Mixed close after rate increase

The markets closed mixed with the Dow gaining 46 points to 21,374 while Nasdaq fell 25 points to 6,194 after the Federal Reserve raised interest rates by a quarter percentage point.


On the upside


Epizyme (Nasdaq: EPZM) reported upbeat interim data from a Phase 2 clinical trial of tazemetostat


Shares of Athenex (Nasdaq: ATNX) climbed in its market debut.


Shares of Omeros (Nasdaq: OMER) extended its gains.


On the downside


Retreating crude oil prices weighed down shares of Halcon Resources (NYSE: HK), Oasis Petroleum (NYSE: OAS), SM Energy (NYSE: SM).


Shares of oilfield services firm Weatherford International (NYSE: WFT) fell alongside oil companies.

Synchronoss Technologies (Nasdaq: SNCR) must restate financial reports from 2015 and 2016.


In the broad market, declining issues edged out advancers by a margin of 9 to 8 on the NYSE and by nearly 3 to 2 on Nasdaq. The broader S&P 500 slipped 2 points to 2,437. Bitcoin plummeted $159 to $2528.


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