported  in the
            statement of net assets available for benefits.

                                       9



                               ENZO BIOCHEM, INC.
                              SALARY REDUCTION PLAN

                               SCHEDULE H, ITEM 4I
                     SCHEDULE OF ASSETS HELD AT END OF YEAR

                               E.I.N. # 13-2869332
                                   PLAN # 001

                                DECEMBER 31, 2006



                                                     DESCRIPTION OF
                                                  INVESTMENT INCLUDING
              IDENTITY OF ISSUE,                  MATURITY DATE, RATE
              BORROWER, LESSOR OR               OF INTEREST, COLLATERAL,
                 SIMILAR PARTY                   PAR OR MATURITY VALUE     COST    CURRENT VALUE
(a)                 (b)                                   (c)               (d)         (e)
--- ------------------------------------------  ------------------------   ----    -------------
                                                                        
 *  Enzo Biochem, Inc.                                Common Stock                  $2,251,720
    American Century Government Bond                  Mutual Fund                   $  290,796
    American Funds AMCAP Fund CL A                    Mutual Fund                   $  754,629
    American Funds American Balanced Fund CL A        Mutual Fund                   $1,327,293
    American Funds Europacific Growth CL A            Mutual Fund                   $1,709,274
    American Funds Washington Mutual
      Investors Fund CL A                             Mutual Fund                   $2,610,689
    Baron Growth Fund                                 Mutual Fund                   $  148,728
    Calamos Growth Fund CL A                          Mutual Fund                   $  493,974
    Fidelity Contrafund                               Mutual Fund                   $  974,288
    Fidelity Spartan US Equity Index Fund             Mutual Fund                   $  194,843
    Freemont Bond Fund                                Mutual Fund                   $  163,272
    Hotchkis & Wiley Mid Cap Value CL 1               Mutual Fund                   $  340,975
    Neuberger & Berman Genesis Fund Trust             Mutual Fund                   $  422,533
                                                 Guaranteed Investment
    Metropolitan Life Stable Value Contract             Contract                    $1,062,804
    Royce Total Return                                Mutual Fund                   $  151,114
    American Funds US Gov't Securities Fund CL A      Mutual Fund                   $    1,411
    Participant Loans                                 5.00% - 11.00%       -0-      $  175,842


    * Party-in-interest


See Independent Auditors' Report.

                                       10



                                   SIGNATURES

THE PLAN. Pursuant to the requirements of the Securities Exchange Act of 1934,
the trustees of the below named employee benefit plan has duly caused this
annual report to be signed on its behalf by the undersigned hereunto duly
authorized.

Enzo Biochem, Inc. Salary Reduction Profit Sharing Plan

                                  Date: June 26, 2007

                                  /s/ Herbert Bass
                                  ---------------------
                                  By: Herbert Bass
                                  Trustee


                                       11