Ownership Submission
FORM 3
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Burke Steven Keith
2. Date of Event Requiring Statement (Month/Day/Year)
10/21/2014
3. Issuer Name and Ticker or Trading Symbol
PROTEON THERAPEUTICS INC [PRTO]
(Last)
(First)
(Middle)
C/O PROTEON THERAPEUTICS, 200 WEST STREET
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Sr. VP & Chief Medical Officer
5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

WALTHAM, MA 02451
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(Month/Day/Year)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (Right to Buy)   (1) 08/01/2016 Common Stock 30,411 (4) $ 1.905 (4) D  
Stock Option (Right to Buy)   (1) 09/10/2017 Common Stock 12,287 (4) $ 2.381 (4) D  
Stock Option (Right to Buy)   (1) 06/19/2019 Common Stock 14,898 (4) $ 3.174 (4) D  
Stock Option (Right to Buy)   (2) 10/26/2021 Common Stock 57,934 (4) $ 1.27 (4) D  
Stock Option (Right to Buy)   (3) 06/23/2024 Common Stock 71,218 (4) $ 4.92 (4) D  
Stock Option (Right to Buy)   (3) 06/23/2024 Common Stock 10,696 (4) $ 4.92 (4) D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Burke Steven Keith
C/O PROTEON THERAPEUTICS
200 WEST STREET
WALTHAM, MA 02451
      Sr. VP & Chief Medical Officer  

Signatures

/s/ Steven K. Burke 10/21/2014
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The shares underlying these options are fully vested.
(2) This option is fully exercisable prior to its vesting, subject to a repurchase right held by the Issuer on the shares underlying this option that lapses (based on the original option vesting schedule) in equal quarterly installments over four years.
(3) This option is fully exercisable prior to its vesting, subject to a repurchase right held by the Issuer on the shares underlying this option that lapses (based on the original option vesting schedule) 25% on the first anniversary of the grant date and the remaining shares in equal quarterly installments over the next three years.
(4) Reflects a 1-for-15.87 reverse stock split effected on October 6, 2014.
 
Remarks:
Exhibit 24.1 Power of Attorney

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