UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                    -----------------------------------------

                                 SCHEDULE 13G/A

                    Under the Securities Exchange Act of 1934

                                (Amendment No. 3)

                                   Qiagen N.V.
                    -----------------------------------------
                                (Name of issuer)




                                 Ordinary Shares
                    -----------------------------------------
                        (Title of class of securities)



                                   000N724821
                    -----------------------------------------
                                 (CUSIP number)

                                December 31, 2000
                    -----------------------------------------
             (Date of Event which requires filing of this Statement)

     Check the  appropriate  box to  designate  the rule  pursuant to which this
schedule is filed:

                                ( ) Rule 13d-1(b)
                                (x) Rule 13d-1(c)
                                ( ) Rule 13d-1(d)

--------------------                                           -----------------
CUSIP No. 000N724821                  13G                      Page 2 of 6 Pages
--------------------                                           -----------------



--------------------------------------------------------------------------------
1        NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Deutsche Bank A.G.
--------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                (a) ( )
                                                                         (b) ( )
-------- -----------------------------------------------------------------------
3        SEC USE ONLY

-------- -----------------------------------------------------------------------
4        CITIZENSHIP OR PLACE OF ORGANIZATION

         Federal Republic of Germany
--------------------------------------------------------------------------------
NUMBER OF SHARES             5      SOLE VOTING POWER
BENEFICIALLY OWNED BY
EACH REPORTING                      408,005
PERSON WITH                  ---------------------------------------------------
                             6      SHARED VOTING POWER

                                    8,606,592
                             ---------------------------------------------------
                             7      SOLE DISPOSITIVE POWER

                                    1,166,505
                             ---------------------------------------------------
                             8      SHARED DISPOSITIVE POWER

                                    8,642,892
--------------------------------------------------------------------------------
 9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         9,809,397
--------------------------------------------------------------------------------
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
         CERTAIN SHARES                                                      ( )
--------------------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

         7.1%
--------------------------------------------------------------------------------
12       TYPE OF REPORTING PERSON

         HC, BK, CO
--------------------------------------------------------------------------------


Item 1(a). Name of Issuer:

           Qiagen N.V. (the "Issuer")

Item 1(b). Address of Issuer's Principal Executive Offices:

           The address of the Issuer's  principal  executive office  Sportstraat
50, 5911 KJ Venlo, The Netherlands.

Item 2(a). Name of Person Filing:

           This statement is filed on behalf of Deutsche Bank AG (the "Reporting
Person"). This Schedule 13G/A is being filed pursuant to Rule 13d-2(b).

Item 2(b). Address of Principal Business Office or, if none, Residence:

           The  principal   place  of  business  of  the  Reporting   Person  is
Taunusanlage 12, D-60325, Frankfurt am Main, Federal Republic of Germany.

Item 2(c). Citizenship:

           The  citizenship  of the  Reporting  Person is set forth on the cover
page.

Item 2(d). Title of Class of Securities:

           The  title  of the  securities  is  ordinary  shares  (the  "Ordinary
Shares").

Item 2(e).  CUSIP Number:

           The  CUSIP  number  of  the  Ordinary  Shares  is  set  forth  on the
applicable cover page.

Item 3.    If this statement is filed pursuant to Rules 13d-1(b), or 13d-2(b) or
           (c), check whether the person filing is a:

           (a) ( )    Broker or dealer registered under section 15 of the Act;

           (b) ( )    Bank as defined in section 3(a)(6) of the Act;

           (c) ( )    Insurance  Company as defined in section  3(a)(19)  of the
                      Act;

           (d) ( )    Investment  Company  registered  under  section  8 of  the
                      Investment Company Act of 1940;

           (e) ( )    An  investment  adviser  in  accordance  with  Rule  13d-1
                      (b)(1)(ii)(E);

           (f) ( )    An employee  benefit plan, or endowment fund in accordance
                      with Rule 13d-1 (b)(1)(ii)(F);

           (g) ( )    A parent  holding  company or control person in accordance
                      with Rule 13d-1 (b)(1)(ii)(G);

           (h) ( )    A savings  association  as defined in section  3(b) of the
                      Federal Deposit Insurance Act;

           (i) ( )    A church plan that is excluded  from the  definition of an
                      investment   company   under   section   3(c)(14)  of  the
                      Investment Company Act of 1940;

           (j) ( )    Group, in accordance with Rule 13d-1 (b)(1)(ii)(J).

           If this  statement  is filed  pursuant to Rule 13d-1 (c),  check this
box. (x)

Item 4.    Ownership.

           (a)        Amount beneficially owned:

                      The  Reporting  Person  owns the  amount  of the  Ordinary
           Shares set forth on the cover page.

           (b)        Percent of class:

                      The Reporting  Person owns the  percentage of the Ordinary
           Shares set forth on the cover page.

           (c)        Number of shares as to which such person has:

                      (i)        sole power to vote or to direct the vote:

                                 The Reporting Person has the sole power to vote
                      or direct the vote of the Ordinary Shares set forth on the
                      cover page.

                      (ii)       shared power to vote or to direct the vote:

                                 The  Reporting  Person has the shared  power to
                      vote or direct the vote of the  Ordinary  Shares set forth
                      on the cover page.

                      (iii)      sole   power  to   dispose  or  to  direct  the
                                 disposition of:

                                 The  Reporting  Person  has the  sole  power to
                      dispose or direct the  disposition of the Ordinary  Shares
                      set forth on the cover page.

                      (iv)       shared  power  to  dispose  or  to  direct  the
                                 disposition of:

                                 The  Reporting  Person has the shared  power to
                      dispose or direct the  disposition of the Ordinary  Shares
                      set forth on the cover page.

Item 5.    Ownership of Five Percent or Less of a Class.

           Not applicable.

Item 6.    Ownership of More than Five Percent on Behalf of Another Person.

           Investment  management  clients of the subsidiaries  listed in item 7
below have the ultimate  right to any  dividends  from  Ordinary  Shares and the
proceeds from the sale of Ordinary Shares.

Item 7.    Identification  and  Classification  of the Subsidiary Which Acquired
           the Security Being Reported on by the Parent Holding Company.

           The following are subsidiaries of the Reporting Person which acquired
Ordinary  Shares  included in the figures on the cover pages:  Ethemea GmbH, DWS
Investment  GmbH,  Deutsche  Vermogensbildungsgesellschaft  mbH,  DWS  (Austria)
Investment Gesellschaft mbH, DWS Investment Management S.A. Luxemburg,  Deutsche
Asset Management Limited, Deutsche Asset Management  Investmentgesellschaft mbH,
Deutsche Asset Management International GmbH, Versicherungsholding der Deutschen
Bank AG, Deutscher Herold  Lebensversicherungs-AG der Deutschen Bank, DB Gestion
Sociedad  Gestora de  Instituciones de Inversion  Colectiva,  Sociedad  Anonima,
Deutsche  Bank  International  Ltd.,  Deutsche  Securities  Ltd.,  Deutsche Bank
Luxembourg S.A., Deutsche Asset Management SA, Paris,  Deutsche Asset Management
SGR SpA and Deutsche Funds Management Ltd.

Item 8.    Identification and Classification of Members of the Group.

           Not applicable.

Item 9.    Notice of Dissolution of Group.

           Not applicable.

Item 10.   Certification.

           By signing  below I certify  that,  to the best of my  knowledge  and
belief, the securities  referred to above were not acquired and are not held for
the purpose of or with the effect of changing or influencing  the control of the
issuer of the  securities  and were not acquired and are not held in  connection
with or as a participant in any transaction having that purpose or effect.


                                    SIGNATURE

     After  reasonable  inquiry and to the best of my  knowledge  and belief,  I
certify that the information  set forth in this statement is true,  complete and
correct.

Dated:  February 8, 2001

                                                DEUTSCHE BANK AG

                                                By: /s/ Christoph Kirschhofer
                                                   -----------------------------
                                                   Name:   Christoph Kirschhofer
                                                   Title:  Director

                                                By: /s/ Karl-Heinz Baumann
                                                   -----------------------------
                                                   Name:   Karl-Heinz Baumann
                                                   Title:  Director